Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly

International Journal of Antimicrobial Agents

Volumn 47, Issue 4, 2016, Pages 289-296

  Khachatoorian, Ronik ^a   Riahi, Rana ^a   Ganapathy, Ekambaram ^a   Shao, Hao ^b   Wheatley, Nicole M ^c   Sundberg, Christopher ^a   Jung, Chun Ling ^a   Ruchala, Piotr ^a   Dasgupta, Asim ^a   Arumugaswami, Vaithilingaraja ^a,d   Gestwicki, Jason E ^b   French, Samuel W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Allosteric heat shock protein inhibitors; Hepatitis C virus; Hsc70; Hsp70; Viral assembly; Viral translation

Indexed keywords

ANTIVIRUS AGENT; HCV4 PEPTIDE; JG 258; JG 40; JG 98; MAL 3 101; PEPTIDE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VER 155008; VIRUS PROTEIN; YM 01; ENZYME INHIBITOR; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG TOLERABILITY; HEPATITIS C VIRUS; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; IC50; LIFE CYCLE; NONHUMAN; PRIORITY JOURNAL; VIRION; VIRUS ASSEMBLY; VIRUS ENTRY; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; HEPACIVIRUS; LIVER CELL; METABOLISM; PHYSIOLOGY; VIROLOGY;

ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; ENZYME INHIBITORS; HEPACIVIRUS; HEPATOCYTES; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; VIRUS ASSEMBLY;

EID: 84961266484     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2016.01.012     Document Type: Article

References (29)

1. C.W. Shepard, L. Finelli, and M.J. Alter Global epidemiology of hepatitis C virus infection Lancet Infect Dis 5 2005 558 567
2. H.B. El-Serag Hepatocellular carcinoma: an epidemiologic view J Clin Gastroenterol 35 5 Suppl. 2 2002 S72 S78
3. E.F. Donaldson, P.R. Harrington, J.J. O'Rear, and L.K. Naeger Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir Hepatology 61 2015 56 65
4. M.L. Shiffman What future for ribavirin Liver Int 29 Suppl. 1 2009 68 73
5. C. Hedskog, B. Doehle, K. Chodavarapu, V. Gontcharova, J. Crespo Garcia, R. De Knegt, and et al. Characterization of hepatitis C virus intergenotypic recombinant strains and associated virological response to sofosbuvir/ribavirin Hepatology 61 2015 471 480
6. B.D. Lindenbach, and C.M. Rice Unravelling hepatitis C virus replication from genome to function Nature 436 2005 933 938
7. D. Ross-Thriepland, and M. Harris Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on! J Gen Virol 96 2015 727 738
8. M.P. Mayer, and B. Bukau Hsp70 chaperones: cellular functions and molecular mechanism Cell Mol Life Sci 62 2005 670 684
9. Y. Xing, T. Bocking, M. Wolf, N. Grigorieff, T. Kirchhausen, and S.C. Harrison Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly EMBO J 29 2010 655 665
10. J. Yochem, H. Uchida, M. Sunshine, H. Saito, C.P. Georgopoulos, and M. Feiss Genetic analysis of two genes, dnaJ and dnaK, necessary for Escherichia coli and bacteriophage lambda DNA replication Mol Gen Genet 164 1978 9 14
11. O. Gonzalez, V. Fontanes, S. Raychaudhuri, R. Loo, J. Loo, V. Arumugaswami, and et al. The heat shock protein inhibitor quercetin attenuates hepatitis C virus production Hepatology 50 2009 1756 1764
12. R. Khachatoorian, V. Arumugaswami, P. Ruchala, S. Raychaudhuri, E.M. Maloney, E. Miao, and et al. A cell-permeable hairpin peptide inhibits hepatitis C viral nonstructural protein 5A-mediated translation and virus production Hepatology 55 2012 1662 1672
13. R. Khachatoorian, E. Ganapathy, Y. Ahmadieh, N. Wheatley, C. Sundberg, C.L. Jung, and et al. The NS5A-binding heat shock proteins HSC70 and HSP70 play distinct roles in the hepatitis C viral life cycle Virology 454-455 2014 118 127
14. R. Khachatoorian, V. Arumugaswami, S. Raychaudhuri, G.K. Yeh, E.M. Maloney, J. Wang, and et al. Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle Virology 433 2012 346 355
15. A. Rousaki, Y. Miyata, U.K. Jinwal, C.A. Dickey, J.E. Gestwicki, and E.R. Zuiderweg Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones J Mol Biol 411 2011 614 632
16. A.M. Wang, Y. Miyata, S. Klinedinst, H.M. Peng, J.P. Chua, T. Komiyama, and et al. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation Nat Chem Biol 9 2013 112 118
17. J. Abisambra, U.K. Jinwal, Y. Miyata, J. Rogers, L. Blair, X. Li, and et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau Biol Psychiatry 74 2013 367 374
18. M.J. Davis, B. Gregorka, J.E. Gestwicki, and J.A. Swanson Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages J Immunol 189 2012 4488 4495
19. T.A. Colvin, V.L. Gabai, J. Gong, S.K. Calderwood, H. Li, S. Gummuluru, and et al. Hsp70-Bag3 interactions regulate cancer-related signaling networks Cancer Res 74 2014 4731 4740
20. N.N. Du, Z.G. Peng, C.W. Bi, S. Tang, Y.H. Li, J.R. Li, and et al. N-substituted benzyl matrinic acid derivatives inhibit hepatitis C virus (HCV) replication through down-regulating host heat-stress cognate 70 (Hsc70) expression PLoS ONE 8 2013 e58675
21. X. Li, T. Colvin, J.N. Rauch, D. Acosta-Alvear, M. Kampmann, B. Dunyak, and et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer Mol Cancer Ther 14 2015 642 648
22. V. Arumugaswami, R. Remenyi, V. Kanagavel, E.Y. Sue, T. Ngoc Ho, C. Liu, and et al. High-resolution functional profiling of hepatitis C virus genome PLoS Pathog 4 2008 e1000182
23. D. Chu, S. Ren, S. Hu, W.G. Wang, A. Subramanian, D. Contreras, and et al. Systematic analysis of enhancer and critical cis-acting RNA elements in the protein-encoding region of the hepatitis C virus genome J Virol 87 2013 5678 5696
24. C.C. Deocaris, N. Widodo, B.G. Shrestha, K. Kaur, M. Ohtaka, K. Yamasaki, and et al. Mortalin sensitizes human cancer cells to MKT-077-induced senescence Cancer Lett 252 2007 259 269
25. Y. Miyata, X. Li, H.F. Lee, U.K. Jinwal, S.R. Srinivasan, S.P. Seguin, and et al. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels ACS Chem Neurosci 4 2013 930 939
26. X. Li, S.R. Srinivasan, J. Connarn, A. Ahmad, Z.T. Young, A.M. Kabza, and et al. Analogs of the allosteric heat shock protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agents ACS Med Chem Lett 2013 4
27. R. Khachatoorian, P. Ruchala, A. Waring, C.L. Jung, E. Ganapathy, N. Wheatley, and et al. Structural characterization of the HSP70 interaction domain of the hepatitis C viral protein NS5A Virology 475 2015 46 55
28. S.L. Newmyer, and S.L. Schmid Dominant-interfering Hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo J Cell Biol 152 2001 607 620
29. G. Neveu, R. Barouch-Bentov, A. Ziv-Av, D. Gerber, Y. Jacob, and S. Einav Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly PLoS Pathog 8 2012 e1002845