Potential Therapeutic Aspects of Alarmin Cytokine Interleukin 33 or Its Inhibitors in Various Diseases

Clinical Therapeutics

Volumn 38, Issue 5, 2016, Pages 1000-1016.e1

  Arshad, Muhammad Imran ^a,b,c,d   Khan, Hilal Ahmad ^d   Noel, Gregory ^a,b,c   Piquet Pellorce, Claire ^a,b,c   Samson, Michel ^a,b,c  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c UNIVERSITÉ DE RENNES 1   (France)

^d UNIVERSITY OF AGRICULTURE   (Pakistan)

Author keywords

IL 33; immunity; Key words diseases; therapeutic aspects

Indexed keywords

ALARMIN; IMMUNOGLOBULIN E; INTERLEUKIN 33;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; CD8+ T LYMPHOCYTE; DISEASE EXACERBATION; DRUG ACTIVITY; DRUG MECHANISM; GAMMA DELTA T LYMPHOCYTE; HUMAN; IMMUNE RESPONSE; INFECTION; MACROPHAGE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; TRANSCRIPTION REGULATION; ANIMAL; IMMUNOLOGY; LEUKOCYTE; MEDICAL RESEARCH; MOUSE; PHYSIOLOGY;

ALARMINS; ANIMALS; BIOMEDICAL RESEARCH; HUMANS; INTERLEUKIN-33; LEUKOCYTES; MICE;

EID: 84961166716     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2016.02.021     Document Type: Review

References (85)

1. J.J. Oppenheim, and D. Yang Alarmins: chemotactic activators of immune responses Curr Opin Immunol 17 2005 359 365
2. J. Schmitz, A. Owyang, E. Oldham, and et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines Immunity 23 2005 479 490
3. M.E. Bianchi DAMPs, PAMPs and alarmins: all we need to know about danger J Leukoc Biol 81 2007 1 5
4. H. Onda, H. Kasuya, K. Takakura, and et al. Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage J Cereb Blood Flow Metab 19 1999 1279 1288
5. E.S. Baekkevold, M. Roussigne, T. Yamanaka, and et al. Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules Am J Pathol 163 2003 69 79
6. C. Moussion, N. Ortega, and J.P. Girard The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One 3 2008 e3331
7. M.I. Arshad, M. Rauch, A. L'Helgoualc'h, and et al. NKT cells are required to induce high IL-33 expression in hepatocytes during ConA-induced acute hepatitis Eur J Immunol 41 2011 2341 2348
8. P. Marvie, M. Lisbonne, A. L'Helgoualc'h, and et al. Interleukin-33 overexpression is associated with liver fibrosis in mice and humans J Cell Mol Med 14 2010 1726 1739
9. G.E. Murphy, D. Xu, F.Y. Liew, and I.B. McInnes Role of interleukin 33 in human immunopathology Ann Rheum Dis 69 Suppl 1 2010 i43 i47
10. M.I. Arshad, P. Guihard, Y. Danger, and et al. Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2+CD4+ lymphocytes Am J Physiol Gastrointest Liver Physiol 309 2015 G542 G553
11. J.L. Barlow, A. Bellosi, C.S. Hardman, and et al. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity J Allergy Clin Immunol 129 191-198 2012 e191 e194
12. A.G. Besnard, D. Togbe, N. Guillou, and et al. IL-33-activated dendritic cells are critical for allergic airway inflammation Eur J Immunol 41 2011 1675 1686
13. M. Komai-Koma, D.S. Gilchrist, A.N. McKenzie, and et al. IL-33 activates B1 cells and exacerbates contact sensitivity J Immunol 186 2011 2584 2591
14. M.D. Smithgall, M.R. Comeau, B.R. Yoon, and et al. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells Int Immunol 20 2008 1019 1030
15. R. Saluja, M. Khan, M.K. Church, and M. Maurer The role of IL-33 and mast cells in allergy and inflammation Clin Transl Allergy 5 2015 33
16. T.C. Theoharides, A.I. Petra, A. Taracanova, and et al. Targeting IL-33 in autoimmunity and inflammation J Pharmacol Exp Ther 354 2015 24 31
17. N.T. Martin, and M.U. Martin Interleukin 33 is a guardian of barriers and a local alarmin Nat Immunol 17 2016 122 131
18. S. Ali, A. Mohs, M. Thomas, and et al. The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription J Immunol 187 2011 1609 1616
19. H. Kayamuro, Y. Yoshioka, Y. Abe, and et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus J Virol 84 2010 12703 12712
20. D. Talabot-Ayer, N. Calo, S. Vigne, and et al. The mouse interleukin (Il)33 gene is expressed in a cell type- and stimulus-dependent manner from two alternative promoters J Leukoc Biol 91 2012 119 125
21. V. Carriere, L. Roussel, N. Ortega, and et al. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo Proc Natl Acad Sci U S A 104 2007 282 287
22. L. Roussel, M. Erard, C. Cayrol, and J.P. Girard Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket EMBO Rep 9 2008 1006 1012
23. O. Rostan, M.I. Arshad, C. Piquet-Pellorce, and et al. Crucial and diverse role of the interleukin-33/ST2 axis in infectious diseases Infect Immun 83 2015 1738 1748
24. F.Y. Liew, N.I. Pitman, and I.B. McInnes Disease-associated functions of IL-33: the new kid in the IL-1 family Nat Rev Immunol 10 2010 103 110
25. A.U. Luthi, S.P. Cullen, E.A. McNeela, and et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases Immunity 31 2009 84 98
26. M.I. Arshad, C. Piquet-Pellorce, and M. Samson IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology Liver Int 32 2012 1200 1210
27. C. Cayrol, and J.P. Girard The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1 Proc Natl Acad Sci U S A 106 2009 9021 9026
28. M. Hayakawa, H. Hayakawa, Y. Matsuyama, and et al. Mature interleukin-33 is produced by calpain-mediated cleavage in vivo Biochem Biophys Res Commun 387 2009 218 222
29. E. Lefrancais, S. Roga, V. Gautier, and et al. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G Proc Natl Acad Sci U S A 109 2012 1673 1678
30. T. Ohno, K. Oboki, N. Kajiwara, and et al. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages J Immunol 183 2009 7890 7897
31. A. Roy, G. Ganesh, H. Sippola, and et al. Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation J Biol Chem 289 2014 237 250
32. M.I. Arshad, C. Piquet-Pellorce, A. Filliol, and et al. The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver J Mol Med (Berl) 93 2015 867 878
33. K. Gao, X. Li, L Zhang, and et al. Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice Cancer Lett 335 2013 463 471
34. D.O. Villarreal, M.C. Wise, J.N. Walters, and et al. Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity Cancer Res 74 2014 1789 1800
35. A.M. Miller, D.L. Asquith, A.J. Hueber, and et al. Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice Circ Res 107 2010 650 658
36. A.M. Miller, D. Xu, D.L. Asquith, and et al. IL-33 reduces the development of atherosclerosis J Exp Med 205 2008 339 346
37. M.M. Zaiss, M. Kurowska-Stolarska, C. Bohm, and et al. IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss J Immunol 186 2011 6097 6105
38. Y. Liang, Z. Jie, L. Hou, and et al. IL-33 promotes innate IFN-gamma production and modulates dendritic cell response in LCMV-induced hepatitis in mice Eur J Immunol 45 2015 3052 3063
39. D.O. Villarreal, N. Svoronos, M.C. Wise, and et al. Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model Vaccine 33 2015 4313 4320
40. S. Li, F.X. Zhu, H.B. Zhang, and et al. Pretreatment with interleukin-33 reduces warm hepatic ischemia/reperfusion injury in mice Chin Med J (Engl) 126 2013 1855 1859
41. N. Sakai, H.L. Van Sweringen, R.C. Quillin, and et al. Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice Hepatology 56 2012 1468 1478
42. V. Volarevic, M. Mitrovic, M. Milovanovic, and et al. Protective role of IL-33/ST2 axis in Con A-induced hepatitis J Hepatol 56 2012 26 33
43. H. Yin, X. Li, S. Hu, and et al. IL-33 promotes Staphylococcus aureus-infected wound healing in mice Int Immunopharmacol 17 2013 432 438
44. L.D. Hazlett, S.A. McClellan, R.P. Barrett, and et al. IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis Invest Ophthalmol Vis Sci 51 2010 1524 1532
45. H.T. Le, V.G. Tran, W. Kim, and et al. IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals J Immunol 189 2012 287 295
46. R. Sesti-Costa, G.K. Silva, J.L. Proenca-Modena, and et al. The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis J Immunol 191 2013 283 292
47. L.A. Monticelli, L.C. Osborne, M. Noti, and et al. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions Proc Natl Acad Sci U S A 112 2015 10762 10767
48. L. Duan, J. Chen, H. Zhang, and et al. Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3(+) regulatory T-cell responses in mice Mol Med 18 2012 753 761
49. P. Grobeta, K. Doser, W. Falk, and et al. IL-33 attenuates development and perpetuation of chronic intestinal inflammation Inflamm Bowel Dis 18 2012 1900 1909
50. N.E. Humphreys, D. Xu, M.R. Hepworth, and et al. a potent inducer of adaptive immunity to intestinal nematodes J Immunol 180 2008 2443 2449
51. J.C. Alves-Filho, F. Sonego, F.O. Souto, and et al. Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection Nat Med 16 2010 708 712
52. Y. Luo, Y. Zhou, W. Xiao, and et al. Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response Brain Res 1597 2015 86 94
53. D. Canbaz, L. Utsch, A. Logiantara, and et al. IL-33 promotes the induction of immunoglobulin production after inhalation of house dust mite extract in mice Allergy 70 2015 522 532
54. D. Talabot-Ayer, P. Martin, C.A. Seemayer, and et al. Immune-mediated experimental arthritis in IL-33 deficient mice Cytokine 69 2014 68 74
55. G. Palmer, D. Talabot-Ayer, C. Lamacchia, and et al. Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis Arthritis Rheum 60 2009 738 749
56. M.I. Arshad, C. Piquet-Pellorce, A. L'Helgoualc'h, and et al. TRAIL but not FasL and TNFalpha, regulates IL-33 expression in murine hepatocytes during acute hepatitis Hepatology 56 2012 2353 2362
57. L.Y. Hung, I.P. Lewkowich, L.A. Dawson, and et al. IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms Proc Natl Acad Sci U S A 110 2013 282 287
58. P. Kropf, S. Herath, R. Klemenz, and I. Muller Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection Infect Immun 71 2003 1961 1971
59. C.C. Chuang, C.W. Chen, Y.T. Huang, and W.Y. Du Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice J Microbiol Immunol Infect 49 2016 91 96
60. P. Li, W. Lin, and X. Zheng IL-33 neutralization suppresses lupus disease in lupus-prone mice Inflammation 37 2014 824 832
61. Y. Lei, V. Boinapally, A. Zoltowska, and et al. Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma PLoS One 10 2015 e0133774
62. X. Liu, M. Li, Y. Wu, and et al. Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma Biochem Biophys Res Commun 386 2009 181 185
63. N. Mizutani, T. Nabe, and S. Yoshino Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice Immunology 139 2013 205 218
64. Y.H. Kim, T.Y. Yang, C.S. Park, and et al. Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis Allergy 67 2012 183 190
65. K. Oboki, T. Ohno, N. Kajiwara, and et al. IL-33 and IL-33 receptors in host defense and diseases Allergol Int 59 2010 143 160
66. H. Ramaprakash, T. Shibata, K.E. Duffy, and et al. Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model Am J Pathol 179 2011 104 115
67. C. Qiu, Y. Li, M. Li, and et al. Anti-interleukin-33 inhibits cigarette smoke-induced lung inflammation in mice Immunology 138 2013 76 82
68. Y. Kondo, T. Yoshimoto, K. Yasuda, and et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system Int Immunol 20 2008 791 800
69. H.J. McSorley, N.F. Blair, K.A. Smith, and et al. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy Mucosal Immunol 7 2014 1068 1078
70. D. Li, R. Guabiraba, A.G. Besnard, and et al. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice J Allergy Clin Immunol 134 1422-1432 2014 e1411
71. L.A. Monticelli, G.F. Sonnenberg, and D. Artis Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung Curr Opin Immunol 24 2012 284 289
72. J. Saravia, D. You, B. Shrestha, and et al. Respiratory syncytial virus disease is mediated by age-variable IL-33 PLoS Pathog 11 2015 e1005217
73. A. Akcay, Q. Nguyen, Z. He, and et al. IL-33 exacerbates acute kidney injury J Am Soc Nephrol 22 2011 2057 2067
74. J. Chen, L. Duan, A. Xiong, and et al. Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-gamma production in mice J Mol Med (Berl) 90 2012 1505 1515
75. Y. Liang, Z. Jie, L. Hou, and et al. IL-33 induces nuocytes and modulates liver injury in viral hepatitis J Immunol 190 2013 5666 5675
76. P.N. Pushparaj, D. Li, M. Komai-Koma, and et al. Interleukin-33 exacerbates acute colitis via interleukin-4 in mice Immunology 140 2013 70 77
77. J. Zhu, F. Yang, L. Sang, and et al. IL-33 Aggravates DSS-induced acute colitis in mouse colon lamina propria by enhancing Th2 cell responses Mediators Inflamm 2015 2015 913041
78. R. Guabiraba, A.G. Besnard, G.B. Menezes, and et al. IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice Mucosal Immunol 7 2014 1079 1093
79. L.M. Judd, R.G. Heine, T.R. Menheniott, and et al. Elevated IL-33 expression is associated with paediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice Am J Physiol Gastrointest Liver Physiol 310 2016 G13 G25
80. M. Li, Y. Li, X. Liu, and et al. IL-33 blockade suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice J Neuroimmunol 247 2012 25 31
81. D.K. Reichenbach, V. Schwarze, B.M. Matta, and et al. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD Blood 125 2015 3183 3192
82. J. Malcolm, R.A. Awang, J. Oliver-Bell, and et al. IL-33 exacerbates periodontal disease through induction of RANKL J Dent Res 94 2015 968 975
83. Y. Yu, W. Deng, and J. Lei Interleukin-33 promotes Th2 immune responses in infected mice with Schistosoma japonicum Parasitol Res 114 2015 2911 2918
84. O. Rostan, J.P. Gangneux, C. Piquet-Pellorce, and et al. The IL-33/ST2 axis is associated with human visceral leishmaniasis and suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania donovani MBio 4 2013 e00383-e00313
85. P. Han, J. Zhao, S.B. Liu, and et al. Interleukin-33 mediates formalin-induced inflammatory pain in mice Neuroscience 241 2013 59 66