Three-dimensional cell aggregates composed of HUVECs and cbMSCs for therapeutic neovascularization in a mouse model of hindlimb ischemia

Biomaterials

Volumn 34, Issue 8, 2013, Pages 1995-2004

  Chen, Ding Yuan ^a   Wei, Hao Ji ^b,c   Lin, Kun Ju ^d,e   Huang, Chieh Cheng ^a   Wang, Chung Chi ^b,c   Wu, Cheng Tse ^a   Chao, Ko Ting ^e   Chen, Ko Jie ^a   Chang, Yen ^b,c   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Cell based therapy; Critical limb ischemia; Neovascularization; Thermo responsive hydrogel; Tissue engineering

Indexed keywords

ADHESION MOLECULES; BLOOD PERFUSION; CELL AGGREGATES; CELL FUNCTIONS; CELL-BASED; CELL-BASED THERAPY; CELL-CELL COMMUNICATIONS; CELL-CELL CONTACT; CRITICAL LIMB ISCHEMIA; EXTRACELLULAR MATRICES; HIND LIMBS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IMMUNOSTAINING; ISCHEMIC LIMBS; MESENCHYMAL STEM CELL; MOUSE MODELS; MYOCARDIN; NEOVASCULARIZATION; REAL-TIME PCR; SMOOTH MUSCLE CELLS; THERAPEUTIC STRATEGY; THERMO-RESPONSIVE; TUBULAR NETWORKS; TUBULAR STRUCTURES; VESSEL FORMATION;

BLOOD; CELL CULTURE; ENDOTHELIAL CELLS; MAMMALS; POLYMERASE CHAIN REACTION; SIGNALING; THREE DIMENSIONAL; THREE DIMENSIONAL COMPUTER GRAPHICS; TISSUE; TISSUE ENGINEERING;

AGGREGATES;

MATRIGEL; MYOCARDIN; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORD BLOOD MESENCHYMAL STEM CELL; CRITICAL LIMB ISCHEMIA; HINDLIMB; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL AGGREGATION; COLLAGEN; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; FETAL BLOOD; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HINDLIMB; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ISCHEMIA; LAMININ; LIMB SALVAGE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; METHYLCELLULOSE; MICE; MICE, INBRED BALB C; NEOVASCULARIZATION, PHYSIOLOGIC; PERFUSION; PROTEOGLYCANS;

EID: 84871529171     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.11.045     Document Type: Article

References (42)

1. Segers V.F., Revin V., Wu W., Qiu H., Yan Z., Lee R.T., et al. Protease-resistant stromal cell-derived factor-1 for the treatment of experimental peripheral artery disease. Circulation 2011, 123:1306-1315.
2. Rey S., Lee K., Wang C.J., Gupta K., Chen S., McMillan A., et al. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci USA 2009, 106:20399-20404.
3. Yang H.N., Park J.S., Woo D.G., Jeon S.Y., Park K.H. Transfection of VEGF(165) genes into endothelial progenitor cells and in vivo imaging using quantum dots in an ischemia hind limb model. Biomaterials 2012, 33:8670-8684.
4. Urao N., Inomata H., Razvi M., Kim H.W., Wary K., McKinney R., et al. Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia. Circ Res 2008, 103:212-220.
5. Melero-Martin J.M., Khan Z.A., Picard A., Wu X., Paruchuri S., Bischoff J. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood 2007, 109:4761-4768.
6. Jain R.K., Au P., Tam J., Duda D.G., Fukumura D. Engineering vascularized tissue. Nat Biotechnol 2005, 23:821-823.
7. Au P., Tam J., Duda D.G., Lin P.C., Munn L.L., Fukumura D., et al. Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. Am J Pathol 2009, 175:294-302.
8. Trkov S., Eng G., Di Liddo R., Parnigotto P.P., Vunjak-Novakovic G. Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions. J Tissue Eng Regen Med 2010, 4:205-215.
9. Armulik A., Abramsson A., Betsholtz C. Endothelial/pericyte interactions. Circ Res 2005, 97:512-523.
10. Regan J.N., Majesky M.W. Building a vessel wall with notch signaling. Circ Res 2009, 104:419-421.
11. Lee J., Cuddihy M.J., Kotov N.A. Three-dimensional cell culture matrices: state of the art. Tissue Eng Part B Rev 2008, 14:61-86.
12. Davis G.E., Senger D.R. Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res 2005, 97:1093-1107.
13. Abbott A. Cell culture: biology's new dimension. Nature 2003, 424:870-872.
14. Steinberg M.S. " ECM" : its nature, origin and function in cell aggregation. Exp Cell Res 1963, 30:257-279.
15. Derda R., Laromaine A., Mammoto A., Tang S.K., Mammoto T., Ingber D.E., et al. Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A 2009, 106:18457-18462.
16. Bhang S.H., Cho S.W., La W.G., Lee T.J., Yang H.S., Sun A.Y., et al. Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells. Biomaterials 2011, 32:2734-2747.
17. Lee W.Y., Chang Y.H., Yeh Y.C., Chen C.H., Lin K.M., Huang C.C., et al. The use of injectable spherically symmetric cell aggregates self-assembled in a thermo-responsive hydrogel for enhanced cell transplantation. Biomaterials 2009, 30:5505-5513.
18. Lee W.Y., Wei H.J., Lin W.W., Yeh Y.C., Hwang S.M., Wang J.J., et al. Enhancement of cell retention and functional benefits in myocardial infarction using human amniotic-fluid stem-cell bodies enriched with endogenous ECM. Biomaterials 2011, 32:5558-5567.
19. Lee W.Y., Tsai H.W., Chiang J.H., Hwang S.M., Chen D.Y., Hsu L.W., et al. Core-shell cell bodies composed of human cbMSCs and HUVECs for functional vasculogenesis. Biomaterials 2011, 32:8446-8455.
20. Hung C.J., Yao C.L., Cheng F.C., Wu M.L., Wang T.H., Hwang S.M. Establishment of immortalized mesenchymal stromal cells with red fluorescence protein expression for in vivo transplantation and tracing in the rat model with traumatic brain injury. Cytotherapy 2010, 12:455-465.
21. Pirotte S., Lamour V., Lambert V., Alvarez Gonzalez M.L., Ormenese S., Noel A., et al. Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood 2011, 117:2515-2526.
22. Rehman J., Traktuev D., Li J., Merfeld-Clauss S., Temm-Grove C.J., Bovenkerk J.E., et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004, 109:1292-1298.
23. Layman H., Spiga M.G., Brooks T., Pham S., Webster K.A., Andreopoulos F.M. The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model. Biomaterials 2007, 28:2646-2654.
24. Miranville A., Heeschen C., Sengenes C., Curat C.A., Busse R., Bouloumie A. Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation 2004, 110:349-355.
25. Yeh Y.C., Wei H.J., Lee W.Y., Yu C.L., Chang Y., Hsu L.W., et al. Cellular cardiomyoplasty with human amniotic fluid stem cells: in vitro and in vivo studies. Tissue Eng Part A 2010, 16:1925-1936.
26. Yamada K.M., Cukierman E. Modeling tissue morphogenesis and cancer in 3D. Cell 2007, 130:601-610.
27. Chen C.H., Chang Y., Wang C.C., Huang C.H., Huang C.C., Yeh Y.C., et al. Construction and characterization of fragmented mesenchymal-stem-cell sheets for intramuscular injection. Biomaterials 2007, 28:4643-4651.
28. Yang M.J., Chen C.H., Lin P.J., Huang C.H., Chen W., Sung H.W. Novel method of forming human embryoid bodies in a polystyrene dish surface-coated with a temperature-responsive methylcellulose hydrogel. Biomacromolecules 2007, 8:2746-2752.
29. Potapova I.A., Gaudette G.R., Brink P.R., Robinson R.B., Rosen M.R., Cohen I.S., et al. Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro. Stem Cells 2007, 25:1761-1768.
30. Grant D.S., Lelkes P.I., Fukuda K., Kleinman H.K. Intracellular mechanisms involved in basement membrane induced blood vessel differentiation in vitro. In Vitro Cell Dev Biol 1991, 27A:327-336.
31. Tibbitt M.W., Anseth K.S. Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol Bioeng 2009, 103:655-663.
32. Pampaloni F., Reynaud E.G., Stelzer E.H. The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 2007, 8:839-845.
33. Sun G., Shen Y.I., Kusuma S., Fox-Talbot K., Steenbergen C.J., Gerecht S. Functional neovascularization of biodegradable dextran hydrogels with multiple angiogenic growth factors. Biomaterials 2011, 32:95-106.
34. Williams C., Xie A.W., Emani S., Yamato M., Okano T., Emani S.M., et al. A comparison of human smooth muscle and mesenchymal stem cells as potential cell sources for tissue-engineered vascular patches. Tissue Eng Part A 2012, 18:986-998.
35. Delafontaine P., Song Y.H., Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 2004, 24:435-444.
36. Gnecchi M., Zhang Z., Ni A., Dzau V.J. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008, 103:1204-1219.
37. Chimenti I., Smith R.R., Li T.S., Gerstenblith G., Messina E., Giacomello A., et al. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res 2010, 106:971-980.
38. Bhang S.H., Lee S., Lee T.J., La W.G., Yang H.S., Cho S.W., et al. Three-dimensional cell grafting enhances the angiogenic efficacy of human umbilical vein endothelial cells. Tissue Eng Part A 2012, 18:310-319.
39. Kurpinski K., Lam H., Chu J., Wang A., Kim A., Tsay E., et al. Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. Stem Cells 2010, 28:734-742.
40. Massague J., Chen Y.G. Controlling TGF-beta signaling. Genes Dev 2000, 14:627-644.
41. Ventura C. Forced myocardin expression primes cardiac and smooth muscle transcription patterning in human mesenchymal stem cells. Cardiovasc Res 2005, 67:182-183.
42. Au P., Tam J., Fukumura D., Jain R.K. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood 2008, 111:4551-4558.