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Volumn 10, Issue 7, 2016, Pages 924-934

NMR-based metabolomics to determine acute inhalation effects of nano- and fine-sized ZnO particles in the rat lung

Author keywords

Fine particles; metabolomics; nano particles; respiratory toxicity; zinc oxide

Indexed keywords

ACETIC ACID; ASCORBIC ACID; FORMIC ACID; GLUCOSE; GLYCEROPHOSPHORYLCHOLINE; GLYCINE; ISOLEUCINE; PHOSPHORYLCHOLINE; TAURINE; TRIMETHYLAMINE OXIDE; VALINE; ZINC OXIDE; NANOPARTICLE;

EID: 84961208436     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2016.1144825     Document Type: Article
Times cited : (37)

References (57)
  • 1
    • 0025742873 scopus 로고
    • Ozone-induced lipid peroxidation and membrane leakage in isolated rat alveolar macrophages: protective effects of taurine
    • M.A.Banks, D.W.Porter, W.G.Martin, V.Castranova 1991. Ozone-induced lipid peroxidation and membrane leakage in isolated rat alveolar macrophages: protective effects of taurine. J Nutr Biochem 2:308–13.
    • (1991) J Nutr Biochem , vol.2 , pp. 308-313
    • Banks, M.A.1    Porter, D.W.2    Martin, W.G.3    Castranova, V.4
  • 3
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Y.Benjamini, Y.Hochberg 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B 57:289–300.
    • (1995) J R Stat Soc Series B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 4
    • 65049090071 scopus 로고    scopus 로고
    • Environmental toxicity, redox signaling and lung inflammation: the role of glutathione
    • S.K.Biswas, I.Rahman 2009. Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med 30:60–76.
    • (2009) Mol Aspects Med , vol.30 , pp. 60-76
    • Biswas, S.K.1    Rahman, I.2
  • 5
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • E.G.Bligh, W.J.Dyer 1959. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911–17.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 6
    • 77949399860 scopus 로고    scopus 로고
    • NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration
    • Q.Bu, G.Yan, P.Deng, F.Peng, H.Lin, Y.Xu, et al. 2010. NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnology 21:125105.
    • (2010) Nanotechnology , vol.21
    • Bu, Q.1    Yan, G.2    Deng, P.3    Peng, F.4    Lin, H.5    Xu, Y.6
  • 8
    • 0036016864 scopus 로고    scopus 로고
    • Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model
    • F.R.Cassee, H.Muijser, E.Duistermaat, J.J.Freijer, K.B.Geerse, J.C.Marijnissen, et al. 2002. Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model. Arch Toxicol 76:277–86.
    • (2002) Arch Toxicol , vol.76 , pp. 277-286
    • Cassee, F.R.1    Muijser, H.2    Duistermaat, E.3    Freijer, J.J.4    Geerse, K.B.5    Marijnissen, J.C.6
  • 9
    • 84855878885 scopus 로고    scopus 로고
    • Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
    • W.S.Cho, R.Duffin, C.A.Poland, A.Duschl, G.J.Oostingh, W.Macnee, et al. 2012. Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs. Nanotoxicology 6:22–35.
    • (2012) Nanotoxicology , vol.6 , pp. 22-35
    • Cho, W.S.1    Duffin, R.2    Poland, C.A.3    Duschl, A.4    Oostingh, G.J.5    Macnee, W.6
  • 10
    • 78650269106 scopus 로고    scopus 로고
    • Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing
    • W.S.Cho, R.Duffin, C.A.Poland, S.E.Howie, W.Macnee, M.Bradley, et al. 2010. Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect 118:1699–706.
    • (2010) Environ Health Perspect , vol.118 , pp. 1699-1706
    • Cho, W.S.1    Duffin, R.2    Poland, C.A.3    Howie, S.E.4    Macnee, W.5    Bradley, M.6
  • 11
    • 1642504765 scopus 로고    scopus 로고
    • Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment
    • R.B.Conolly, W.K.Lutz 2004. Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment. Toxicol Sci 77:151–7.
    • (2004) Toxicol Sci , vol.77 , pp. 151-157
    • Conolly, R.B.1    Lutz, W.K.2
  • 12
    • 80052537544 scopus 로고    scopus 로고
    • Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury
    • J.P.Fabisiak, M.Medvedovic, D.C.Alexander, J.E.Mcdunn, V.J.Concel, K.Bein, et al. 2011. Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury. Mol Nutr Food Res 55:1423–34.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1423-1434
    • Fabisiak, J.P.1    Medvedovic, M.2    Alexander, D.C.3    Mcdunn, J.E.4    Concel, V.J.5    Bein, K.6
  • 13
    • 0030848962 scopus 로고    scopus 로고
    • Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value
    • J.M.Fine, T.Gordon, L.C.Chen, P.Kinney, G.Falcone, W.S.Beckett 1997. Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. J Occup Environ Med 39:722–6.
    • (1997) J Occup Environ Med , vol.39 , pp. 722-726
    • Fine, J.M.1    Gordon, T.2    Chen, L.C.3    Kinney, P.4    Falcone, G.5    Beckett, W.S.6
  • 14
    • 34147158989 scopus 로고    scopus 로고
    • Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition
    • A.Gojova, B.Guo, R.S.Kota, J.C.Rutledge, I.M.Kennedy, A.I.Barakat 2007. Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ Health Perspect 115:403–9.
    • (2007) Environ Health Perspect , vol.115 , pp. 403-409
    • Gojova, A.1    Guo, B.2    Kota, R.S.3    Rutledge, J.C.4    Kennedy, I.M.5    Barakat, A.I.6
  • 15
    • 0027622211 scopus 로고
    • Metal fume fever
    • T.Gordon, J.M.Fine 1993. Metal fume fever. Occup Med 8:505–17.
    • (1993) Occup Med , vol.8 , pp. 505-517
    • Gordon, T.1    Fine, J.M.2
  • 16
    • 33750431077 scopus 로고    scopus 로고
    • Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders
    • J.L.Griffin, A.W.Nicholls 2006. Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders. Pharmacogenomics 7:1095–107.
    • (2006) Pharmacogenomics , vol.7 , pp. 1095-1107
    • Griffin, J.L.1    Nicholls, A.W.2
  • 17
    • 84925077549 scopus 로고    scopus 로고
    • Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing. – relationships genotoxicity
    • M.Guérard, M.Baum, A.Bitsch, G.Eisenbrand, A.Elhajouji, B.Epe, et al. 2015. Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing. – relationships genotoxicity. Mutat Res Rev Mutat Res 763:181–201.
    • (2015) Mutat Res Rev Mutat Res , vol.763 , pp. 181-201
    • Guérard, M.1    Baum, M.2    Bitsch, A.3    Eisenbrand, G.4    Elhajouji, A.5    Epe, B.6
  • 18
    • 0034751903 scopus 로고    scopus 로고
    • Antioxidant effect of taurine against lead-induced oxidative stress
    • H.Gurer, H.Ozgunes, E.Saygin, N.Ercal 2001. Antioxidant effect of taurine against lead-induced oxidative stress. Arch Environ Contam Toxicol 41:397–402.
    • (2001) Arch Environ Contam Toxicol , vol.41 , pp. 397-402
    • Gurer, H.1    Ozgunes, H.2    Saygin, E.3    Ercal, N.4
  • 19
    • 82755162606 scopus 로고    scopus 로고
    • Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: mass and surface area as an exposure metric
    • M.Ho, K.Y.Wu, H.M.Chein, L.C.Chen, T.J.Cheng 2011. Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: mass and surface area as an exposure metric. Inhal Toxicol 23:947–56.
    • (2011) Inhal Toxicol , vol.23 , pp. 947-956
    • Ho, M.1    Wu, K.Y.2    Chein, H.M.3    Chen, L.C.4    Cheng, T.J.5
  • 20
    • 84911808036 scopus 로고    scopus 로고
    • Characterization of the biochemical effects of naphthalene on the mouse respiratory system using NMR-based metabolomics
    • J.H.Hong, W.C.Lee, Y.M.Hsu, H.J.Liang, C.H.Wan, C.L.Chien, et al. 2014. Characterization of the biochemical effects of naphthalene on the mouse respiratory system using NMR-based metabolomics. J Appl Toxicol 34:1379–88.
    • (2014) J Appl Toxicol , vol.34 , pp. 1379-1388
    • Hong, J.H.1    Lee, W.C.2    Hsu, Y.M.3    Liang, H.J.4    Wan, C.H.5    Chien, C.L.6
  • 21
    • 45849133740 scopus 로고    scopus 로고
    • Metabolomics in lung inflammation:a high-resolution (1)h NMR study of mice exposedto silica dust
    • J.Z.Hu, D.N.Rommereim, K.R.Minard, A.Woodstock, B.J.Harrer, R.A.Wind, et al. 2008. Metabolomics in lung inflammation:a high-resolution (1)h NMR study of mice exposedto silica dust. Toxicol Mech Methods 18:385–98.
    • (2008) Toxicol Mech Methods , vol.18 , pp. 385-398
    • Hu, J.Z.1    Rommereim, D.N.2    Minard, K.R.3    Woodstock, A.4    Harrer, B.J.5    Wind, R.A.6
  • 23
    • 79951605047 scopus 로고    scopus 로고
    • Comparative pulmonary toxicity of inhaled nickel nanoparticles; role of deposited dose and solubility
    • G.S.Kang, P.A.Gillespie, A.Gunnison, H.Rengifo, J.Koberstein, L.C.Chen 2011. Comparative pulmonary toxicity of inhaled nickel nanoparticles; role of deposited dose and solubility. Inhal Toxicol 23:95–103.
    • (2011) Inhal Toxicol , vol.23 , pp. 95-103
    • Kang, G.S.1    Gillespie, P.A.2    Gunnison, A.3    Rengifo, H.4    Koberstein, J.5    Chen, L.C.6
  • 24
    • 0031260302 scopus 로고    scopus 로고
    • Early pulmonary cytokine responses to zinc oxide fume inhalation
    • W.G.Kuschner, A.Dalessandro, H.F.Wong, P.D.Blanc 1997. Early pulmonary cytokine responses to zinc oxide fume inhalation. Environ Res 75:7–11.
    • (1997) Environ Res , vol.75 , pp. 7-11
    • Kuschner, W.G.1    Dalessandro, A.2    Wong, H.F.3    Blanc, P.D.4
  • 25
    • 52049096592 scopus 로고    scopus 로고
    • Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity
    • R.Lei, C.Wu, B.Yang, H.Ma, C.Shi, Q.Wang, et al. 2008. Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity. Toxicol Appl Pharmacol 232:292–301.
    • (2008) Toxicol Appl Pharmacol , vol.232 , pp. 292-301
    • Lei, R.1    Wu, C.2    Yang, B.3    Ma, H.4    Shi, C.5    Wang, Q.6
  • 26
    • 33747815789 scopus 로고    scopus 로고
    • Metabolomics: methodologies and applications in the environmental sciences
    • C.Y.Lin, M.R.Viant, R.S.Tjeerdema 2006. Metabolomics: methodologies and applications in the environmental sciences. J Pestic Sci 31:245–51.
    • (2006) J Pestic Sci , vol.31 , pp. 245-251
    • Lin, C.Y.1    Viant, M.R.2    Tjeerdema, R.S.3
  • 27
    • 33947427846 scopus 로고    scopus 로고
    • Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics
    • C.Y.Lin, H.Wu, R.Tjeerdema, M.Viant 2007. Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics 3:55–67.
    • (2007) Metabolomics , vol.3 , pp. 55-67
    • Lin, C.Y.1    Wu, H.2    Tjeerdema, R.3    Viant, M.4
  • 28
    • 71549155943 scopus 로고    scopus 로고
    • Characterization of the metabolic actions of crude versus dispersed oil in salmon smolts via NMR-based metabolomics
    • C.Y.Lin, B.S.Anderson, B.M.Phillips, A.C.Peng, S.Clark, J.Voorhees, et al. 2009a. Characterization of the metabolic actions of crude versus dispersed oil in salmon smolts via NMR-based metabolomics. Aquat Toxicol 95:230–8.
    • (2009) Aquat Toxicol , vol.95 , pp. 230-238
    • Lin, C.Y.1    Anderson, B.S.2    Phillips, B.M.3    Peng, A.C.4    Clark, S.5    Voorhees, J.6
  • 29
    • 67349202746 scopus 로고    scopus 로고
    • 1H NMR to investigate metabolism and energy supply in rhesus macaque sperm
    • C.Y.Lin, P.H.Hung, C.A.Vandevoort, M.G.Miller 2009b. 1H NMR to investigate metabolism and energy supply in rhesus macaque sperm. Reprod Toxicol 28:75–80.
    • (2009) Reprod Toxicol , vol.28 , pp. 75-80
    • Lin, C.Y.1    Hung, P.H.2    Vandevoort, C.A.3    Miller, M.G.4
  • 30
    • 58149185440 scopus 로고    scopus 로고
    • Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells
    • W.S.Lin, Y.Xu, C.C.Huang, Y.F.Ma, K.B.Shannon, D.R.Chen, et al. 2009c. Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells. J Nanopart Res 11:25–39.
    • (2009) J Nanopart Res , vol.11 , pp. 25-39
    • Lin, W.S.1    Xu, Y.2    Huang, C.C.3    Ma, Y.F.4    Shannon, K.B.5    Chen, D.R.6
  • 31
    • 70049118476 scopus 로고    scopus 로고
    • A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pattern recognition
    • Z.Y.Lin, P.B.Xu, S.K.Yan, H.B.Meng, G.J.Yang, W.X.Dai, et al. 2009d. A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pattern recognition. NMR Biomed 22:601–8.
    • (2009) NMR Biomed , vol.22 , pp. 601-608
    • Lin, Z.Y.1    Xu, P.B.2    Yan, S.K.3    Meng, H.B.4    Yang, G.J.5    Dai, W.X.6
  • 32
    • 73349091531 scopus 로고    scopus 로고
    • Two-dimensional J-resolved NMR spectroscopy: review of a key methodology in the metabolomics toolbox
    • C.Ludwig, M.R.Viant 2010. Two-dimensional J-resolved NMR spectroscopy: review of a key methodology in the metabolomics toolbox. Phytochem Anal 21:22–32.
    • (2010) Phytochem Anal , vol.21 , pp. 22-32
    • Ludwig, C.1    Viant, M.R.2
  • 33
    • 0028263767 scopus 로고
    • Glutathione-ascorbic acid antioxidant system in animals
    • A.Meister 1994. Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem 269:9397–400.
    • (1994) J Biol Chem , vol.269 , pp. 9397-9400
    • Meister, A.1
  • 35
    • 33845214358 scopus 로고    scopus 로고
    • Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy
    • G.Oberdorster, A.Maynard, K.Donaldson, V.Castranova, J.Fitzpatrick, K.Ausman, et al. 2005. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2:8.
    • (2005) Part Fibre Toxicol , vol.2 , pp. 8
    • Oberdorster, G.1    Maynard, A.2    Donaldson, K.3    Castranova, V.4    Fitzpatrick, J.5    Ausman, K.6
  • 36
    • 33745434064 scopus 로고    scopus 로고
    • Diagnosing inborn errors of lipid metabolism with proton nuclear magnetic resonance spectroscopy
    • M.Oostendorp, U.F.H.Engelke, M.P.Willemsen, R.A.Wevers 2006. Diagnosing inborn errors of lipid metabolism with proton nuclear magnetic resonance spectroscopy. Clin Chem 52:1395–405.
    • (2006) Clin Chem , vol.52 , pp. 1395-1405
    • Oostendorp, M.1    Engelke, U.F.H.2    Willemsen, M.P.3    Wevers, R.A.4
  • 37
    • 81555223869 scopus 로고    scopus 로고
    • ¹H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus
    • X.Ouyang, Y.Dai, J.L.Wen, L.X.Wang 2011. ¹H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus. Lupus 20:1411–20.
    • (2011) Lupus , vol.20 , pp. 1411-1420
    • Ouyang, X.1    Dai, Y.2    Wen, J.L.3    Wang, L.X.4
  • 38
    • 0041845178 scopus 로고    scopus 로고
    • Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences
    • R.Plumb, J.Granger, C.Stumpf, I.D.Wilson, J.A.Evans, E.M.Lenz 2003. Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences. Analyst 128:819–23.
    • (2003) Analyst , vol.128 , pp. 819-823
    • Plumb, R.1    Granger, J.2    Stumpf, C.3    Wilson, I.D.4    Evans, J.A.5    Lenz, E.M.6
  • 40
    • 0027327373 scopus 로고
    • Biology of free radical scavengers: an evaluation of ascorbate
    • R.C.Rose, A.M.Bode 1993. Biology of free radical scavengers: an evaluation of ascorbate. FASEB J 7:1135–42.
    • (1993) FASEB J , vol.7 , pp. 1135-1142
    • Rose, R.C.1    Bode, A.M.2
  • 41
    • 34347234840 scopus 로고    scopus 로고
    • Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    • C.M.Sayes, K.L.Reed, D.B.Warheit 2007. Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci 97:163–80.
    • (2007) Toxicol Sci , vol.97 , pp. 163-180
    • Sayes, C.M.1    Reed, K.L.2    Warheit, D.B.3
  • 43
    • 0642285743 scopus 로고    scopus 로고
    • Taurine: new implications for an old amino acid
    • G.B.Schuller-Levis, E.Park 2003. Taurine: new implications for an old amino acid. FEMS Microbiol Lett 226:195–202.
    • (2003) FEMS Microbiol Lett , vol.226 , pp. 195-202
    • Schuller-Levis, G.B.1    Park, E.2
  • 44
    • 49049103814 scopus 로고    scopus 로고
    • Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury
    • N.J.Serkova, Z.Van Rheen, M.Tobias, J.E.Pitzer, J.E.Wilkinson, K.A.Stringer 2008. Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol 295:L152–61.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , pp. L152-L161
    • Serkova, N.J.1    Van Rheen, Z.2    Tobias, M.3    Pitzer, J.E.4    Wilkinson, J.E.5    Stringer, K.A.6
  • 47
    • 0141757204 scopus 로고    scopus 로고
    • Improved methods for the acquisition and interpretation of NMR metabolomic data
    • M.R.Viant 2003. Improved methods for the acquisition and interpretation of NMR metabolomic data. Biochem Biophys Res Commun 310:943–8.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 943-948
    • Viant, M.R.1
  • 48
    • 56849132315 scopus 로고    scopus 로고
    • Splendid one-dimensional nanostructures of zinc oxide: a new nanomaterial family for nanotechnology
    • Z.L.Wang 2008. Splendid one-dimensional nanostructures of zinc oxide: a new nanomaterial family for nanotechnology. ACS Nano 2:1987–92.
    • (2008) ACS Nano , vol.2 , pp. 1987-1992
    • Wang, Z.L.1
  • 49
    • 70449858799 scopus 로고    scopus 로고
    • Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures?
    • D.B.Warheit, C.M.Sayes, K.L.Reed 2009. Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures? Environ Sci Technol 43:7939–45.
    • (2009) Environ Sci Technol , vol.43 , pp. 7939-7945
    • Warheit, D.B.1    Sayes, C.M.2    Reed, K.L.3
  • 50
    • 78649980497 scopus 로고    scopus 로고
    • Lipidomics: new tools and applications
    • M.R.Wenk 2010. Lipidomics: new tools and applications. Cell 143:888–95.
    • (2010) Cell , vol.143 , pp. 888-895
    • Wenk, M.R.1
  • 52
    • 77954847556 scopus 로고    scopus 로고
    • Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells
    • W.Wu, J.M.Samet, D.B.Peden, P.A.Bromberg 2010. Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells. Environ Health Perspect 118:982–7.
    • (2010) Environ Health Perspect , vol.118 , pp. 982-987
    • Wu, W.1    Samet, J.M.2    Peden, D.B.3    Bromberg, P.A.4
  • 53
    • 56049106549 scopus 로고    scopus 로고
    • Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties
    • T.Xia, M.Kovochich, M.Liong, L.Maedler, B.Gilbert, H.Shi, et al. 2008. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2:2121–34.
    • (2008) ACS Nano , vol.2 , pp. 2121-2134
    • Xia, T.1    Kovochich, M.2    Liong, M.3    Maedler, L.4    Gilbert, B.5    Shi, H.6
  • 55
    • 77953695390 scopus 로고    scopus 로고
    • Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis
    • G.Zhai, R.Wang-Sattler, D.J.Hart, N.K.Arden, A.J.Hakim, T.Illig, et al. 2010. Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis 69:1227–31.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1227-1231
    • Zhai, G.1    Wang-Sattler, R.2    Hart, D.J.3    Arden, N.K.4    Hakim, A.J.5    Illig, T.6
  • 56
    • 52049118795 scopus 로고    scopus 로고
    • Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats
    • S.C.Zhang, G.N.Gowda, V.Asiago, N.Shanaiah, C.Barbas, D.Raftery 2008. Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats. Anal Biochem 383:76–84.
    • (2008) Anal Biochem , vol.383 , pp. 76-84
    • Zhang, S.C.1    Gowda, G.N.2    Asiago, V.3    Shanaiah, N.4    Barbas, C.5    Raftery, D.6
  • 57
    • 61849159858 scopus 로고    scopus 로고
    • Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons
    • J.Zhao, L.Xu, T.Zhang, G.Ren, Z.Yang 2009. Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons. Neurotoxicology 30:220–30.
    • (2009) Neurotoxicology , vol.30 , pp. 220-230
    • Zhao, J.1    Xu, L.2    Zhang, T.3    Ren, G.4    Yang, Z.5


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