Dead-space microdomains hinder extracellular diffusion in rat neocortex during ischemia

Journal of Neuroscience

Volumn 23, Issue 23, 2003, Pages 8351-8359

  Hrabětová, Sabina ^a   Hrabe, Jan ^b   Nicholson, Charles ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Background macromolecules; Diffusion; Dwell time diffusion model; Extracellular space; Ischemia; Tortuosity; Volume fraction

Indexed keywords

DEXTRAN; TETRAMETHYLAMMONIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; DIFFUSION; DIFFUSION COEFFICIENT; EXTRACELLULAR MATRIX; MACROMOLECULE; NEOCORTEX; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; QUANTITATIVE ASSAY; RAT; TISSUE DISTRIBUTION;

EID: 18244420652     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-23-08351.2003     Document Type: Article

References (46)

1. Aschner M, Allen JW, Kimelberg HK, LoPachin RM, Streit WJ (1999) Glial cells in neurotoxicity development. Annu Rev Pharmacol Toxicol 39:151-173.
2. Banay-Schwartz M, Gergely A, Lajtha A (1974) Independence of amino acid uptake from tissue swelling in incubated slices of brain. Brain Res 65:265-276.
3. Basedow AM, Ebert KH (1979) Production, characterization, and solution properties ofdextran tractions of narrow molecular weight distributions. J Polym Sci Pol Sym 66:101-115.
4. Bohrer MP, Patterson GD, Carroll PJ (1984) Hindered diffusion of dextran and Ficoll in microporous membranes. Macromolecules 17:1170-1173.
5. Burton BA, Brant DA (1983) Comparative flexibility extension, and conformation of some simple polysaccharide chains. Biopolymers 22:1769-1792.
6. Einstein A (1956) Investigation on the theory of the Brownian movement. New York: Dover.
7. El-Kareh AW, Braunstein SL,Secomb TW (1993) Effect of cell arrangement and interstitial volume fraction on the diffusivity of monoclonal antibodies in tissue. Biophys J 64:1638-1646.
8. Fellows LK, Boutelle MG, Fillenz M (1992) Extracellular brain glucose levels reflect local neuronal activity - a microdialysis study in awake, freely moving rats. J Neurochem 59:2141-2147.
9. Grosche J, Matyash V, Möller T, Verkhartsky A, Reichenbach A, Kettenmann H (1999) Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells. Nat Neurosci 2:139-143.
10. Hansen AJ, Olsen CE (1980) Brain extracellular space during spreading depression and ischemia. Acta Physiol Scand 108:355-365.
11. Hrabětová S, Nicholson C (2000) Dextran decreases extracellular tortuosity in thick-slice ischemia model. J Cereb Blood Flow Metab 20:1306-1310.
12. Hrabětová S, Chen KC, Masri D, Nicholson C (2002) Water compartmentalization and spread of ischemic injury in thick-slice ischemia model. J Cereb Blood Flow Metab 22:80-88.
13. Kosaka T, Hama K (1986) Three-dimensional structure of astrocytes in the rat dentate gyrus. J Comp Neurol 249:242-260.
14. Križaj D, Rice ME, Wardle RA, Nicholson C (1996) Water compartmentalization and extracellular tortuosity after osmotic changes in cerebellum of Trachemys scripta. J Physiol (Lond) 492:887-896.
15. Kume-Kick J, Mazel T, Voříšek I, Hrabětová S, Tao L, Nicholson C (2002) Independence of extracellular tortuosity and volume fraction during osmotic challenge in rat cortex. J Physiol (Lond) 542:515-527.
16. Leao AAP (1963) On the spread of spreading depression. In: Brain function, Vol 1, Cortical excitability and steady potentials, relations of basic research to space biology (Brazier MAB, ed), pp 73-85. Berkeley, CA: University of California.
17. Lehmenkühler A, Syková E, Svoboda J, Zilles K, Nicholson C (1993) Extracellular space parameters in the rat neocortex and subcortical white matter during postnatal development determined by diffusion analysis. Neuroscience 55:339-351.
18. Mathias RT (1983) Effect of tortuous extracellular pathways on resistance measurements. Biophys J 42:55-59.
19. Molyneux P (1987) Water-soluble synthetic polymers: properties and behavior. Boca Raton, FL: CRC.
20. Newman GC, Hospod FE, Qi H, Patel H (1995) Effects of dextran on hippocampal brain slice water, extracellular space, calcium kinetics and histology. J Neurosci Methods 61:33-46.
21. Nicholson C (1979) Brain cell microenvironment as a communication channel. In: The neurosciences fourth study program (Schmitt FO, Worden FG, eds), pp 457-476. Cambridge, MA: MIT.
22. + uptake. Can J Physiol Pharmacol 70:S314-S322.
23. Nicholson C (1993) Ion-selective microelectrodes and diffusion measurements as tools to explore the brain cell microenvironment. J Neurosci Methods 48:199-213.
24. Nicholson C (2001) Diffusion and related transport mechanisms in brain tissue. Rep Prog Phys 64:815-884.
25. Nicholson C, Phillips JM (1981) Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. J Physiol (Lond) 321:225-257.
26. Nicholson C, Syková E (1998) Extracellular space structure revealed by diffusion analysis. Trends Neurosci 21:207-215.
27. Nicholson C, Tao L (1993) Hindered diffusion of high molecular weight compounds in brain extracellular microenvironment measured with integrative optical imaging. Biophys J 65:2277-2290.
28. Nicholson C, Phillips JM, Tobias C, Kraig RP (1981) Extracellular potassium, calcium and volume profiles during spreading depression. In: Ion-selective microelectrodes and their use in excitable tissues (Syková E, ed), pp 211-223. New York: Plenum.
29. Ogston AG (1958) The spaces in a uniform random suspension of fibers. T Faraday Soc 54:1754-1757.
30. Pappius HM, Elliot AC (1956) Water distribution in incubated slices of brain and other tissues. Can J Biochem Physiol 34:1007-1022.
31. Parsegian VA, Rand RP, Fuller NL, Rau DC (1986) Osmotic stress for the direct measurements of intermolecular spaces. Methods Enzymol 127:400-416.
32. Parsegian VA, Rand RP, Rau DC (1995) Macromolecules and water: probing with osmotic stress. Methods Enzymol 259:43-94.
33. Patlak CS, Hospod FE, Trowbridge SD, Newman GC (1998) Diffusion of radiotracers in normal and ischemic brain slices. J Cereb Blood Flow Metab 18:776-802.
34. Pérez-Pinzón MA,Tao L, Nicholson C (1995) Extracellular potassium, volume fraction, and tortuosity in rat hippocampal CA1, CA3, and cortical slices during ischemia. J Neurophysiol 74:565-573.
35. Prokopová-Kubinová Š, Vargová L, Tao L, Ulbrich K, Šubr V, Syková E, Nicholson C (2001) Poly[N-(2-hydroxypropyl)methacrylamide] polymers diffuse in brain extracellular space with the same tortuosity as small molecules. Biophys J 80:542-548.
36. Rice ME, Nicholson C (1991) Diffusion characteristics and extracellular volume fraction during normoxia and hypoxia in slices of rat neostriatum. J Neurophysiol 65:264-272.
37. Saltzman WM (2001) Drug delivery: engineering principles for drug therapy. New York: Oxford UP.
38. Schultz JS, Valentine R, Choi CY (1979) Reflection coefficients of homopore membranes: effect of molecular size and configuration. J Gen Physiol 73:49-60.
39. Špaček J (1985) Three-dimensional analysis of dendritic spines. Anat Embrayol (Berl) 171:245-252.
40. Syková E, Mazel T, Vargová L, Voříšek I, Prokopová-Kubinová Š (2000) Extracellular space diffusion and pathological states. In: Progress in brain research, Vol 125. Volume transmission revisited (Agnati LF, Fuxe K, Nicholson C, Syková E, eds), pp 155-158. Amsterdam: Elsevier.
41. Tao L (1999) Effects of osmotic stress on dextran diffusion in rat neocortex studied with integrative optical imaging. J Neurophysiol 81:2501-2507.
42. Tao L, Nicholson C (1995) The three-dimensional point spread functions of a microscope objective in image and object space. J Microsc 178:267-271.
43. Tao L, Hrabětová S, Nicholson C (2002) Effect of brain extracellular space geometry on molecular diffusion revealed by Monte Carlo simulation. Soc Neurosci Abstr 28.763.1.
44. Ulbrich K, Pechar M, Strohalm J, Šubr V, Ří hová B (1997) Synthesis of biodegradable polymers for controlled drug release. Ann NY Acad Sci 15:137-141.
45. Van Harreveld A, Malhotra SK (1967) Extracellular space in the cerebral cortex of the mouse. J Anat 101:197-207.
46. +, and pH in the developing rat cortex and corpus callosum. J Cereb Blood Flow Metab 17:191-203.