The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia

Cell

Volumn 165, Issue 2, 2016, Pages 343-356

  Okin, Daniel ^a   Medzhitov, Ruslan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOKINE; GLUCOSE; MEVALONIC ACID; PROTEIN KINASE; CYP7A1 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; LIPOPOLYSACCHARIDE; RAS PROTEIN; RHO KINASE; RHOC PROTEIN, MOUSE; TRIACYLGLYCEROL;

ARTICLE; EX VIVO STUDY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INFLAMMATION; LIPID DIET; LIVER CELL; LIVER SIZE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; BLOOD; DIET RESTRICTION; GENETIC TRANSCRIPTION; HEPATITIS; METABOLISM; MOUSE; MOUSE MUTANT; PROTEIN PRENYLATION; TOXIC HEPATITIS;

ANIMALS; BIOSYNTHETIC PATHWAYS; BLOOD GLUCOSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHOLESTEROL 7-ALPHA-HYDROXYLASE; FASTING; HEPATITIS; HYPERGLYCEMIA; LIPOPOLYSACCHARIDES; MEVALONIC ACID; MICE; MICE, OBESE; PROTEIN PRENYLATION; RAS PROTEINS; RHO-ASSOCIATED KINASES; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

EID: 84961221250     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.02.023     Document Type: Article

References (58)

1. U. Alon Network motifs: theory and experimental approaches Nat. Rev. Genet. 8 2007 450 461
2. R.C. Andrews, and B.R. Walker Glucocorticoids and insulin resistance: old hormones, new targets Clin. Sci. 96 1999 513 523
3. M.C. Arkan, A.L. Hevener, F.R. Greten, S. Maeda, Z.-W. Li, J.M. Long, A. Wynshaw-Boris, G. Poli, J. Olefsky, and M. Karin IKK-beta links inflammation to obesity-induced insulin resistance Nat. Med. 11 2005 191 198
4. L.A. Barbour, C.E. McCurdy, T.L. Hernandez, J.P. Kirwan, P.M. Catalano, and J.E. Friedman Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes Diabetes Care 30 2007 S112 S119
5. E.D. Berglund, C.Y. Li, G. Poffenberger, J.E. Ayala, P.T. Fueger, S.E. Willis, M.M. Jewell, A.C. Powers, and D.H. Wasserman Glucose metabolism in vivo in four commonly used inbred mouse strains Diabetes 57 2008 1790 1799
6. N.F. Butte Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus Am. J. Clin. Nutr. 71 2000 1256S 1261S
7. D. Cai, M. Yuan, D.F. Frantz, P.A. Melendez, L. Hansen, J. Lee, and S.E. Shoelson Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-kappaB Nat. Med. 11 2005 183 190
8. A.C. Calkin, and P. Tontonoz Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nat. Rev. Mol. Cell Biol. 13 2012 213 224
9. P.D. Cani, J. Amar, M.A. Iglesias, M. Poggi, C. Knauf, D. Bastelica, A.M. Neyrinck, F. Fava, K.M. Tuohy, C. Chabo, and et al. Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 2007 1761 1772
10. G. Chen, and D.V. Goeddel TNF-R1 signaling: a beautiful pathway Science 296 2002 1634 1635
11. K.H. Chun, K. Araki, Y. Jee, D.H. Lee, B.-C. Oh, H. Huang, K.S. Park, S.W. Lee, J.M. Zabolotny, and Y.-B. Kim Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization Endocrinology 153 2012 1649 1662
12. K.D. Copps, N.J. Hancer, L. Opare-Ado, W. Qiu, C. Walsh, and M.F. White Irs1 serine 307 promotes insulin sensitivity in mice Cell Metab. 11 2010 84 92
13. T.Q. de Aguiar Vallim, E.J. Tarling, and P.A. Edwards Pleiotropic roles of bile acids in metabolism Cell Metab. 17 2013 657 669
14. M.Y. Donath, and S.E. Shoelson Type 2 diabetes as an inflammatory disease Nat. Rev. Immunol. 11 2011 98 107
15. S. Etienne-Manneville, and A. Hall Rho GTPases in cell biology Nature 420 2002 629 635
16. M. Falciglia, R.W. Freyberg, P.L. Almenoff, D.A. D'Alessio, and M.L. Render Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis Crit. Care Med. 37 2009 3001 3009
17. K.R. Feingold, A. Moser, J.K. Shigenaga, and C. Grunfeld Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue Innate Immun. 18 2012 231 240
18. S. Ghosh, M.J. May, and E.B. Kopp NF-κ B and Rel proteins: evolutionarily conserved mediators of immune responses Annu. Rev. Immunol. 16 1998 225 260
19. R.B. Goldberg, V.A. Fonseca, K.E. Truitt, and M.R. Jones Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy Arch. Intern. Med. 168 2008 1531 1540
20. J.L. Goldstein, and M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
21. M.F. Gregor, and G.S. Hotamisligil Inflammatory mechanisms in obesity Annu. Rev. Immunol. 29 2011 415 445
22. G.S. Hotamisligil, P. Peraldi, A. Budavari, R. Ellis, M.F. White, and B.M. Spiegelman IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance Science 271 1996 665 668
23. W. Huang, B.T. Sherman, and R.A. Lempicki Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists Nucleic Acids Res. 37 2009 1 13
24. W. Huang, B.T. Sherman, and R.A. Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat. Protoc. 4 2009 44 57
25. H. Huang, D.H. Lee, J.M. Zabolotny, and Y.-B. Kim Metabolic actions of Rho-kinase in periphery and brain Trends Endocrinol. Metab. 24 2013 506 514
26. A.M.F. Johnson, and J.M. Olefsky The origins and drivers of insulin resistance Cell 152 2013 673 684
27. M.E. Kotas, and R. Medzhitov Homeostasis, inflammation, and disease susceptibility Cell 160 2015 816 827
28. C.A. Lalli, J.R. Pauli, P.O. Prada, D.E. Cintra, E.R. Ropelle, L.A. Velloso, and M.J.A. Saad Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet Metabolism 57 2008 57 65
29. P. Langfelder, and S. Horvath WGCNA: an R package for weighted correlation network analysis BMC Bioinformatics 9 2008 559
30. D.H. Lee, J. Shi, N.H. Jeoung, M.S. Kim, J.M. Zabolotny, S.W. Lee, M.F. White, L. Wei, and Y.-B. Kim Targeted disruption of ROCK1 causes insulin resistance in vivo J. Biol. Chem. 284 2009 11776 11780
31. S.-H. Lee, H. Huang, K. Choi, D.H. Lee, J. Shi, T. Liu, K.H. Chun, J.A. Seo, I.S. Lima, J.M. Zabolotny, and et al. ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance Am. J. Physiol. Endocrinol. Metab. 306 2014 E332 E343
32. J.K. Liao, and U. Laufs Pleiotropic effects of statins Annu. Rev. Pharmacol. Toxicol. 45 2005 89 118
33. H.V. Lin, and D. Accili Hormonal regulation of hepatic glucose production in health and disease Cell Metab. 14 2011 9 19
34. T. Magee, and M.C. Seabra Fatty acylation and prenylation of proteins: what's hot in fat Curr. Opin. Cell Biol. 17 2005 190 196
35. S. Maurer-Stroh, and F. Eisenhaber Refinement and prediction of protein prenylation motifs Genome Biol. 6 2005 R55
36. O.P. McGuinness Defective glucose homeostasis during infection Annu. Rev. Nutr. 25 2005 9 35
37. J.H. Miyake, X.D. Doung, W. Strauss, G.L. Moore, L.W. Castellani, L.K. Curtiss, J.M. Taylor, and R.A. Davis Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase J. Biol. Chem. 276 2001 23304 23311
38. B.A. Mizock Alterations in fuel metabolism in critical illness: hyperglycaemia Best Pract. Res. Clin. Endocrinol. Metab. 15 2001 533 551
39. M. Nakata, S. Nagasaka, I. Kusaka, H. Matsuoka, S. Ishibashi, and T. Yada Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control Diabetologia 49 2006 1881 1892
40. C. Nathan, and A. Ding Nonresolving inflammation Cell 140 2010 871 882
41. J.I. Odegaard, and A. Chawla Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis Science 339 2013 172 177
42. D. Okin, and R. Medzhitov Evolution of inflammatory diseases Curr. Biol. 22 2012 R733 R740
43. J.M. Olefsky, and C.K. Glass Macrophages, inflammation, and insulin resistance Annu. Rev. Physiol. 72 2010 219 246
44. L.R. Pearce, D. Komander, and D.R. Alessi The nuts and bolts of AGC protein kinases Nat. Rev. Mol. Cell Biol. 11 2010 9 22
45. R.J. Perry, V.T. Samuel, K.F. Petersen, and G.I. Shulman The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes Nature 510 2014 84 91
46. J. Prawitt, M. Abdelkarim, J.H.M. Stroeve, I. Popescu, H. Duez, V.R. Velagapudi, J. Dumont, E. Bouchaert, T.H. van Dijk, A. Lucas, and et al. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity Diabetes 60 2011 1861 1871
47. L.M. Redman, and E. Ravussin Endocrine alterations in response to calorie restriction in humans Mol. Cell. Endocrinol. 299 2009 129 136
48. P.M. Ridker, A. Pradhan, J.G. MacFadyen, P. Libby, and R.J. Glynn Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial Lancet 380 2012 565 571
49. N. Sattar, D. Preiss, H.M. Murray, P. Welsh, B.M. Buckley, A.J.M. de Craen, S.R.K. Seshasai, J.J. McMurray, D.J. Freeman, J.W. Jukema, and et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials Lancet 375 2010 735 742
50. G.I. Shulman Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease N. Engl. J. Med. 371 2014 1131 1141
51. D.H. Solomon, T.J. Love, C. Canning, and S. Schneeweiss Risk of diabetes among patients with rheumatoid arthritis, psoriatic arthritis and psoriasis Ann. Rheum. Dis. 69 2010 2114 2117
52. D.H. Solomon, E. Massarotti, R. Garg, J. Liu, C. Canning, and S. Schneeweiss Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis JAMA 305 2011 2525 2531
53. B. Staels, and V.A. Fonseca Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration Diabetes Care 32 2009 S237 S245
54. I. Tabas Consequences of cellular cholesterol accumulation: basic concepts and physiological implications J. Clin. Invest. 110 2002 905 911
55. C. Thomas, R. Pellicciari, M. Pruzanski, J. Auwerx, and K. Schoonjans Targeting bile-acid signalling for metabolic diseases Nat. Rev. Drug Discov. 7 2008 678 693
56. C. Thomas, A. Gioiello, L. Noriega, A. Strehle, J. Oury, G. Rizzo, A. Macchiarulo, H. Yamamoto, C. Mataki, M. Pruzanski, and et al. TGR5-mediated bile acid sensing controls glucose homeostasis Cell Metab. 10 2009 167 177
57. A.P. Wheeler, and A.J. Ridley Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility Exp. Cell Res. 301 2004 43 49
58. F.L. Zhang, and P.J. Casey Protein prenylation: molecular mechanisms and functional consequences Annu. Rev. Biochem. 65 1996 241 269