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Volumn 8, Issue 6, 2013, Pages

Hesperetin Alleviates the Inhibitory Effects of High Glucose on the Osteoblastic Differentiation of Periodontal Ligament Stem Cells

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; GLUCOSE; HESPERETIN; MESSENGER RNA; OSTEOPONTIN; PROTEIN KINASE B; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

EID: 84879528858     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067504     Document Type: Article
Times cited : (64)

References (43)
  • 3
    • 3042749378 scopus 로고    scopus 로고
    • Investigation of multipotent postnatal stem cells from human periodontal ligament
    • Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, et al. (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364: 149-155.
    • (2004) Lancet , vol.364 , pp. 149-155
    • Seo, B.M.1    Miura, M.2    Gronthos, S.3    Bartold, P.M.4    Batouli, S.5
  • 4
    • 70350520836 scopus 로고    scopus 로고
    • Isolation and characterization of stem cell clones from adult human ligament
    • Singhatanadgit W, Donos N, Olsen I, (2009) Isolation and characterization of stem cell clones from adult human ligament. Tissue Eng A 15: 2625-2636.
    • (2009) Tissue Eng A , vol.15 , pp. 2625-2636
    • Singhatanadgit, W.1    Donos, N.2    Olsen, I.3
  • 6
    • 70649097210 scopus 로고    scopus 로고
    • Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration
    • Nakashima M, Iohara K, Sugiyama M, (2009) Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration. Cytokine Growth Factor Rev 20: 435-440.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 435-440
    • Nakashima, M.1    Iohara, K.2    Sugiyama, M.3
  • 8
    • 77953230526 scopus 로고    scopus 로고
    • Osteogenic differentiation of stem cells derived from human periodontal ligaments and pulp of human exfoliated deciduous teeth
    • Chadipiralla K, Yochim JM, Bahuleyan B, Huang CY, Garcia-Godoy F, et al. (2010) Osteogenic differentiation of stem cells derived from human periodontal ligaments and pulp of human exfoliated deciduous teeth. Cell Tissue Res 340: 323-333.
    • (2010) Cell Tissue Res , vol.340 , pp. 323-333
    • Chadipiralla, K.1    Yochim, J.M.2    Bahuleyan, B.3    Huang, C.Y.4    Garcia-Godoy, F.5
  • 9
    • 33749579010 scopus 로고    scopus 로고
    • Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis
    • Iohara K, Zheng L, Ito M, Tomokiyo A, Matsushita K, et al. (2006) Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells 24: 2493-2503.
    • (2006) Stem Cells , vol.24 , pp. 2493-2503
    • Iohara, K.1    Zheng, L.2    Ito, M.3    Tomokiyo, A.4    Matsushita, K.5
  • 10
    • 84870352549 scopus 로고    scopus 로고
    • Bone repair by periodontal ligament stem cell seeded nanohydroxyapatite-chitosan scaffold
    • Ge S, Zhao N, Wang L, Yu M, Liu H, et al. (2012) Bone repair by periodontal ligament stem cell seeded nanohydroxyapatite-chitosan scaffold. Int J Nanomedicine 7: 5405-5414.
    • (2012) Int J Nanomedicine , vol.7 , pp. 5405-5414
    • Ge, S.1    Zhao, N.2    Wang, L.3    Yu, M.4    Liu, H.5
  • 12
    • 50249107854 scopus 로고    scopus 로고
    • Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks
    • Salvi GE, Carollo-Bittel B, Lang NP, (2008) Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol 35: 398-409.
    • (2008) J Clin Periodontol , vol.35 , pp. 398-409
    • Salvi, G.E.1    Carollo-Bittel, B.2    Lang, N.P.3
  • 14
    • 0035667114 scopus 로고    scopus 로고
    • Chemistry and pharmacology of the citrus bioflavonoid hesperidin
    • Garg A, Garg S, Zaneveld LJ, Singla AK, (2001) Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res 15: 655-669.
    • (2001) Phytother Res , vol.15 , pp. 655-669
    • Garg, A.1    Garg, S.2    Zaneveld, L.J.3    Singla, A.K.4
  • 15
    • 0028036694 scopus 로고
    • Biological effects of hesperidin, a citrus flavonoid: Note I. Antiinflammatory and analgesic activity
    • Galati EM, Monforte MT, Kirjavainen S, Forestieri AM, Trovato A, et al. (1994) Biological effects of hesperidin, a citrus flavonoid: Note I. Antiinflammatory and analgesic activity. Farmaco 40: 709-712.
    • (1994) Farmaco , vol.40 , pp. 709-712
    • Galati, E.M.1    Monforte, M.T.2    Kirjavainen, S.3    Forestieri, A.M.4    Trovato, A.5
  • 16
    • 0031870664 scopus 로고    scopus 로고
    • Protective effects of lemon flavonoids on oxidative stress in diabetic rats
    • Miyake Y, Yamamoto K, Tsujihara N, Osawa T, (1998) Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids 33: 689-695.
    • (1998) Lipids , vol.33 , pp. 689-695
    • Miyake, Y.1    Yamamoto, K.2    Tsujihara, N.3    Osawa, T.4
  • 17
    • 75249107678 scopus 로고    scopus 로고
    • Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation
    • Trzeciakiewicz A, Habauzit V, Mercier S, Barron D, Urpi-Sarda M, et al. (2010) Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation. J Agric Food Chem 58: 668-675.
    • (2010) J Agric Food Chem , vol.58 , pp. 668-675
    • Trzeciakiewicz, A.1    Habauzit, V.2    Mercier, S.3    Barron, D.4    Urpi-Sarda, M.5
  • 18
    • 42549148447 scopus 로고    scopus 로고
    • Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation
    • Choi EM, Kim YH, (2008) Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation. Cell Biol Toxicol 24: 225-231.
    • (2008) Cell Biol Toxicol , vol.24 , pp. 225-231
    • Choi, E.M.1    Kim, Y.H.2
  • 19
    • 84871244544 scopus 로고    scopus 로고
    • The flavonoids hesperidin and rutin promote neural crest cell survival
    • Nones J, Costa AP, Leal RB, Gomes FC, Trentin AG, (2012) The flavonoids hesperidin and rutin promote neural crest cell survival. Cell Tissue Res 350: 305-315.
    • (2012) Cell Tissue Res , vol.350 , pp. 305-315
    • Nones, J.1    Costa, A.P.2    Leal, R.B.3    Gomes, F.C.4    Trentin, A.G.5
  • 20
    • 84874889686 scopus 로고    scopus 로고
    • Effects Of Natural Compounds On Xenopus Embryogenesis: A Potential Read Out For Functional Drug Discovery Targeting Wnt/β-Catenin Signaling
    • Amado N, Fonseca B, Cerqueira DM, Reis AH, Simas AB, et al. (2012) Effects Of Natural Compounds On Xenopus Embryogenesis: A Potential Read Out For Functional Drug Discovery Targeting Wnt/β-Catenin Signaling. Curr Top Med Chem 12: 2103-2113.
    • (2012) Curr Top Med Chem , vol.12 , pp. 2103-2113
    • Amado, N.1    Fonseca, B.2    Cerqueira, D.M.3    Reis, A.H.4    Simas, A.B.5
  • 21
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 22
    • 28444434774 scopus 로고    scopus 로고
    • BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-κB activation in rat brain astrocytes
    • Hsieh HL, Wu CY, Hwang TL, Yen MH, Parker P, et al. (2006) BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-κB activation in rat brain astrocytes. J Cell Physiol 206: 246-254.
    • (2006) J Cell Physiol , vol.206 , pp. 246-254
    • Hsieh, H.L.1    Wu, C.Y.2    Hwang, T.L.3    Yen, M.H.4    Parker, P.5
  • 23
    • 33745728365 scopus 로고    scopus 로고
    • Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants
    • Ali MH, Mungai PT, Schumacker PT, (2006) Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants. Am J Physiol Lung Cell Mol Physiol 291: L38-45.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Ali, M.H.1    Mungai, P.T.2    Schumacker, P.T.3
  • 24
    • 3042625013 scopus 로고    scopus 로고
    • Hesperetin: a potent antioxidant against peroxynitrite
    • Kim JY, Jung KJ, Choi JS, Chung HY, (2004) Hesperetin: a potent antioxidant against peroxynitrite. Free Radic Res 38: 761-769.
    • (2004) Free Radic Res , vol.38 , pp. 761-769
    • Kim, J.Y.1    Jung, K.J.2    Choi, J.S.3    Chung, H.Y.4
  • 25
    • 84860451639 scopus 로고    scopus 로고
    • Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats
    • Pari L, Shagirtha K, (2012) Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats. Exp Toxicol Pathol 64: 513-520.
    • (2012) Exp Toxicol Pathol , vol.64 , pp. 513-520
    • Pari, L.1    Shagirtha, K.2
  • 26
    • 0031963225 scopus 로고    scopus 로고
    • Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells
    • Terada M, Inaba M, Yano Y, Hasuma T, Nishizawa Y, et al. (1998) Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells. Bone 22: 17-23.
    • (1998) Bone , vol.22 , pp. 17-23
    • Terada, M.1    Inaba, M.2    Yano, Y.3    Hasuma, T.4    Nishizawa, Y.5
  • 27
    • 0035155069 scopus 로고    scopus 로고
    • Glucose-induced inhibition of in vitro bone mineralization
    • Balint E, Szabo P, Marshall CF, Sprague SM, (2001) Glucose-induced inhibition of in vitro bone mineralization. Bone (NY) 28: 21-28.
    • (2001) Bone (NY) , vol.28 , pp. 21-28
    • Balint, E.1    Szabo, P.2    Marshall, C.F.3    Sprague, S.M.4
  • 28
    • 0033162592 scopus 로고    scopus 로고
    • Periodontal ligament cells from insulin-dependent diabetics exhibit altered alkaline phosphatase activity in response to growth factors
    • Hobbs HC, Rowe DJ, Johnson PW, (1999) Periodontal ligament cells from insulin-dependent diabetics exhibit altered alkaline phosphatase activity in response to growth factors. J Periodontol 70: 736-742.
    • (1999) J Periodontol , vol.70 , pp. 736-742
    • Hobbs, H.C.1    Rowe, D.J.2    Johnson, P.W.3
  • 29
    • 33751321656 scopus 로고    scopus 로고
    • Effects of high glucose on cellular activity of periodontal ligament cells in vitro
    • Kim HS, Park JW, Yeo SI, Choi BJ, Suh JY, (2006) Effects of high glucose on cellular activity of periodontal ligament cells in vitro. Diabetes Res Clin Pract 74: 41-47.
    • (2006) Diabetes Res Clin Pract , vol.74 , pp. 41-47
    • Kim, H.S.1    Park, J.W.2    Yeo, S.I.3    Choi, B.J.4    Suh, J.Y.5
  • 30
    • 77649136214 scopus 로고    scopus 로고
    • Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells
    • Kao CL, Tai LK, Chiou SH, Chen YJ, Lee KH, et al. (2010) Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells. Stem Cells Dev 19: 247-258.
    • (2010) Stem Cells Dev , vol.19 , pp. 247-258
    • Kao, C.L.1    Tai, L.K.2    Chiou, S.H.3    Chen, Y.J.4    Lee, K.H.5
  • 31
    • 80053103834 scopus 로고    scopus 로고
    • Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro
    • Ko CH, Siu WS, Wong HL, Shum WT, Fung KP, et al. (2011) Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro. J Agric Food Chem 59: 9870-9876.
    • (2011) J Agric Food Chem , vol.59 , pp. 9870-9876
    • Ko, C.H.1    Siu, W.S.2    Wong, H.L.3    Shum, W.T.4    Fung, K.P.5
  • 32
    • 77951499397 scopus 로고    scopus 로고
    • Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway
    • Trzeciakiewicz A, Habauzit V, Mercier S, Lebecque P, Davicco MJ, et al. (2010) Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway. J Nutr Biochem 21: 424-431.
    • (2010) J Nutr Biochem , vol.21 , pp. 424-431
    • Trzeciakiewicz, A.1    Habauzit, V.2    Mercier, S.3    Lebecque, P.4    Davicco, M.J.5
  • 33
    • 0037155860 scopus 로고    scopus 로고
    • High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly
    • Clarkson MR, Murphy M, Gupta S, Lambe T, Mackenzie HS, et al. (2002) High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. J Biol Chem 277: 9707-9712.
    • (2002) J Biol Chem , vol.277 , pp. 9707-9712
    • Clarkson, M.R.1    Murphy, M.2    Gupta, S.3    Lambe, T.4    Mackenzie, H.S.5
  • 34
    • 33747203025 scopus 로고    scopus 로고
    • Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells
    • Choi EJ, Kim GD, Chee KM, Kim GH, (2006) Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells. Nutrition 22: 947-951.
    • (2006) Nutrition , vol.22 , pp. 947-951
    • Choi, E.J.1    Kim, G.D.2    Chee, K.M.3    Kim, G.H.4
  • 35
    • 26444564340 scopus 로고    scopus 로고
    • Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells
    • Shouhed D, Kha HT, Richardson JA, Amantea CM, Hahn TJ, et al. (2005) Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. J Cell Biochem 95: 1276-1283.
    • (2005) J Cell Biochem , vol.95 , pp. 1276-1283
    • Shouhed, D.1    Kha, H.T.2    Richardson, J.A.3    Amantea, C.M.4    Hahn, T.J.5
  • 36
    • 78649875480 scopus 로고    scopus 로고
    • Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress
    • Kim WK, Meliton V, Bourquard N, Hahn TJ, Parhami F, (2010) Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress. J Cell Biochem 111: 1199-1209.
    • (2010) J Cell Biochem , vol.111 , pp. 1199-1209
    • Kim, W.K.1    Meliton, V.2    Bourquard, N.3    Hahn, T.J.4    Parhami, F.5
  • 37
    • 79960076098 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on TEGDMA- and HEMA-induced suppression of osteogenic differentiation of human osteosarcoma MG63 cells
    • Kim NR, Lim BS, Park HC, Son KM, Yang HC, (2011) Effects of N-acetylcysteine on TEGDMA- and HEMA-induced suppression of osteogenic differentiation of human osteosarcoma MG63 cells. J Biomed Mater Res B Appl Biomater 98B: 300-307.
    • (2011) J Biomed Mater Res B Appl Biomater , vol.98 B , pp. 300-307
    • Kim, N.R.1    Lim, B.S.2    Park, H.C.3    Son, K.M.4    Yang, H.C.5
  • 38
    • 45049085983 scopus 로고    scopus 로고
    • Genetic networks of cooperative redox regulation of osteopontin
    • Partridge CR, He Q, Brun M, Ramos KS, (2008) Genetic networks of cooperative redox regulation of osteopontin. Matrix Biol 27: 462-474.
    • (2008) Matrix Biol , vol.27 , pp. 462-474
    • Partridge, C.R.1    He, Q.2    Brun, M.3    Ramos, K.S.4
  • 39
    • 0038624395 scopus 로고    scopus 로고
    • Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    • Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, et al. (2003) Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365.
    • (2003) Genes Dev , vol.17 , pp. 1352-1365
    • Peng, X.D.1    Xu, P.Z.2    Chen, M.L.3    Hahn-Windgassen, A.4    Skeen, J.5
  • 40
    • 58649087137 scopus 로고    scopus 로고
    • Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone
    • Williams BO, Insogna KL, (2009) Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. J Bone Miner Res 24: 171-178.
    • (2009) J Bone Miner Res , vol.24 , pp. 171-178
    • Williams, B.O.1    Insogna, K.L.2
  • 41
    • 42349100414 scopus 로고    scopus 로고
    • Akt1 in osteoblasts and osteoclasts controls bone remodeling
    • Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, et al. (2007) Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One 2: e1058.
    • (2007) PLoS One , vol.2
    • Kawamura, N.1    Kugimiya, F.2    Oshima, Y.3    Ohba, S.4    Ikeda, T.5
  • 42
    • 75749094782 scopus 로고    scopus 로고
    • Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation
    • Mukherjee A, Wilson EM, Rotwein P, (2010) Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation. Mol Cell Biol 30: 1018-1027.
    • (2010) Mol Cell Biol , vol.30 , pp. 1018-1027
    • Mukherjee, A.1    Wilson, E.M.2    Rotwein, P.3
  • 43
    • 84867015492 scopus 로고    scopus 로고
    • Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells
    • Hwang SL, Lin JA, Shih PH, Yeh CT, Yen GC, (2012) Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells. Food Funct 3: 1082-1090.
    • (2012) Food Funct , vol.3 , pp. 1082-1090
    • Hwang, S.L.1    Lin, J.A.2    Shih, P.H.3    Yeh, C.T.4    Yen, G.C.5


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