Cause of trauma-induced coagulopathy

Current Opinion in Anaesthesiology

Volumn 29, Issue 2, 2016, Pages 212-219

  Davenport, Ross A ^a   Brohi, Karim ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

bleeding; coagulopathy; fibrinolysis; haemorrhage; trauma

Indexed keywords

ACTIVATED PROTEIN C; FIBRINOGEN; PROTEIN C; THROMBIN;

BLOOD CLOTTING; BLOOD CLOTTING DISORDER; ENDOTHELIUM; FIBRINOLYSIS; HEMOSTASIS; HUMAN; INJURY; PERFUSION; PLATELET MICROPARTICLE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; THROMBOCYTE DYSFUNCTION; TISSUE INJURY; TRAUMA INDUCED COAGULOPATHY; BLOOD COAGULATION DISORDERS; COMPLICATION; MEMBRANE MICROPARTICLE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; SYNDROME; THROMBOCYTE;

BLOOD COAGULATION DISORDERS; BLOOD PLATELETS; CELL-DERIVED MICROPARTICLES; ENDOTHELIUM; FIBRINOGEN; FIBRINOLYSIS; HEMOSTASIS; HUMANS; PROTEIN C; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; SYNDROME; THROMBIN; WOUNDS AND INJURIES;

EID: 84961218107     PISSN: 09527907     EISSN: 14736500     Source Type: Journal    
DOI: 10.1097/ACO.0000000000000295     Document Type: Review

References (81)

1. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: An analysis from the German Trauma Registry on 8724 patients. Injury 2007; 38:298-304.
2. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma 2003; 54:1127-1130.
3. MacLeod JB, Lynn M, McKenney MG, et al. Early coagulopathy predicts mortality in trauma. J Trauma 2003; 55:39-44.
4. Dobson GP, Letson HL, Sharma R, et al. Mechanisms of early trauma-induced coagulopathy: The clot thickens or not? J Trauma Acute Care Surg 2015; 79:301-309.
5. Frith D, Goslings JC, Gaarder C, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 2010; 8:1919-1925.
6. Cohen MJ, Kutcher M, Redick B, et al. Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg 2013; 75:S40-S47.
7. Cotton BA, Reddy N, Hatch QM, et al. Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients. Ann Surg 2011; 254:598-605.
8. Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial. JAMA 2015; 313:471-482.
9. Floccard B, Rugeri L, Faure A, et al. Early coagulopathy in trauma patients: An on-scene and hospital admission study. Injury 2010; 43:26-32.
10. Davenport R, Manson J, DeAth H, et al. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med 2011; 39:2652-2658.
11. Brohi K, Cohen MJ, Ganter MT, et al. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 2007; 245:812-818.
12. Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma 2008; 64:1211-1217.
13. Wohlauer MV, Moore EE, Droz NM, et al. Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma. J Surg Res 2012; 173:26-30.
14. Wafaisade A, Wutzler S, Lefering R, et al. Trauma Registry of DGU: drivers of acute coagulopathy after severe trauma: A multivariate analysis of 1987 patients. Emerg Med J 2010; 27:934-939.
15. Roberts HR, Hoffman M, Monroe DM. A cell-based model of thrombin generation. Semin Thromb Hemost 2006; 32 (Suppl 1):32-38.
16. Rizoli S, Nascimento B Jr, Key N, et al. Disseminated intravascular coagulopathy in the first 24 h after trauma: The association between ISTH score and anatomopathologic evidence. J Trauma 2011; 71:S441-S447.
17. Dunbar NM, Chandler WL. Thrombin generation in trauma patients. Transfusion 2009; 49:2652-2660.
18. Cardenas JC, Rahbar E, Pommerening MJ, et al. Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma. J Trauma Acute Care Surg 2014; 77:839-845.
19. Matijevic N, Wang YW, Wade CE, et al. Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy. Thromb Res 2014; 134:652-658.
20. Maegele M, Zinser M, Schlimp C, et al. Injectable hemostatic adjuncts in trauma: fibrinogen and the FIinTIC study. J Trauma Acute Care Surg 2015; 78:S76-S82.
21. Schochl H, Nienaber U, Hofer G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM(R))-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010; 14:R55.
22. Stinger HK, Spinella PC, Perkins JG, et al. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma 2008; 64:S79-S85.
23. Rourke C, Curry N, Khan S, et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 2012; 10:1342-1351.
24. Curry N, Rourke C, Davenport R, et al. Early cryoprecipitate for major haemorrhage in trauma: A randomised controlled feasibility trial. Br J Anaesth 2015; 115:76-83.
25. Morrison JJ, Ross JD, Dubose JJ, et al. Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study. JAMA Surg 2013; 148:218-225.
26. Schochl H, Cotton B, Inaba K, et al. FIBTEM provides early prediction of massive transfusion in trauma. Crit Care 2011; 15:R265.
27. Inaba K, Karamanos E, Lustenberger T, et al. Impact of fibrinogen levels on outcomes after acute injury in patients requiring a massive transfusion. J Am Coll Surg 2013; 216:290-297.
28. Hagemo JS, Jorgensen JJ, Ostrowski SR, et al. Changes in fibrinogen availability and utilization in an animal model of traumatic coagulopathy. Scand J Trauma Resusc Emerg Med 2013; 21:56.
29. Deras P, Villiet M, Manzanera J, et al. Early coagulopathy at hospital admission predicts initial or delayed fibrinogen deficit in severe trauma patients. J Trauma Acute Care Surg 2014; 77:433-440.
30. Hagemo JS, Stanworth S, Juffermans NP, et al. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: A multicentre observational study. Crit Care 2014; 18:R52.
31. Spahn DR, Bouillon B, Cerny V, et al. Management of bleeding and coagulopathy following major trauma: An updated European guideline. Crit Care 2013; 17:R76.
32. Hunt BJ, Allard S, Keeling D, et al. British Committee for Standards in H: A practical guideline for the haematological management of major haemorrhage. Br J Haematol 2015; 170:788-803.
33. Harr JN, Moore EE, Ghasabyan A, et al. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock 2013; 39:45-49.
34. Martini WZ. Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability. J Trauma 2009; 67:202-208.
35. Kremers RM, Wagenvoord RJ, Hemker HC. The effect of fibrin(ogen) on thrombin generation and decay. Thromb Haemost 2014; 112:486-494.
36. Sawamura A, Hayakawa M, Gando S, et al. Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality. Thromb Res 2009; 124:608-613.
37. Cohen MJ, Call M, Nelson M, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 2012; 255:379-385.
38. Ostrowski SR, Sorensen AM, Larsen CF, Johansson PI. Thrombelastography and biomarker profiles in acute coagulopathy of trauma: A prospective study. Scand J Trauma Resusc Emerg Med 2011; 19:64.
39. Esmon CT. The protein C pathway. Chest 2003; 124:26S-32S.
40. Rizoli SB, Scarpelini S, Callum J, et al. Clotting factor deficiency in early trauma-Associated coagulopathy. J Trauma 2011; 71:S427-S434.
41. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg 2011; 254:194-200.
42. Jansen JO, Scarpelini S, Pinto R, et al. Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity. J Trauma 2011; 71:S435-S440.
43. Hayakawa M, Sawamura A, Gando S, et al. Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase. Surgery 2011; 149:221-230.
44. Gando S, Sawamura A, Hayakawa M. Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature. Ann Surg 2011; 254:10-19.
45. Campbell JE, Meledeo MA, Cap AP. Comparative response of platelet fV and plasma fV to activated protein C and relevance to a model of acute traumatic coagulopathy. PLoS One 2014; 9:e99181.
46. Kutcher ME, Ferguson AR, Cohen MJ. A principal component analysis of coagulation after trauma. J Trauma Acute Care Surg 2013; 74:1223-1229.
47. Chin TL, Moore EE, Moore HB, et al. A principal component analysis of postinjury viscoelastic assays: clotting factor depletion versus fibrinolysis. Surgery 2014; 156:570-577.
48. Cotton BA, Harvin JA, Kostousouv V, et al. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg 2012; 73:365-370.
49. Levrat A, Gros A, Rugeri L, et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth 2008; 100:792-797.
50. Ives C, Inaba K, Branco BC, et al. Hyperfibrinolysis elicited via thromboelastography predicts mortality in trauma. J Am Coll Surg 2012; 215:496-502.
51. Raza I, Davenport R, Rourke C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 2013; 11:307-314.
52. Cardenas JC, Matijevic N, Baer LA, et al. Elevated tissue plasminogen activator and reduced plasminogen activator inhibitor promote hyperfibrinolysis in trauma patients. Shock 2014; 41:514-521.
53. Schochl H, Frietsch T, Pavelka M, Jambor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 2009; 67:125-131.
54. Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 2010; 376:23-32.
55. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 2012; 147:113-119.
56. Ausset S, Glassberg E, Nadler R, et al. Tranexamic acid as part of remote damage-control resuscitation in the prehospital setting: A critical appraisal of the medical literature and available alternatives. J Trauma Acute Care Surg 2015; 78:S70-S75.
57. Moore EE, Moore HB, Gonzalez E, et al. Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid. J Trauma Acute Care Surg 2015; 78:S65-S69.
58. Moore HB, Moore EE, Gonzalez E, et al. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: The spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg 2014; 77:811-817.
59. Yanagida Y, Gando S, Sawamura A, et al. Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma-shock. Surgery 2013; 154:48-57.
60. Gando S, Wada H, Thachil J. Scientific, Standardization Committee on DICotISoT, Haemostasis: differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS). J Thromb Haemost 2013; 11:826-835.
61. Johansson PI, Sorensen AM, Perner A, et al. Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Crit Care 2011; 15:R272.
62. Viersen VA, Greuters S, Korfage AR, et al. Hyperfibrinolysis in out of hospital cardiac arrest is associated with markers of hypoperfusion. Resuscitation 2012; 83:1451-1455.
63. Schochl H, Cadamuro J, Seidl S, et al. Hyperfibrinolysis is common in out-ofhospital cardiac arrest: results from a prospective observational thromboelastometry study. Resuscitation 2013; 84:454-459.
64. van Hinsbergh VW, Bertina RM, van Wijngaarden A, et al. Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium. Blood 1985; 65:444-451.
65. Moore HB, Moore EE, Lawson PJ, et al. Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery 2015; 158:386-392.
66. Moore HB, Moore EE, Gonzalez E, et al. Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury. Shock 2015; 43:39-46.
67. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. High circulating adrenaline levels at admission predict increased mortality after trauma. J Trauma Acute Care Surg 2012; 72:428-436.
68. Hunt BJ, Jurd KM. Endothelial cell activation. A central pathophysiological process. BMJ 1998; 316:1328-1329.
69. Senzolo M, Coppell J, Cholongitas E, et al. The effects of glycosaminoglycans on coagulation: A thromboelastographic study. Blood Coagul Fibrinolysis 2007; 18:227-236.
70. Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg 2012; 73:60-66.
71. Kozar RA, Peng Z, Zhang R, et al. Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock. Anesth Analg 2011; 112:1289-1295.
72. Kornblith LZ, Kutcher ME, Redick BJ, et al. Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis. J Trauma Acute Care Surg 2014; 76:255-256.
73. Stansbury LG, Hess AS, Thompson K, et al. The clinical significance of platelet counts in the first 24 h after severe injury. Transfusion 2013; 53:783-789.
74. Holcomb JB, Wade CE, Michalek JE, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008; 248:447-458.
75. Zink KA, Sambasivan CN, Holcomb JB, et al. A high ratio of plasma and platelets to packed red blood cells in the first 6 h of massive transfusion improves outcomes in a large multicenter study. Am J Surg 2009; 197:565-570.
76. Solomon C, Traintinger S, Ziegler B, et al. Platelet function following trauma. A multiple electrode aggregometry study. Thromb Haemost 2011; 106:322-330.
77. Kutcher ME, Redick BJ, McCreery RC, et al. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg 2012; 73:13-19.
78. Moore HB, Moore EE, Chapman MP, et al. Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-Type plasminogen activator in trauma patients. J Thromb Haemost 2015; 13:1878-1887.
79. Windelov NA, Sorensen AM, Perner A, et al. Platelet aggregation following trauma: A prospective study. Blood Coagul Fibrinolysis 2014; 25:67-73.
80. Park MS, Xue A, Spears GM, et al. Thrombin generation and procoagulant microparticle profiles after acute trauma: A prospective cohort study. J Trauma Acute Care Surg 2015; 5:726-731.
81. Curry N, Raja A, Beavis J, et al. Levels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality. J Extracell Vesicles 2014; 3:25625.