Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach

Biomaterials

Volumn 76, Issue , 2016, Pages 157-172

  Bersini, Simone ^a   Gilardi, Mara ^a,b   Arrigoni, Chiara ^c   Talò, Giuseppe ^c   Zamai, Moreno ^d   Zagra, Luigi ^a   Caiolfa, Valeria ^d   Moretti, Matteo ^a  

^a IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c IRCCS POLICLINICO SAN DONATO   (Italy)

^d CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

Bone mimicking; Computational simulation; Design of experiment; ECM remodeling; Microvascular networks; Oxygen distribution

Indexed keywords

BLOOD VESSELS; BONE; CELL CULTURE; CELL ENGINEERING; CELLS; COMPLEX NETWORKS; COMPUTATIONAL GEOMETRY; CYTOLOGY; DESIGN OF EXPERIMENTS; ENDOTHELIAL CELLS; FLOWCHARTING; HISTOLOGY; HYDROGELS; OXYGEN; PHYSIOLOGICAL MODELS; STEM CELLS; THROUGHPUT; TISSUE;

COMPUTATIONAL SIMULATION; EXPERIMENTAL APPROACHES; EXPERIMENTAL CONDITIONS; HIGH THROUGHPUT SCREENING; HIGH-THROUGHPUT SCREENS; MICROVASCULAR NETWORK; OXYGEN DISTRIBUTION; TISSUE ENGINEERING APPLICATIONS;

TISSUE ENGINEERING;

OSTEOCALCIN; OSTEONECTIN; OSTEOPONTIN;

ANGIOGENESIS; ARTICLE; BONE DEVELOPMENT; BONE TISSUE; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL SURVIVAL; COCULTURE; ENDOTHELIUM; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HYDROGEL; IN VITRO STUDY; MESENCHYMAL STEM CELL; MICROENVIRONMENT; MICROFLUIDICS; OXYGEN CONCENTRATION; OXYGEN CONSUMPTION; OXYGEN DIFFUSION; PRIORITY JOURNAL; TISSUE ENGINEERING; BONE; COMPUTER SIMULATION; HUMAN; VASCULARIZATION;

BONE AND BONES; COCULTURE TECHNIQUES; COMPUTER SIMULATION; EXTRACELLULAR MATRIX; HUMANS; IN VITRO TECHNIQUES; TISSUE ENGINEERING;

EID: 84961209157     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.10.057     Document Type: Article

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