Fibrinogen and platelet contributions to clot formation: Implications for trauma resuscitation and thromboprophylaxis

Journal of Trauma and Acute Care Surgery

Volumn 76, Issue 2, 2014, Pages 255-263

  Kornblith, Lucy Z ^a   Kutcher, Matthew E ^a   Redick, Brittney J ^a   Calfee, Carolyn S ^a   Vilardi, Ryan F ^a   Cohen, Mitchell Jay ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

clot strength; Functional fibrinogen; thromboprophylaxis.

Indexed keywords

ADULT; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; BLOOD COMPONENT TRANSFUSION; BLOOD PLATELETS; FEMALE; FIBRIN CLOT LYSIS TIME; FIBRINOGEN; HUMANS; INJURY SEVERITY SCORE; LINEAR MODELS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RESUSCITATION; RISK ASSESSMENT; SAMPLING STUDIES; SURVIVAL RATE; THROMBELASTOGRAPHY; THROMBIN TIME; THROMBOSIS; TRAUMA CENTERS; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84894084831     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000108     Document Type: Article

References (28)

1. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55(1):39-44.
2. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54(6):1127-1130.
3. Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012;255(2): 379-385.
4. Cohen MJ,West M. Acute traumatic coagulopathy: from endogenous acute coagulopathy to systemic acquired coagulopathy and back. J Trauma. 2011;70(Suppl 5):S47-S49.
5. Kheirabadi BS, Crissey JM, Deguzman R, Holcomb JB. In vivo bleeding time and in vitro thrombelastography measurements are better indicators of dilutional hypothermic coagulopathy than prothrombin time. J Trauma. 2007;62(6):1352-1359; discussion 1359-1361.
6. Martini WZ, Cortez DS, Dubick MA, Park MS, Holcomb JB. Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs. J Trauma. 2008;65(3): 535-543.
7. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, Pusateri AE,Vos JA, Guymon CH,Wolf SE, et al. Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma. 2009;67(2): 266-275; discussion 275-276.
8. Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma. 2008;64(Suppl 2):S64-S68.
9. Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Khan S, et al. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg. 2012;256(3):476-486.
10. Carroll RC, Craft RM, Langdon RJ, Clanton CR, Snider CC,Wellons DD, Dakin PA, Lawson CM, Enderson BL, Kurek SJ. Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res. 2009;154(1): 34-39.
11. Clauss A. [Rapid physiological coagulation method in determination of fibrinogen [in German]. Acta Haematol. 1957;17(4):237-246.
12. Harr JN, Moore EE, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock. 2013;39(1):45-49.
13. Jeger V,Willi S, Liu T, Yeh DD, De Moya M, Zimmermann H, Exadaktylos AK. The Rapid TEG Angle may be a sensitive predictor of transfusion in moderately injured blunt trauma patients. ScientificWorldJournal. 2012; 2012:821794.
14. Ferguson JJ, Waly HM, Wilson JM. Fundamentals of coagulation and glycoprotein IIb/IIIa receptor inhibition. Am Heart J. 1998;135(4): S35-S42.
15. Mousa SA, Forsythe MS. Comparison of the effect of different platelet GPIIb/IIa antagonists on the dynamics of platelet/fibrin-mediated clot strength induced using thromboelastography. Thromb Res. 2001;104(1): 49-56.
16. Fluger I, Maderova K, Simek M, Hajek R, Zapletalova J, Lonsky V. Comparison of functional fibrinogen assessment using thromboelastography with the standard von Clauss method. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012;156(3):260-261.
17. Kutcher ME, Cripps MW, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Redick BJ, Nelson MF, Cohen MJ. Criteria for empiric treatment of hyperfibrinolysis after trauma. J Trauma Acute Care Surg. 2012;73(1):87-93.
18. Moore FA, Sauaia A, Moore EE, Haenel JB, Burch JM, Lezotte DC. Postinjury multiple organ failure: a bimodal phenomenon. J Trauma. 1996;40(4):501-510; discussion 510-512.
19. Sauaia A, Moore FA, Moore EE, Lezotte DC. Early risk factors for postinjury multiple organ failure. World J Surg. 1996;20(4):392-400.
20. Sauaia A, Moore EE, Johnson JL, Ciesla DJ, Biffl WL, Banerjee A. Validation of postinjury multiple organ failure scores. Shock. 2009;31(5): 438-447.
21. Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Banerjee A, Silliman CC, Sauaia A. Platelets are dominant contributors to hypercoagulability after injury. J Trauma Acute Care Surg. 2013;74(3): 756-762; discussion 762-765.
22. Schochl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, Arndt C, Hanke A, Voelckel W, Solomon C. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care. 2011; 15(2):R83.
23. Schochl H, Cotton B, Inaba K, Nienaber U, Fischer H, Voelckel W, Solomon C. FIBTEM provides early prediction of massive transfusion in trauma. Crit Care. 2011;15(6):R265.
24. Schochl H, Forster L, Woidke R, Solomon C, Voelckel W. Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. Anaesthesia. 2010;65(2):199-203.
25. Schochl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)Yguided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care. 2010;14(2):R55.
26. Schochl H, Posch A, Hanke A, Voelckel W, Solomon C. High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake. Scand J Clin Lab Invest. 2010;70(6):453-457.
27. Kutcher ME, Redick BJ, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Nelson MF, Cohen MJ. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg. 2012;73(1):13-19.
28. Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ,Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg. 2012;214(5):739-746.