Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue

Innate Immunity

Volumn 18, Issue 2, 2012, Pages 231-240

  Feingold, Kenneth R ^a   Moser, Arthur ^a   Shigenaga, Judy K ^a   Grunfeld, Carl ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

IL 1; LPS; PPAR ; TNF ; turpentine; zymosan

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RETINOID X RECEPTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TURPENTINE; ZYMOSAN;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; INFLAMMATION; KNOCKOUT MOUSE; LIVER; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

3T3-L1 CELLS; ADIPOSE TISSUE; ANIMALS; CYTOKINES; DNA, COMPLEMENTARY; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCONEOGENESIS; INFLAMMATION; LIPOLYSIS; LIPOPOLYSACCHARIDES; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOENOLPYRUVATE CARBOXYLASE; PPAR GAMMA; REAL-TIME POLYMERASE CHAIN REACTION; RETINOID X RECEPTOR ALPHA; RNA; TOLL-LIKE RECEPTOR 4; TURPENTINE; ZYMOSAN;

ANIMALIA; MUS;

EID: 84858396330     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425911398678     Document Type: Article

References (52)

1. Baumann H, Gauldie J. The acute phase response. Immunol Today. 1994 ; 15: 74-80 (Pubitemid 24049800)
2. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999 ; 340: 448-454 (Pubitemid 29084777)
3. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006 ; 444: 860-867 (Pubitemid 46024993)
4. Libby P. Inflammation in atherosclerosis. Nature. 2002 ; 420: 868-874 (Pubitemid 36019640)
5. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diab Care. 2004 ; 27: 813-823 (Pubitemid 38280558)
6. Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 ; 118: 2992-3002
7. Khovidhunkit W, Kim MS, Memon RA, et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res. 2004 ; 45: 1169-1196 (Pubitemid 38802622)
8. Spitzer JJ. Bacterial endotoxin effects on carbohydrate utilization and transport. Biochem Soc Trans. 1995 ; 23: 998-1002
9. Bagby GJ, Corll CB, Martinez RR. Triacylglycerol kinetics in endotoxic rats with suppressed lipoprotein lipase activity. Am J Physiol. 1987 ; 253: E59 - E64
10. Feingold KR, Staprans I, Memon RA, et al. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res. 1992 ; 33: 1765-1776 (Pubitemid 23006653)
11. Gouni I, Oka K, Etienne J, Chan L. Endotoxin-induced hypertriglyceridemia is mediated by suppression of lipoprotein lipase at a post-transcriptional level. J Lipid Res. 1993 ; 34: 139-146 (Pubitemid 23016629)
12. Grunfeld C, Gulli R, Moser AH, Gavin LA, Feingold KR. Effect of tumor necrosis factor administration in vivo on lipoprotein lipase activity in various tissues of the rat. J Lipid Res. 1989 ; 30: 579-585 (Pubitemid 19107744)
13. Lanza-Jacoby S, Tabares A. Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats. Am J Physiol. 1990 ; 258: E678 - E85
14. Lanza-Jacoby S, Rosato E, Braccia G, Tabares A. Altered ketone body metabolism during gram-negative sepsis in the rat. Metabolism. 1990 ; 39: 1151-1157 (Pubitemid 20376345)
15. Takeyama N, Itoh Y, Kitazawa Y, Tanaka T. Altered hepatic mitochondrial fatty acid oxidation and ketogenesis in endotoxic rats. Am J Physiol. 1990 ; 259: E498 - E505 (Pubitemid 20340365)
16. Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg AS. Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes. 2002 ; 51: 2929-2935
17. Brasaemle DL. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res. 2007 ; 48: 2547-2559 (Pubitemid 350272839)
18. Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 2009 ; 50: 3-21
19. Souza SC, de Vargas LM, Yamamoto MT, et al. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J Biol Chem. 1998 ; 273: 24665-24669 (Pubitemid 28454965)
20. Lu B, Lu Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2008 ; 295: E1502 - E1509
21. Lu B, Moser AH, Shigenaga JK, Feingold KR, Grunfeld C. Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response. J Lipid Res. 2006 ; 47: 2179-2190 (Pubitemid 44936128)
22. Memon RA, Fuller J, Moser AH, Smith PJ, Feingold KR, Grunfeld C. In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines. Am J Physiol. 1998 ; 275: E64 - E72
23. Hanson RW, Reshef L. Glyceroneogenesis revisited. Biochimie. 2003 ; 85: 1199-1205 (Pubitemid 38096343)
24. Yang J, Kalhan SC, Hanson RW. What is the metabolic role of phosphoenolpyruvate carboxykinase?. J Biol Chem. 2009 ; 284: 27025-27029
25. Margolis S, Vaughan M. Alpha-Glycerophosphate synthesis and breakdown in homogenates of adipose tissue. J Biol Chem. 1962 ; 237: 44-48
26. Nye CK, Hanson RW, Kalhan SC. Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat. J Biol Chem. 2008 ; 283: 27565-276574
27. Nordlie RC, Lardy HA. Mammalian liver phosphoneolpyruvate carboxykinase activities. J Biol Chem. 1963 ; 238: 2259-2263
28. Hill M, McCallum R. Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment. J Clin Invest. 1991 ; 88: 811-816
29. Hill MR, McCallum RE. Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment of mice. Infect Immun. 1992 ; 60: 4040-4050
30. McCallum RE, Seale TW, Stith RD. Influence of endotoxin treatment on dexamethasone induction of hepatic phosphoenolpyruvate carboxykinase. Infect Immun. 1983 ; 39: 213-219 (Pubitemid 13212518)
31. Rippe DF, Berry LJ. Study of inhibition of induction of phosphoenolpyruvate carboxykinase by endotoxin with radial immunodiffusion. Infect Immun. 1972 ; 6: 766-772
32. Wang K, Deutschman CS, Clemens MG, De Maio A. Reciprocal expression of phosphoenolpyruvate carboxykinase and acute phase genes during acute inflammation. Shock. 1995 ; 3: 204-209
33. Beale EG, Forest C, Hammer RE. Regulation of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes. Biochimie. 2003 ; 85: 1207-1211 (Pubitemid 38096344)
34. Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem. 1997 ; 66: 581-611 (Pubitemid 27274668)
35. Patton JS, Shepard HM, Wilking H, et al. Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proc Nat Acad Sci USA. 1986 ; 83: 8313-8317 (Pubitemid 17182491)
36. Musri MM, Gomis R, Parrizas M. Application of electrophoretic mobility shift assay and chromatin immunoprecipitation in the study of transcription in adipose cells. Meth Mol Biol. 2008 ; 456: 231-247
37. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. The acute phase response is associated with retinoid X receptor repression in rodent liver. J Biol Chem. 2000 ; 275: 16390-16399 (Pubitemid 30366957)
38. Faggioni R, Jones-Carson J, Reed DA, et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Nat Acad Sci USA. 2000 ; 97: 2367-2372 (Pubitemid 30134075)
39. Feingold KR, Wang Y, Moser A, Shigenaga JK, Grunfeld C. LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney. J Lipid Res. 2008 ; 49: 2179-2187
40. Sato M, Sano H, Iwaki D, et al. Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J Immunol. 2003 ; 171: 417-425 (Pubitemid 36745315)
41. Underhill DM. Macrophage recognition of zymosan particles. J Endotoxin Res. 2003 ; 9: 176-180 (Pubitemid 36722597)
42. Gershenwald JE, Fong YM, Fahey TJ, et al. Interleukin 1 receptor blockade attenuates the host inflammatory response. Proc Nat Acad Sci USA. 1990 ; 87: 4966-4970
43. Zheng H, Fletcher D, Kozak W, et al. Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice. Immunity. 1995 ; 3: 9-19
44. Hill MR, Young MD, McCurdy CM, Gimble JM. Decreased expression of murine PPARgamma in adipose tissue during endotoxemia. Endocrinology. 1997 ; 138: 3073-3076
45. Fischer KF, Lees JA, Newman JH. Hypoglycemia in hospitalized patients. Causes and outcomes. N Engl J Med. 1986 ; 315: 1245-1250 (Pubitemid 17049682)
46. Groves AC, Woolf LI, O'Regan PJ, Beach C, Hasinoff C, Sutherland WH. Impaired gluconeogenesis in dogs with E. coli bacteremia. Surgery. 1974 ; 76: 533-541
47. Wilmore DW. Impaired gluconeogenesis in extensively injured patients with gram-negative bacteremia. Am J Clin Nutr. 1977 ; 30: 1355-1356 (Pubitemid 8179613)
48. Chang CK, Gatan M, Schumer W. Efficacy of anti-tumor necrosis factor polyclonal antibody on phosphoenolpyruvate carboxykinase expression in septic and endotoxemic rats. Shock. 1996 ; 6: 57-60 (Pubitemid 126727729)
49. Faggioni R, Moser A, Feingold KR, Grunfeld C. Reduced leptin levels in starvation increase susceptibility to endotoxic shock. Am J Path. 2000 ; 156: 1781-1787 (Pubitemid 30646715)
50. Spitzer JJ, Bagby GJ, Meszaros K, Lang CH. Altered control of carbohydrate metabolism in endotoxemia. Prog Clin Biol Res. 1989 ; 286: 145-165
51. Tordjman J, Khazen W, Antoine B, et al. Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes. Biochimie. 2003 ; 85: 1213-1218 (Pubitemid 38096345)
52. Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, Scherer PE. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem. 2000 ; 275: 24255-24263 (Pubitemid 30626513)