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Volumn 18, Issue 8, 2016, Pages 1172-1183

Influence of Sae-regulated and Agr-regulated factors on the escape of Staphylococcus aureus from human macrophages

Author keywords

escape; intracellular; leucocidin; LukAB; phagocytes; phenol soluble modulins; PSM 1 4; Staphylococcus aureus

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; CRYOPYRIN; INFLAMMASOME; BACTERIAL PROTEIN; CASPASE; LEUKOCIDIN; LEUKOCIDIN AB, STAPHYLOCOCCUS AUREUS;

EID: 84961282143     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12577     Document Type: Article
Times cited : (61)

References (46)
  • 1
    • 0034332193 scopus 로고    scopus 로고
    • The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations
    • Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., et al. (2000) The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96: 3086–3093.
    • (2000) Blood , vol.96 , pp. 3086-3093
    • Agerberth, B.1    Charo, J.2    Werr, J.3    Olsson, B.4    Idali, F.5    Lindbom, L.6
  • 2
    • 84901058157 scopus 로고    scopus 로고
    • The bicomponent pore-forming leucocidins of Staphylococcus aureus
    • Alonzo, F., 3rd, and Torres, V.J. (2014) The bicomponent pore-forming leucocidins of Staphylococcus aureus. Microbiol Mol Biol Rev 78: 199–230.
    • (2014) Microbiol Mol Biol Rev , vol.78 , pp. 199-230
    • Alonzo, F.1    Torres, V.J.2
  • 3
    • 29144482705 scopus 로고    scopus 로고
    • Allelic replacement in Staphylococcus aureus with inducible counter-selection
    • Bae, T., and Schneewind, O. (2006) Allelic replacement in Staphylococcus aureus with inducible counter-selection. Plasmid 55: 58–63.
    • (2006) Plasmid , vol.55 , pp. 58-63
    • Bae, T.1    Schneewind, O.2
  • 4
    • 84901654481 scopus 로고    scopus 로고
    • A nasal epithelial receptor for Staphylococcus aureus WTA governs adhesion to epithelial cells and modulates nasal colonization
    • Baur, S., Rautenberg, M., Faulstich, M., Grau, T., Severin, Y., Unger, C., et al. (2014) A nasal epithelial receptor for Staphylococcus aureus WTA governs adhesion to epithelial cells and modulates nasal colonization. PLoS Pathog 10: e1004089.
    • (2014) PLoS Pathog , vol.10
    • Baur, S.1    Rautenberg, M.2    Faulstich, M.3    Grau, T.4    Severin, Y.5    Unger, C.6
  • 5
    • 84904759616 scopus 로고    scopus 로고
    • The psmalpha locus regulates production of Staphylococcus aureus alpha-toxin during infection
    • Berube, B.J., Sampedro, G.R., Otto, M., and Bubeck Wardenburg, J. (2014) The psmalpha locus regulates production of Staphylococcus aureus alpha-toxin during infection. Infect Immun 82: 3350–3358.
    • (2014) Infect Immun , vol.82 , pp. 3350-3358
    • Berube, B.J.1    Sampedro, G.R.2    Otto, M.3    Bubeck Wardenburg, J.4
  • 6
    • 34249881878 scopus 로고    scopus 로고
    • Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism
    • Boisset, S., Geissmann, T., Huntzinger, E., Fechter, P., Bendridi, N., Possedko, M., et al. (2007) Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. Genes Dev 21: 1353–1366.
    • (2007) Genes Dev , vol.21 , pp. 1353-1366
    • Boisset, S.1    Geissmann, T.2    Huntzinger, E.3    Fechter, P.4    Bendridi, N.5    Possedko, M.6
  • 7
    • 84864004481 scopus 로고    scopus 로고
    • Organizational requirements of the SaeR binding sites for a functional P1 promoter of the sae operon in Staphylococcus aureus
    • Cho, H., Jeong, D.W., Li, C., and Bae, T. (2012) Organizational requirements of the SaeR binding sites for a functional P1 promoter of the sae operon in Staphylococcus aureus. J Bacteriol 194: 2865–2876.
    • (2012) J Bacteriol , vol.194 , pp. 2865-2876
    • Cho, H.1    Jeong, D.W.2    Li, C.3    Bae, T.4
  • 8
    • 84919485199 scopus 로고    scopus 로고
    • The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts
    • Cole, J., Aberdein, J., Jubrail, J., and Dockrell, D.H. (2014) The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts. Adv Microb Physiol 65: 125–202.
    • (2014) Adv Microb Physiol , vol.65 , pp. 125-202
    • Cole, J.1    Aberdein, J.2    Jubrail, J.3    Dockrell, D.H.4
  • 10
    • 84879518407 scopus 로고    scopus 로고
    • Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1
    • DuMont, A.L., Yoong, P., Day, C.J., Alonzo, F., 3rd, McDonald, W.H., Jennings, M.P., and Torres, V.J. (2013a) Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1. Proc Natl Acad Sci U S A 110: 10794–10799.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 10794-10799
    • DuMont, A.L.1    Yoong, P.2    Day, C.J.3    Alonzo, F.4    McDonald, W.H.5    Jennings, M.P.6    Torres, V.J.7
  • 12
    • 84894266542 scopus 로고    scopus 로고
    • Identification of a crucial residue required for Staphylococcus aureus LukAB cytotoxicity and receptor recognition
    • DuMont, A.L., Yoong, P., Liu, X., Day, C.J., Chumbler, N.M., James, D.B., et al. (2014) Identification of a crucial residue required for Staphylococcus aureus LukAB cytotoxicity and receptor recognition. Infect Immun 82: 1268–1276.
    • (2014) Infect Immun , vol.82 , pp. 1268-1276
    • DuMont, A.L.1    Yoong, P.2    Liu, X.3    Day, C.J.4    Chumbler, N.M.5    James, D.B.6
  • 13
    • 84961216185 scopus 로고    scopus 로고
    • Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination
    • Flannagan, R.S., Heit, B., and Heinrichs, D.E. (2015) Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination. Cell Microbiol. doi:http://dx.doi.org/10.1111/cmi.12527
    • (2015) Cell Microbiol
    • Flannagan, R.S.1    Heit, B.2    Heinrichs, D.E.3
  • 14
    • 84871957949 scopus 로고    scopus 로고
    • Intracellular Staphylococcus aureus: live-in and let die
    • Fraunholz, M., and Sinha, B. (2012) Intracellular Staphylococcus aureus: live-in and let die. Front Cell Infect Microbiol 2: 43.
    • (2012) Front Cell Infect Microbiol , vol.2 , pp. 43
    • Fraunholz, M.1    Sinha, B.2
  • 15
    • 47049090160 scopus 로고    scopus 로고
    • The virulence regulator Sae of Staphylococcus aureus: promoter activities and response to phagocytosis-related signals
    • Geiger, T., Goerke, C., Mainiero, M., Kraus, D., and Wolz, C. (2008) The virulence regulator Sae of Staphylococcus aureus: promoter activities and response to phagocytosis-related signals. J Bacteriol 190: 3419–3428.
    • (2008) J Bacteriol , vol.190 , pp. 3419-3428
    • Geiger, T.1    Goerke, C.2    Mainiero, M.3    Kraus, D.4    Wolz, C.5
  • 16
    • 84870837168 scopus 로고    scopus 로고
    • The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression
    • Geiger, T., Francois, P., Liebeke, M., Fraunholz, M., Goerke, C., Krismer, B., et al. (2012) The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression. PLoS Pathog 8: e1003016.
    • (2012) PLoS Pathog , vol.8
    • Geiger, T.1    Francois, P.2    Liebeke, M.3    Fraunholz, M.4    Goerke, C.5    Krismer, B.6
  • 17
    • 78651427582 scopus 로고    scopus 로고
    • Expression of delta-toxin by Staphylococcus aureus mediates escape from phago-endosomes of human epithelial and endothelial cells in the presence of beta-toxin
    • Giese, B., Glowinski, F., Paprotka, K., Dittmann, S., Steiner, T., Sinha, B., and Fraunholz, M.J. (2011) Expression of delta-toxin by Staphylococcus aureus mediates escape from phago-endosomes of human epithelial and endothelial cells in the presence of beta-toxin. Cell Microbiol 13: 316–329.
    • (2011) Cell Microbiol , vol.13 , pp. 316-329
    • Giese, B.1    Glowinski, F.2    Paprotka, K.3    Dittmann, S.4    Steiner, T.5    Sinha, B.6    Fraunholz, M.J.7
  • 19
    • 84896391432 scopus 로고    scopus 로고
    • Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin alpha
    • Grosz, M., Kolter, J., Paprotka, K., Winkler, A.C., Schafer, D., Chatterjee, S.S., et al. (2013) Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin alpha. Cell Microbiol. DOI: http://dx.doi.org/10.1111/cmi.12233.
    • (2013) Cell Microbiol
    • Grosz, M.1    Kolter, J.2    Paprotka, K.3    Winkler, A.C.4    Schafer, D.5    Chatterjee, S.S.6
  • 20
    • 0019997730 scopus 로고
    • Mac-1 antigen: quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen
    • Ho, M.K., and Springer, T.A. (1982) Mac-1 antigen: quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen. J Immunol 128: 2281–2286.
    • (1982) J Immunol , vol.128 , pp. 2281-2286
    • Ho, M.K.1    Springer, T.A.2
  • 21
    • 84868314254 scopus 로고    scopus 로고
    • Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome
    • Holzinger, D., Gieldon, L., Mysore, V., Nippe, N., Taxman, D.J., Duncan, J.A., et al. (2012) Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome. J Leukoc Biol 92: 1069–1081.
    • (2012) J Leukoc Biol , vol.92 , pp. 1069-1081
    • Holzinger, D.1    Gieldon, L.2    Mysore, V.3    Nippe, N.4    Taxman, D.J.5    Duncan, J.A.6
  • 22
    • 84940920011 scopus 로고    scopus 로고
    • Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages
    • Jubrail, J., Morris, P., Bewley, M.A., Stoneham, S., Johnston, S.A., Foster, S.J., et al. (2016) Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages. Cell Microbiol 18(1): 80–96.
    • (2016) Cell Microbiol , vol.18 , Issue.1 , pp. 80-96
    • Jubrail, J.1    Morris, P.2    Bewley, M.A.3    Stoneham, S.4    Johnston, S.A.5    Foster, S.J.6
  • 23
    • 84929494277 scopus 로고    scopus 로고
    • Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage
    • Kitur, K., Parker, D., Nieto, P., Ahn, D.S., Cohen, T.S., Chung, S., et al. (2015) Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage. PLoS Pathog 11: e1004820.
    • (2015) PLoS Pathog , vol.11
    • Kitur, K.1    Parker, D.2    Nieto, P.3    Ahn, D.S.4    Cohen, T.S.5    Chung, S.6
  • 24
    • 84861186812 scopus 로고    scopus 로고
    • Soluble CD163 promotes recognition, phagocytosis and killing of Staphylococcus aureus via binding of specific fibronectin peptides
    • Kneidl, J., Loffler, B., Erat, M.C., Kalinka, J., Peters, G., Roth, J., and Barczyk, K. (2012) Soluble CD163 promotes recognition, phagocytosis and killing of Staphylococcus aureus via binding of specific fibronectin peptides. Cell Microbiol 14: 914–936.
    • (2012) Cell Microbiol , vol.14 , pp. 914-936
    • Kneidl, J.1    Loffler, B.2    Erat, M.C.3    Kalinka, J.4    Peters, G.5    Roth, J.6    Barczyk, K.7
  • 25
    • 65349084974 scopus 로고    scopus 로고
    • Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors
    • Koziel, J., Maciag-Gudowska, A., Mikolajczyk, T., Bzowska, M., Sturdevant, D.E., Whitney, A.R., et al. (2009) Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors. PLoS One 4: e5210.
    • (2009) PLoS One , vol.4
    • Koziel, J.1    Maciag-Gudowska, A.2    Mikolajczyk, T.3    Bzowska, M.4    Sturdevant, D.E.5    Whitney, A.R.6
  • 26
    • 39049169762 scopus 로고    scopus 로고
    • A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages
    • Kubica, M., Guzik, K., Koziel, J., Zarebski, M., Richter, W., Gajkowska, B., et al. (2008) A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages. PLoS One 3: e1409.
    • (2008) PLoS One , vol.3
    • Kubica, M.1    Guzik, K.2    Koziel, J.3    Zarebski, M.4    Richter, W.5    Gajkowska, B.6
  • 27
    • 84947751820 scopus 로고    scopus 로고
    • Novel antibody–antibiotic conjugate eliminates intracellular S. aureus
    • Lehar, S.M., Pillow, T., Xu, M., Staben, L., Kajihara, K.K., Vandlen, R., et al. (2015) Novel antibody–antibiotic conjugate eliminates intracellular S. aureus. Nature 527: 323–328.
    • (2015) Nature , vol.527 , pp. 323-328
    • Lehar, S.M.1    Pillow, T.2    Xu, M.3    Staben, L.4    Kajihara, K.K.5    Vandlen, R.6
  • 28
    • 77649223154 scopus 로고    scopus 로고
    • Staphylococcus aureus Panton-Valentine leukocidin is a very potent cytotoxic factor for human neutrophils
    • Loffler, B., Hussain, M., Grundmeier, M., Bruck, M., Holzinger, D., Varga, G., et al. (2010) Staphylococcus aureus Panton-Valentine leukocidin is a very potent cytotoxic factor for human neutrophils. PLoS Pathog 6: e1000715.
    • (2010) PLoS Pathog , vol.6
    • Loffler, B.1    Hussain, M.2    Grundmeier, M.3    Bruck, M.4    Holzinger, D.5    Varga, G.6
  • 29
    • 0032551901 scopus 로고    scopus 로고
    • Staphylococcus aureus infections
    • Lowy, F.D. (1998) Staphylococcus aureus infections. N Engl J Med 339: 520–532.
    • (1998) N Engl J Med , vol.339 , pp. 520-532
    • Lowy, F.D.1
  • 30
    • 84936769144 scopus 로고    scopus 로고
    • Staphylococcus aureus leukocidin A/B (LukAB) kills human monocytes via host NLRP3 and ASC when extracellular, but not intracellular
    • Melehani, J.H., James, D.B., DuMont, A.L., Torres, V.J., and Duncan, J.A. (2015) Staphylococcus aureus leukocidin A/B (LukAB) kills human monocytes via host NLRP3 and ASC when extracellular, but not intracellular. PLoS Pathog 11: e1004970.
    • (2015) PLoS Pathog , vol.11
    • Melehani, J.H.1    James, D.B.2    DuMont, A.L.3    Torres, V.J.4    Duncan, J.A.5
  • 31
    • 84870772944 scopus 로고    scopus 로고
    • CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism
    • Nuxoll, A.S., Halouska, S.M., Sadykov, M.R., Hanke, M.L., Bayles, K.W., Kielian, T., et al. (2012) CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism. PLoS Pathog 8: e1003033.
    • (2012) PLoS Pathog , vol.8
    • Nuxoll, A.S.1    Halouska, S.M.2    Sadykov, M.R.3    Hanke, M.L.4    Bayles, K.W.5    Kielian, T.6
  • 32
    • 75649132285 scopus 로고    scopus 로고
    • SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis
    • Nygaard, T.K., Pallister, K.B., Ruzevich, P., Griffith, S., Vuong, C., and Voyich, J.M. (2010) SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis 201: 241–254.
    • (2010) J Infect Dis , vol.201 , pp. 241-254
    • Nygaard, T.K.1    Pallister, K.B.2    Ruzevich, P.3    Griffith, S.4    Vuong, C.5    Voyich, J.M.6
  • 33
    • 84866337917 scopus 로고    scopus 로고
    • MRSA virulence and spread
    • Otto, M. (2012) MRSA virulence and spread. Cell Microbiol 14: 1513–1521.
    • (2012) Cell Microbiol , vol.14 , pp. 1513-1521
    • Otto, M.1
  • 34
    • 84884279163 scopus 로고    scopus 로고
    • Phenol-soluble modulins and staphylococcal infection
    • Peschel, A., and Otto, M. (2013) Phenol-soluble modulins and staphylococcal infection. Nat Rev Microbiol 11: 667–673.
    • (2013) Nat Rev Microbiol , vol.11 , pp. 667-673
    • Peschel, A.1    Otto, M.2
  • 35
    • 53349128304 scopus 로고    scopus 로고
    • RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus
    • Queck, S.Y., Jameson-Lee, M., Villaruz, A.E., Bach, T.H., Khan, B.A., Sturdevant, D.E., et al. (2008) RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell 32: 150–158.
    • (2008) Mol Cell , vol.32 , pp. 150-158
    • Queck, S.Y.1    Jameson-Lee, M.2    Villaruz, A.E.3    Bach, T.H.4    Khan, B.A.5    Sturdevant, D.E.6
  • 36
    • 84859872348 scopus 로고    scopus 로고
    • Neutrophils in innate host defense against Staphylococcus aureus infections
    • Rigby, K.M., and DeLeo, F.R. (2012) Neutrophils in innate host defense against Staphylococcus aureus infections. Semin Immunopathol 34: 237–259.
    • (2012) Semin Immunopathol , vol.34 , pp. 237-259
    • Rigby, K.M.1    DeLeo, F.R.2
  • 37
    • 0043066898 scopus 로고    scopus 로고
    • Biphasic intracellular expression of Staphylococcus aureus virulence factors and evidence for Agr-mediated diffusion sensing
    • Shompole, S., Henon, K.T., Liou, L.E., Dziewanowska, K., Bohach, G.A., and Bayles, K.W. (2003) Biphasic intracellular expression of Staphylococcus aureus virulence factors and evidence for Agr-mediated diffusion sensing. Mol Microbiol 49: 919–927.
    • (2003) Mol Microbiol , vol.49 , pp. 919-927
    • Shompole, S.1    Henon, K.T.2    Liou, L.E.3    Dziewanowska, K.4    Bohach, G.A.5    Bayles, K.W.6
  • 38
  • 39
    • 84880329115 scopus 로고    scopus 로고
    • Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis
    • Surewaard, B.G., de Haas, C.J., Vervoort, F., Rigby, K.M., DeLeo, F.R., Otto, M., et al. (2013) Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis. Cell Microbiol 15: 1427–1437.
    • (2013) Cell Microbiol , vol.15 , pp. 1427-1437
    • Surewaard, B.G.1    de Haas, C.J.2    Vervoort, F.3    Rigby, K.M.4    DeLeo, F.R.5    Otto, M.6
  • 40
    • 84957660192 scopus 로고    scopus 로고
    • Staphylococcus aureus strain USA300 perturbs acquisition of lysosomal enzymes and requires phagosomal acidification for survival inside macrophages
    • Tranchemontagne, Z.R., Camire, R.B., O'Donnell, V.J., Baugh, J., and Burkholder, K.M. (2015) Staphylococcus aureus strain USA300 perturbs acquisition of lysosomal enzymes and requires phagosomal acidification for survival inside macrophages. Infect Immun 84: 241–253.
    • (2015) Infect Immun , vol.84 , pp. 241-253
    • Tranchemontagne, Z.R.1    Camire, R.B.2    O'Donnell, V.J.3    Baugh, J.4    Burkholder, K.M.5
  • 41
    • 84918571423 scopus 로고    scopus 로고
    • Neutrophil-mediated phagocytosis of Staphylococcus aureus
    • van Kessel, K.P., Bestebroer, J., and van Strijp, J.A. (2014) Neutrophil-mediated phagocytosis of Staphylococcus aureus. Front Immunol 5: 467.
    • (2014) Front Immunol , vol.5 , pp. 467
    • van Kessel, K.P.1    Bestebroer, J.2    van Strijp, J.A.3
  • 43
    • 24744461675 scopus 로고    scopus 로고
    • Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils
    • Voyich, J.M., Braughton, K.R., Sturdevant, D.E., Whitney, A.R., Said-Salim, B., Porcella, S.F., et al. (2005) Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol 175: 3907–3919.
    • (2005) J Immunol , vol.175 , pp. 3907-3919
    • Voyich, J.M.1    Braughton, K.R.2    Sturdevant, D.E.3    Whitney, A.R.4    Said-Salim, B.5    Porcella, S.F.6
  • 44
    • 84860593366 scopus 로고    scopus 로고
    • Staphylococcus aureus determinants for nasal colonization
    • Weidenmaier, C., Goerke, C., and Wolz, C. (2012) Staphylococcus aureus determinants for nasal colonization. Trends Microbiol 20: 243–250.
    • (2012) Trends Microbiol , vol.20 , pp. 243-250
    • Weidenmaier, C.1    Goerke, C.2    Wolz, C.3
  • 45
    • 70450239468 scopus 로고    scopus 로고
    • Transcription of the phage-encoded Panton-Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background
    • Wirtz, C., Witte, W., Wolz, C., and Goerke, C. (2009) Transcription of the phage-encoded Panton-Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background. Microbiology 155: 3491–3499.
    • (2009) Microbiology , vol.155 , pp. 3491-3499
    • Wirtz, C.1    Witte, W.2    Wolz, C.3    Goerke, C.4


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