High glucose microenvironments inhibit the proliferation and migration of bone mesenchymal stem cells by activating GSK3β

Journal of Bone and Mineral Metabolism

Volumn 34, Issue 2, 2016, Pages 140-150

  Zhang, Bo ^a   Liu, Na ^a   Shi, Haigang ^b   Wu, Hao ^a   Gao, Yuxuan ^a   He, Huixia ^a   Gu, Bin ^a   Liu, Hongchen ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

Author keywords

GSK3 ; High glucose; SDF 1 CXCR 4 axis; Stem cells

Indexed keywords

BETA CATENIN; CD34 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYCLIN D1; ENDOGLIN; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; KI 67 ANTIGEN; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; THY 1 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE REGENERATION; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL MIGRATION; CELL PROLIFERATION; CFU COUNTING; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOFLUORESCENCE; MICROENVIRONMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE; CELL MOTION; CELL SEPARATION; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; MESENCHYMAL STROMA CELL; METABOLISM; SPRAGUE DAWLEY RAT; TUMOR MICROENVIRONMENT;

ANIMALS; BETA CATENIN; BONE AND BONES; CELL MOVEMENT; CELL PROLIFERATION; CELL SEPARATION; CELLULAR MICROENVIRONMENT; CYCLIN D1; ENZYME ACTIVATION; FEMALE; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3 BETA; LYMPHOID ENHANCER-BINDING FACTOR 1; MESENCHYMAL STROMAL CELLS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR4;

EID: 84961054154     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-015-0662-6     Document Type: Article

References (46)

1. Selea A, Sumarac-Dumanović M, Pesić M, Suluburić D, Stamenković-Pejković D, Cvijović G, Micić D (2011) The effects of education with printed material on glycemic control in patients with diabetes type 2 treated with different therapeutic regimens. Vojnosanit Pregl 68:676–683
2. Wada K, Yu W, Elazizi M, Barakat S, Ouimet MA, Rosario-Meléndez R, Fiorellini JP, Graves DT, Uhrich KE (2013) Locally delivered salicylic acid from a poly(anhydride-ester): impact on diabetic bone regeneration. J Control Release 71:33–37
3. Adami S (2009) Bone health in diabetes: considerations for clinical management. Curr Med Res Opin 25:1057–1072
4. Claes L, Recknagel S, Ignatius A (2012) Ignatius. Fracture healing under healthy and inflammatory conditions. Nat Rev Rheumatol 8:133–143
5. Roy B (2013) Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures. World J Diabetes 4:101–113
6. Yamamoto M (2013) Secondary Osteoporosis or Secondary Contributors to Bone Loss in Fracture Bone metabolic disorders in patients with diabetes mellitus. Clin Calcium 23:1327–1335
7. Caplan AI (1991) Mesenchymal stem cells. J Orthop Res 9:641–650
8. Zigdon-Giladi H, Lewinson D, Bick T, Machtei EE (2013) Mesenchymal stem cells combined with barrier domes enhance vertical bone formation. J Clin Periodontol 40:196–202
9. Kim SY, Lee JY, Park YD, Kang KL, Lee JC, Heo JS (2013) Hesperetin alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of periodontal ligament stem cells. PLoS One 28:e67504
10. Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y (2011) High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J Bone Miner Res 26:2082–2095
11. Hawkins KE, Sharp TV, McKay TR (2011) The role of hypoxia in stem cell potency and differentiation. Regen Med 8:771–782
12. Ma P, Xiong W, Liu H, Ma J, Gu B, Wu X (2011) Extrapancreatic roles of glimepiride on osteoblasts from rat manibular bone in vitro: regulation of cytodifferentiation through PI3-kinases/Akt signalling pathway. Arch Oral Biol 56:307–316
13. Song G, Habibovic P, BaoC HuJ, van Blitterswijk CA, Yuan H, Chen W, Xu HH (2013) The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinductive calcium phosphate. Biomaterials 34:2167–2176
14. Wang X, Wang Y, Gou W, Lu Q, Peng J, Lu S (2013) Role of mesenchymal stem cells in bone regeneration and fracture repair: a review. Int Orthop 37:2491–2498
15. Wynn RF, Hart CA, Corradi-Perini C, O’Neill L, Evans CA, Wraith JE, Fairbairn LJ, Bellantuono I (2004) A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 104:2643–2645
16. Rombouts WJ, Ploemacher RE (2003) Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia 17:160–170
17. Granero-Moltó F, Weis JA, Miga MI, Landis B, Landis B, Myers TJ, O’Rear L, Longobardi L, Jansen ED, Mortlock DP, Spagnoli A (2009) Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cell 27:1887–1898
18. Cao J, Wang L, Du ZJ, Liu P, Zhang YB, Sui JF, Liu YP, Lei DL (2013) Recruitment of exogenous mesenchymal stem cells in mandibular distraction osteogenesis by the stromal cell-derived factor-1/chemokine receptor-4 pathway in rats. Br J Oral Maxillofac Surg 51:937–941
19. Kitaori T, Ito H, Schwarz EM, Tsutsumi R, Yoshitomi H, Oishi S, Nakano M, Fujii N, Nagasawa T, Nakamura T (2009) Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum 60:813–823
20. Liu X, Zhou C, Li Y, Ji Y, Xu G, Wang X, Yan J (2013) SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One 8:e54077
21. Neth P, Ciccarella M, Egea V, Hoelters J, Jochum M, Ries C (2006) Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells 24:1892–1903
22. Kockeritz L, Doble B, Patel S, Woodgett JR (2006) Glycogen synthase kinase-3–anoverview of an over-achieving protein kinase. Curr Drug Targets 7:1377–1388
23. Kong X, Liu Y, Ye R, Zhu B, Zhu Y, Liu X, Hu C, Luo H, Zhang Y, Ding Y, Jin Y (2013) GSK3β is a checkpoint for TNF-α-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments. Biochim Biophys Acta 1830:5119–5129
24. Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S, Sadoshima J (2008) Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci USA 105:20900–20905
25. Kim YS, Noh MY, Kim JY, Yu HJ, Kim KS, Kim SH, Koh SH (2013) Direct GSK-3β inhibition enhances mesenchymal stromal cell migration by increasing expression of β-PIX and CXCR4. Mol Neurobiol 47:811–820
26. Liu J, Han G, Liu H, Qin C (2008) Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling. PLoS One 8:e62844
27. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D’Amico M, Pestell R, Ben-Ze’ev A (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96:5522–5527
28. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G (1993) Cyclin D1 is a nuclearprotein required for cell cycle progression in G1. Genes Dev 7:812–821
29. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Dj Prockop, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315–317
30. Kern S, Eichler H, Stoeve J, Klüter H, Bieback K (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24:1294–1301
31. Rojewski MT, Weber BM, Phenotypic Schrezenmeier H (2008) Characterization of mesenchymal stem cells from various tissues. Transfus Med Hemother 35:168–184
32. Fukumoto S, Nishizawa Y, Koyama H, Yamakawa K, Ohno S, Morii H (1997) Protein kinase C delta inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression. J Biol Chem 272:13816–13822
33. Fukumoto S, Koyama H, Hosoi M, Yamakawa K, Tanaka S, Morii H, Nishizawa Y (1999) Distinct role of cAMP and cGMP in the cell cycle control of vascular smooth muscle cells: cGMP delays cell cycle transition through suppression of cyclin D1 and cyclin-dependent kinase 4 activation. Circ Res 85:985–991
34. Kluk MJ, Hla T (2001) Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res 89:496–502
35. Ishigami M, Swertfeger DK, Granholm NA, Hui DY (1998) Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. J Biol Chem 273:20156–20161
36. Moon RT, Bowerman B, Boutros M, Perrimon N (2002) The promise and perils of Wnt signaling through beta-catenin. Science 296:1644–1646
37. Novak A (1999) Dedhar S. Signaling through beta-catenin and Lef/Tcf. Cell Mol Life Sci 56:523–537
38. Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P (1997) Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. Oncogene 15:2833–2839
39. Koehler A, Schlupf J, Schneider M, Kraft B, Winter C, Kashef J (2013) Loss of Xenopus cadherin-11 leads to increased Wnt/β-catenin signaling and up-regulation of target genes c-myc and cyclin D1 in neural crest. Dev Biol 383:132–145
40. Gopalakrishnan V, Vignesh RC, Arunakaran J, Aruldhas MM, Srinivasan N (2006) Effects of glucose and its modulation by insulin and estradiol on BMSC differentiation into osteoblastic lineages. Biochem Cell Biol 84:93–101
41. Abbott J, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ (2004) Stromal cell-derived factor-1 alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110:3300–3305
42. Ji J, He B, Dheen S, Tay S (2004) Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Stem Cells 22:415–427
43. Ceradini D, Kulkarni A, Callaghan M, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10:858–864
44. Chang G, Zhang H, Wang J, Zhang Y, Xu H, Wang C, Zhang H, Ma L, Li Q, Pang T (2013) CD44 targets Wnt/β-catenin pathway to mediate the proliferation of K562 cells. Cancer Cell Int 13:117
45. Cho J, Rameshwar P, Sadoshima J (2009) Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. J Biol Chem 284:36647–36658
46. Gagliardi M, Hernandez A, McGough IJ, Vincent JP (2014) Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal β-catenin/Armadillo. J Cell Sci 127:4918–4926