Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: Evolving concepts of the spectrum of fibrinolysis in response to severe injury

Shock

Volumn 43, Issue 1, 2015, Pages 39-46

  Moore, Hunter B ^a   Moore, Ernest E ^a,b   Gonzalez, Eduardo ^a   Hansen, Kirk C ^a   Dzieciatkowska, Monika ^a   Chapman, Michael P ^a   Sauaia, Angela ^a   West, Bernadette ^a,c   Banerjee, Anirban ^a   Silliman, Christopher C ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b DENVER HEALTH MEDICAL CENTER   (United States)

^c Bonfils Blood Center   (United States)

Author keywords

Fibrinolysis shutdown; Hemolysis; Hyperfibrinolysis; Platelets; Red blood cells; Trauma induced coagulopathy

Indexed keywords

26S PROTEASOME NON ATPASE REGULATORY SUBUNIT 3; ALPHA ENOLASE; ATP SYNTHASE SUBUNIT ALPHA; BETA3 INTEGRIN; BLOOD CLOTTING FACTOR 5; CALMODULIN; CELL PROTEIN; COP9 SIGNALOSOME COMPLEX SUBUNIT 4; FIBRONECTIN; HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN 1; LIM AND SENESCENT CELL ANTIGEN LIKE PROTEIN; LIQUID NITROGEN; MULTIMERIN 1; PADGEM PROTEIN; PEROXIREDOXIN 4; PLASMA PROTEIN; PLASMINOGEN; PLECKSTRIN; PROHIBITIN 2; PROTEIN DDI1 HOMOLOG 2; PUTATIVE DEOXYRIBOSE PHOSPHATE ALDOLASE; SH3 DOMAIN BINDING GLUTAMIC ACID RICH PROTEIN; T COMPLEX PROTEIN 1 SUBUNIT GAMMA; TISSUE PLASMINOGEN ACTIVATOR; TRANSLIN; TRANSLIN ASSOCIATED PROTEIN X; TROPOMODULIN; UBIQUITIN CARBOXYL TERMINAL HYDROLASE 14; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; BLOOD CLOTTING DISORDER; BLOOD DONOR; CELL LYSATE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; ERYTHROCYTE; EX VIVO STUDY; FIBRINOLYSIS; FROZEN SECTION; HEMOLYSIS; HEMORRHAGIC SHOCK; HUMAN; HUMAN CELL; HYPERFIBRINOLYSIS; IMMOBILIZATION; INJURY SEVERITY; ISCHEMIA; LIQUID CHROMATOGRAPHY; MEMBRANE DAMAGE; PLATELOLYSIS; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; TANDEM MASS SPECTROMETRY; THROMBOCYTE DISORDER; THROMBOELASTOGRAPHY; ADULT; AGED; BLOOD; CLINICAL TRIAL; INJURY; MALE; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; THROMBOCYTE;

ADULT; AGED; BLOOD PLATELETS; ERYTHROCYTES; FIBRINOLYSIS; HEMOLYSIS; HUMANS; MALE; MIDDLE AGED; TISSUE PLASMINOGEN ACTIVATOR; WOUNDS AND INJURIES;

EID: 84925880273     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000245     Document Type: Conference Paper

References (35)

1. Chakrabarti R, Hocking ED, Fearnley GR: Reaction pattern to three stressesVelectroplexy, surgery, and myocardial infarctionVof fibrinolysis and plasma fibrinogen. J Clin Pathol 22:659-662, 1969.
2. Brohi K, Cohen MJ, Davenport RA: Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13:680-685, 2007.
3. Kutcher ME, Ferguson AR, Cohen MJ: A principal component analysis of coagulation after trauma. J Trauma Acute Care Surg 74:1223-1229, 2013; discussion 1229-1230.
4. Cotton BA, Harvin JA, Kostousouv V, Minei KM, Radwan ZA, Schochl H, Wade CE, Holcomb JB, Matijevic N: Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg 73:365-370, 2012; discussion 370.
5. Chapman MP, Moore EE, Ramos CR, Ghasabyan A, Harr JN, et al. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg 75:961-967, 2013.
6. Schochl H, Frietsch T, Pavelka M, Jambor C: Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 67:125-131, 2013.
7. Hardaway RM: Disseminated intravascular coagulation with special reference to shock and its treatment. Mil Med 130:451-460, 1965.
8. Moore HB ME, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A: Hyperfibrinolysis, physiologic fibrinolysis, fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and the relevance to antifibrinolytic therapy. J Trauma Acute Care Surg. 2014 Jul 21. [Epub ahead of print].
9. Park MS, Owen BA, Ballinger BA, Sarr MG, Schiller HJ, et al. Quantification of hypercoagulable state after blunt trauma: microparticle and thrombin generation are increased relative to injury severity, while standard markers are not. Surgery 151:831-836, 2012.
10. Salooja N, Perry DJ: Thrombelastography. Blood Coagul Fibrinolysis 12: 327-337, 2001.
11. Bovill EG, Tracy RP, Hayes TE, Jenny RJ, Bhushan FH, et al. Evidence that meizothrombin is an intermediate product in the clotting of whole blood. Arterioscler Thromb Vasc Biol 15:754-758, 1995.
12. Whelihan MF, Mooberry MJ, Zachary V, Bradford RL, Ataga KI, et al. The contribution of red blood cells to thrombin generation in sickle cell disease: meizothrombin generation on sickled red blood cells. J Thromb Haemost 11:2187-2189, 2013.
13. Jy W, Johansen ME, Bidot C Jr, Horstman LL, Ahn YS: Red cell-derived micro-particles (RMP) as haemostatic agent. Thromb Haemost 110:751-760, 2013.
14. Amer J, Weiss L, Reich S, Shapira MY, Slavin S, et al. The oxidative status of blood cells in a murine model of graft-versus-host disease. Ann Hematol 86:753-758, 2007.
15. Sharma S, Zingde SM, Gokhale SM: Identification of human erythrocyte cy-tosolic proteins associated with plasma membrane during thermal stress. J Membr Biol 246:591-607, 2013.
16. Lang F, Abed M, Lang E, Foller M: Oxidative stress and suicidal erythrocyte death. Antioxid Redox Signal 21:138-53, 2014.
17. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood 103: 2096-2104, 2004.
18. Stalker TJ, Traxler EA, Wu J, Wannemacher KM, Cermignano SL, et al. Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood 121:1875-1885, 2013.
19. Cattaneo M, Kinlough-Rathbone RL, Lecchi A, Bevilacqua C, Packham MA, et al. Fibrinogen-independent aggregation and deaggregation of human platelets: studies in two afibrinogenemic patients. Blood 70:221-226, 1987.
20. Brass LF, Zhu L, Stalker TJ: Minding the gaps to promote thrombus growth and stability. J Clin Invest 115:3385-3392, 2005.
21. Plow EF, Doeuvre L, Das R: So many plasminogen receptors: why? J Biomed Biotechnol 2012:141806, 2012.
22. Fukao H, Hagiya Y, Ueshima S, Okada K, Takaishi T, et al. Effect of heat shock on the expression of urokinase-type plasminogen activator receptor in human umbilical vein endothelial cells. Thromb Haemost 75:352-358, 1996.
23. Bendig MM, Stephens PE, Cockett MI, Hentschel CC: Mouse cell lines that use heat shock promoters to regulate the expression of tissue plasminogen activator. DNA 6:343-352, 1987.
24. da Rocha AB, Zanoni C, de Freitas GR, Andre C, Himelfarb S, et al. Serum Hsp70 as an early predictor of fatal outcome after severe traumatic brain injury in males. J Neurotrauma 22:966-977, 2005.
25. Cho J, Mosher DF: Role of fibronectin assembly in platelet thrombus formation. J Thromb Haemost 4:1461-1469, 2006.
26. Cho J, Mosher DF: Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi. Blood 107:3555-3563, 2006.
27. Ramanathan A, Karuri N: Fibronectin alters the rate of formation and structure of the fibrin matrix. Biochem Biophys Res Commun 443: 395-399, 2014.
28. Brugge JM, Simioni P, Bernardi F, Tormene D, Lunghi B, et al. Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation. J Thromb Haemost 3: 2695-2702, 2005.
29. Koncz Z, Bagoly Z, Haramura G, Mezei ZA, Muszbek L: Thrombomodulin-dependent effect of factor V Leiden mutation on factor XIII activation. Thromb Res 129:508-513, 2012.
30. Koncz Z, Bagoly Z, Haramura G, Mezei ZA, Muszbek L: Thrombomodulin-dependent effect of factor V Leiden mutation on the cross-linking of alpha2-plasmin inhibitor to fibrin and its consequences on fibrinolysis. Thromb Res 130:528-534, 2012.
31. Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, et al. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg 214:739-746, 2012.
32. Kassis J, Hirsh J, Podor TJ: Evidence that postoperative fibrinolytic shutdown is mediated by plasma factors that stimulate endothelial cell type I plasminogen activator inhibitor biosynthesis. Blood 80:1758-1764, 1992.
33. Fearnley GR: Fibrinolysis. Ann R Coll Surg Engl 41:51-54, 1967.
34. Hardaway RM, Harke H, Tyroch AH, Williams CH, Vazquez Y, et al. Treatment of severe acute respiratory distress syndrome: a final report on a phase I study. Am Surg 67:377-382, 2001.
35. Valle EJ, Allen CJ, Van Haren RM, Jouria JM, Li H, et al. Do all trauma patients benefit from tranexamic acid? J Trauma Acute Care Surg 76: 1373-1378, 2014.