Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice

Journal of Neuroimmunology

Volumn 292, Issue , 2016, Pages 58-67

  Sun, Yafei ^a   Tian, Tian ^b   Gao, Juan ^c   Liu, Xiaoqian ^a   Hou, Huiqing ^a,d   Cao, Runjing ^a   Li, Bin ^a,d   Quan, Moyuan ^a   Guo, Li ^a,d  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b CHENGDE MEDICAL COLLEGE   (China)

^c HEBEI UNIVERSITY   (China)

^d Key Laboratory of Hebei Neurology   (China)

Author keywords

AMPK mTOR; Experimental autoimmune encephalomyelitis; Metformin; Multiple sclerosis; Th17 cells; Treg cells

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; ANTIDIABETIC AGENT; CYTOKINE; HIF1A PROTEIN, MOUSE; MESSENGER RNA; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL DENSITY; CELL METABOLISM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENSITOMETRY; DNA SYNTHESIS; DRUG ACTIVITY; ENZYME ACTIVATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; RNA ISOLATION; TH17 CELL; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; METABOLISM;

ANALYSIS OF VARIANCE; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HYPOGLYCEMIC AGENTS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; METFORMIN; MICE; MICE, INBRED C57BL; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84960926090     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2016.01.014     Document Type: Article

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