Enzyme- and pH-Responsive Microencapsulated Nanogels for Oral Delivery of siRNA to Induce TNF-α Knockdown in the Intestine

Biomacromolecules

Volumn 17, Issue 3, 2016, Pages 788-797

  Knipe, Jennifer M ^a,c   Strong, Laura E ^a,c   Peppas, Nicholas A ^a,b,c  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; MICROENCAPSULATION;

ACIDIC ENVIRONMENT; CLINICAL TARGETS; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY CYTOKINES; INTESTINAL INFLAMMATION; METHACRYLIC ACIDS; MURINE MACROPHAGES; N-VINYL-2-PYRROLIDONE;

NANOSTRUCTURED MATERIALS;

NANOCARRIER; POLYMETHACRYLIC ACID; POVIDONE; SMALL INTERFERING RNA; TRYPSIN; TUMOR NECROSIS FACTOR ALPHA; 2 PYRROLIDONE DERIVATIVE; HYDROGEL; MICROCAPSULE; N-VINYL-2-PYRROLIDINONE; NANOMATERIAL; OLIGOPEPTIDE; POLYMETHACRYLIC ACID DERIVATIVE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; ENZYMATIC DEGRADATION; GENE SILENCING; GENETIC TRANSFECTION; IN VITRO STUDY; INFLAMMATORY BOWEL DISEASE; INTESTINE; MACROPHAGE; MICROENCAPSULATION; MOUSE; NANOPHARMACEUTICS; NONHUMAN; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; STOMACH PH; SYNTHESIS; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HYDROGEL; HYDROLYSIS; METABOLISM; MICROCAPSULE; PH; RNA INTERFERENCE;

ANIMALS; CAPSULES; CELL LINE; HYDROGELS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MACROPHAGES; MICE; NANOSTRUCTURES; OLIGOPEPTIDES; POLYMETHACRYLIC ACIDS; PYRROLIDINONES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRYPSIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84961160893     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/acs.biomac.5b01518     Document Type: Article

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