Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism

European Journal of Pharmacology

Volumn 666, Issue 1-3, 2011, Pages 165-172

  Pei, Yingzi ^a,b   Ma, Ping ^b,d   Wang, Xin ^a,b   Zhang, Wei ^a,b   Zhang, Xia ^b,c   Zheng, Ping ^b,c   Yan, Lin ^b,c   Xu, Qingbin ^d   Dai, Guidong ^b,c  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine   (China)

^c Ningxia Research Institute of Medicine and Pharmacy   (China)

^d AFFILIATED HOSPITAL OF NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

ADMA DDAH2; Akt eNOS; Monocrotaline; Pulmonary hypertension; Rosuvastatin

Indexed keywords

DIMETHYLARGININASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROLASE; METHYLTRANSFERASE; MONOCROTALINE; N(G),N(G) DIMETHYLARGININE; PROTEIN ARGININE METHYLTRANSFERASE 1; PROTEIN KINASE B; ROSUVASTATIN; UNCLASSIFIED DRUG;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKENING; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE HYPERTROPHY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION;

AMIDOHYDROLASES; ANIMALS; ARGININE; BIOLOGICAL MARKERS; BODY WEIGHT; FLUOROBENZENES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; HEART; HYPERTENSION, PULMONARY; LUNG; MALE; MONOCROTALINE; NITRIC OXIDE SYNTHASE TYPE III; ORGAN SIZE; PROTEIN-ARGININE N-METHYLTRANSFERASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SULFONAMIDES; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 79960030509     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.05.035     Document Type: Article

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