PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

Nature Medicine

Volumn 22, Issue 4, 2016, Pages 379-387

  Shojaee, Seyedmehdi ^a   Chan, Lai N ^a   Buchner, Maike ^a   Cazzaniga, Valeria ^a,b   Cosgun, Kadriye Nehir ^a   Geng, Huimin ^a   Qiu, Yi Hua ^c   Von Minden, Marcus Dühren ^d   Ernst, Thomas ^e   Hochhaus, Andreas ^e   Cazzaniga, Giovanni ^b   Melnick, Ari ^f   Kornblau, Steven M ^c   Graeber, Thomas G ^g   Wu, Hong ^g   Jumaa, Hassan ^d   Müschen, Markus ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF ULM   (Germany)

^e JENA UNIVERSITY HOSPITAL   (Germany)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PRE B CELL RECEPTOR; PROTEIN KINASE B; PROTEIN P53; PHOSPHATIDYLINOSITOL 3 KINASE; PTEN PROTEIN, MOUSE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE CHECKPOINT; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMOGENESIS; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SUPPRESSOR CELL; ANIMAL; B LYMPHOCYTE; DRUG RESISTANCE; GENETICS; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; B-LYMPHOCYTES; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; MICE; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 3-KINASES; PRE-B CELL RECEPTORS; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 84961219276     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4062     Document Type: Article

References (35)

1. Osmond, D.G. Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr. Opin. Immunol. 3, 179-185 (1991
2. Wardemann, H., et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374-1377 (2003
3. Keenan, R.A., et al. Censoring of autoreactive B cell development by the pre-B cell receptor. Science 321, 696-699 (2008
4. Srinivasan, L., et al. PI3 kinase signals BCR-dependent mature B cell survival. Cell 139, 573-586 (2009
5. Ramadani, F., et al. The PI3K isoforms p110-α and p110-d are essential for pre-B cell receptor signaling and B cell development. Sci. Signal. 3, ra60 (2010
6. Deau, M.C., et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. J. Clin. Invest. 124, 3923-3928 (2014
7. Vivanco, I., & Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501 (2002
8. Futreal, P.A., et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177-183 (2004
9. Gutierrez, A., et al. High frequency of PTEN, PI3K and AKT abnormalities in T cell acute lymphoblastic leukemia. Blood 114, 647-650 (2009
10. Lesche, R., et al. Cre-loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 32, 148-149 (2002
11. Zhang, J., et al. Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood 118, 3080-3087 (2011
12. Guo, B., Kato, R.M., Garcia-Lloret, M., Wahl, M.I., & Rawlings, D.J. Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. Immunity 13, 243-253 (2000
13. Okada, T., Maeda, A., Iwamatsu, A., Gotoh, K., & Kurosaki, T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 13, 817-827 (2000
14. Anzelon, A.N., Wu, H., & Rickert, R.C. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat. Immunol. 4, 287-294 (2003
15. Aiba, Y., Kameyama, M., Yamazaki, T., Tedder, T.F., & Kurosaki, T. Regulation of B cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 111, 1497-1503 (2008
16. Tesio, M., et al. Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization. J. Exp. Med. 210, 2337-2349 (2013
17. Peng, C., et al. PTEN is a tumor suppressor in CML stem cells and in BCR-ABL-induced leukemias in mice. Blood 115, 626-635 (2010
18. Li, J., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science 275, 1943-1947 (1997
19. Gutierrez, A., et al. Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J. Exp. Med. 208, 1595-1603 (2011
20. Lenz, G., et al. Molecular subtypes of diffuse large B cell lymphoma arise by distinct genetic pathways. Proc. Natl. Acad. Sci. USA 105, 13520-13525 (2008
21. Miletic, A.V., et al. Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases. J. Exp. Med. 207, 2407-2420 (2010
22. Pfeifer, M., et al. PTEN loss defines a PI3K-AKT pathway-dependent germinal center subtype of diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA 110, 12420-12425 (2013
23. Tibes, R., et al. Reverse-phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol. Cancer Ther. 5, 2512-2521 (2006
24. Roman-Gomez, J., et al. Lack of CpG island methylator phenotype defines a clinical subtype of T cell acute lymphoblastic leukemia associated with good prognosis. J. Clin. Oncol. 23, 7043-7049 (2005
25. Chen, Z., et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005
26. Köhler, F., et al. Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells. Immunity 29, 912-921 (2008
27. Xie, H., Ye, M., Feng, R., & Graf, T. Stepwise reprogramming of B cells into macrophages. Cell 117, 663-676 (2004
28. Shackelford, D.B., et al. mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc. Natl. Acad. Sci. USA 106, 11137-11142 (2009
29. Düvel, K., et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39, 171-183 (2010
30. Rosivatz, E., et al. A small-molecule inhibitor for phosphatase and tensin homolog deleted on chromosome 10 (PTEN). ACS Chem. Biol. 1, 780-790 (2006
31. Li, Y., et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117, 6702-6713 (2011
32. Chen, Z., et al. Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia. Nature 521, 357-361 (2015
33. Shojaee, S., et al. Erk negative feedback control enables pre B cell transformation and represents a therapeutic target in acute lymphoblastic leukemia. Cancer Cell 28, 114-128 (2015
34. Kharas, M.G., et al. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K-mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J. Clin. Invest. 118, 3038-3050 (2008
35. Khulan, B., et al. Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res. 16, 1046-1055 (2006