메뉴 건너뛰기




Volumn 101, Issue 3, 2016, Pages 1123-1133

Metabolic effects of long-term reduction in free fatty acids with acipimox in obesity: A randomized trial

Author keywords

[No Author keywords available]

Indexed keywords

ACIPIMOX; ADIPONECTIN; CHOLESTEROL; CREATINE PHOSPHATE; FATTY ACID; GLUCOSE; INSULIN; LOW DENSITY LIPOPROTEIN; PLACEBO; TRIACYLGLYCEROL; ANTILIPEMIC AGENT; GLUCOSE BLOOD LEVEL; PYRAZINE DERIVATIVE;

EID: 84960883859     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-3696     Document Type: Article
Times cited : (23)

References (57)
  • 1
    • 77953466400 scopus 로고    scopus 로고
    • Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle
    • Brehm A. Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle. Am J Physiol Endocrinol Metab. 2010;299:E33-E38.
    • (2010) Am J Physiol Endocrinol Metab. , vol.299 , pp. E33-E38
    • Brehm, A.1
  • 2
    • 33644746318 scopus 로고    scopus 로고
    • Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle
    • Brehm A, Krssak M, Schmid AI, Nowotny P, Waldhäusl W, Roden M. Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes. 2006;55(1):136-140.
    • (2006) Diabetes. , vol.55 , Issue.1 , pp. 136-140
    • Brehm, A.1    Krssak, M.2    Schmid, A.I.3    Nowotny, P.4    Waldhäusl, W.5    Roden, M.6
  • 3
    • 20044390768 scopus 로고    scopus 로고
    • Dose-response effect of elevated plasma free fatty acid on insulin signaling
    • Belfort R, Mandarino L, Kashyap S, et al. Dose-response effect of elevated plasma free fatty acid on insulin signaling. Diabetes. 2005; 54(6):1640-1648.
    • (2005) Diabetes. , vol.54 , Issue.6 , pp. 1640-1648
    • Belfort, R.1    Mandarino, L.2    Kashyap, S.3
  • 4
    • 33847347318 scopus 로고    scopus 로고
    • Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration
    • Bajaj M, Medina-Navarro R, Suraamornkul S, Meyer C, De Fronzo RA, Mandarino LJ. Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration. Diabetes. 2007;56(3):743-752.
    • (2007) Diabetes. , vol.56 , Issue.3 , pp. 743-752
    • Bajaj, M.1    Medina-Navarro, R.2    Suraamornkul, S.3    Meyer, C.4    De Fronzo, R.A.5    Mandarino, L.J.6
  • 5
    • 33644695097 scopus 로고    scopus 로고
    • Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-Co As and insulin action in type 2 diabetic patients
    • Bajaj M, Suraamornkul S, Romanelli A, et al. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-Co As and insulin action in type 2 diabetic patients. Diabetes. 2005;54(11):3148-3153.
    • (2005) Diabetes. , vol.54 , Issue.11 , pp. 3148-3153
    • Bajaj, M.1    Suraamornkul, S.2    Romanelli, A.3
  • 6
    • 0026489172 scopus 로고
    • A double blind study of the effect of acipimox on serum lipids, blood glucose control and insulin action in non-obese patients with type 2 diabetes mellitus
    • Fulcher GR, Catalano C, Walker M, et al. A double blind study of the effect of acipimox on serum lipids, blood glucose control and insulin action in non-obese patients with type 2 diabetes mellitus. Diabet Med. 1992;9(10):908-914.
    • (1992) Diabet Med. , vol.9 , Issue.10 , pp. 908-914
    • Fulcher, G.R.1    Catalano, C.2    Walker, M.3
  • 7
    • 0032829745 scopus 로고    scopus 로고
    • Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects
    • Santomauro AT, Boden G, Silva ME, et al. Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes. 1999;48(9):1836-1841.
    • (1999) Diabetes. , vol.48 , Issue.9 , pp. 1836-1841
    • Santomauro, A.T.1    Boden, G.2    Silva, M.E.3
  • 8
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002;277(52):50230-50626.
    • (2002) J Biol Chem. , vol.277 , Issue.52 , pp. 50230-50626
    • Yu, C.1    Chen, Y.2    Cline, G.W.3
  • 9
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C 0 and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C 0 and alterations in the insulin signaling cascade. Diabetes. 1999; 48(6):1270-1274.
    • (1999) Diabetes. , vol.48 , Issue.6 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 11
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated re-ceptor-7 co-activator 1a-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
    • Koves TR, Li P, An J, et al. Peroxisome proliferator-activated re-ceptor-7 co-activator 1a-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem. 2005;280(39):33588-33598.
    • (2005) J Biol Chem. , vol.280 , Issue.39 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3
  • 12
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008;7(1):45-56.
    • (2008) Cell Metab. , vol.7 , Issue.1 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3
  • 13
    • 0031769691 scopus 로고    scopus 로고
    • Tolerability and effects of high doses acipimox as additional lipid-lowering therapy in familial hypercholesterolemia
    • Stuyt PM, Kleinjans HA, Stalenhoef AF. Tolerability and effects of high doses acipimox as additional lipid-lowering therapy in familial hypercholesterolemia. Neth J Med. 1998;53(5):228-233.
    • (1998) Neth J Med. , vol.53 , Issue.5 , pp. 228-233
    • Stuyt, P.M.1    Kleinjans, H.A.2    Stalenhoef, A.F.3
  • 14
    • 0023883064 scopus 로고
    • Plasma lipid lowering activity of acipimox in patients with type II and type IV hyperlipoproteinemia. Results of a multicenter trial
    • Crepaldi G, Avogaro P, Descovich GC, et al. Plasma lipid lowering activity of acipimox in patients with type II and type IV hyperlipoproteinemia. Results of a multicenter trial. Atherosclerosis. 1988; 70:115-121.
    • (1988) Atherosclerosis. , vol.70 , pp. 115-121
    • Crepaldi, G.1    Avogaro, P.2    Descovich, G.C.3
  • 15
    • 33751502484 scopus 로고    scopus 로고
    • Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia
    • Hadigan C, Liebau J, Torriani M, Andersen R, Grinspoon S. Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia. J Clin Endocrinol Metab. 2006; 91(11):4438-4444.
    • (2006) J Clin Endocrinol Metab. , vol.91 , Issue.11 , pp. 4438-4444
    • Hadigan, C.1    Liebau, J.2    Torriani, M.3    Andersen, R.4    Grinspoon, S.5
  • 16
    • 77958051227 scopus 로고    scopus 로고
    • Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function
    • Halbirk M, Nørrelund H, Møller N, et al. Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function. Am J Physiol Heart Circ Physiol. 2010;299(4):H1220-H1225.
    • (2010) Am J Physiol Heart Circ Physiol. , vol.299 , Issue.4 , pp. H1220-H1225
    • Halbirk, M.1    Nørrelund, H.2    Møller, N.3
  • 17
    • 84962030356 scopus 로고    scopus 로고
    • Evidence for a direct effect of the NAD + precursor acipimox on muscle mitochondrial function in humans
    • van de Weijer T, Phielix E, Bilet L, et al. Evidence for a direct effect of the NAD + precursor acipimox on muscle mitochondrial function in humans. Diabetes. 2015;64(4):1193-1201.
    • (2015) Diabetes. , vol.64 , Issue.4 , pp. 1193-1201
    • Van De Weijer, T.1    Phielix, E.2    Bilet, L.3
  • 18
    • 84904959809 scopus 로고    scopus 로고
    • Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals
    • Daniele G, Eldor R, Merovci A, et al. Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals. Diabetes. 2014;63(8):2812-2820.
    • (2014) Diabetes. , vol.63 , Issue.8 , pp. 2812-2820
    • Daniele, G.1    Eldor, R.2    Merovci, A.3
  • 19
    • 84894564179 scopus 로고    scopus 로고
    • Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: A randomised clinical trial
    • Phielix E, Jelenik T, Nowotny P, Szendroedi J, Roden M. Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial. Diabetologia.2014;57(3):572-581.
    • (2014) Diabetologia. , vol.57 , Issue.3 , pp. 572-581
    • Phielix, E.1    Jelenik, T.2    Nowotny, P.3    Szendroedi, J.4    Roden, M.5
  • 20
    • 79955164346 scopus 로고    scopus 로고
    • Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome
    • Montecucco F, Bertolotto M, Vuilleumier N, et al. Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome. Am J Physiol Endocrinol Metab. 2011;300(4): E681-E690.
    • (2011) Am J Physiol Endocrinol Metab. , vol.300 , Issue.4 , pp. E681-E690
    • Montecucco, F.1    Bertolotto, M.2    Vuilleumier, N.3
  • 21
    • 0028203880 scopus 로고
    • Pronounced blood glucose-lowering effect of the antili-polytic drug acipimox in noninsulin-dependent diabetes mellitus patients during a 3-day intensified treatment period
    • Worm D, Henriksen JE, Vaag A, Thye-Rønn P, Melander A, Beck-Nielsen H. Pronounced blood glucose-lowering effect of the antili-polytic drug acipimox in noninsulin-dependent diabetes mellitus patients during a 3-day intensified treatment period. J Clin Endocrinol Metab. 1994;78(3):717-721.
    • (1994) J Clin Endocrinol Metab. , vol.78 , Issue.3 , pp. 717-721
    • Worm, D.1    Henriksen, J.E.2    Vaag, A.3    Thye-Rønn, P.4    Melander, A.5    Beck-Nielsen, H.6
  • 22
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419.
    • (1985) Diabetologia. , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 23
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program
    • Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998;21(12):2191-2192.
    • (1998) Diabetes Care. , vol.21 , Issue.12 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3
  • 25
    • 84922522978 scopus 로고    scopus 로고
    • Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phos-phocreatine recovery after exercise in obese men with reduced GH
    • Hamarneh SR, Murphy CA, Shih CW, et al. Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phos-phocreatine recovery after exercise in obese men with reduced GH. J Clin Endocrinol Metab. 2015;100(2):617-625.
    • (2015) J Clin Endocrinol Metab. , vol.100 , Issue.2 , pp. 617-625
    • Hamarneh, S.R.1    Murphy, C.A.2    Shih, C.W.3
  • 26
    • 0034707895 scopus 로고    scopus 로고
    • 31P magnetic resonance spectroscopy study of phosphocreatine recovery kinetics in skeletal muscle: The issue of intersubject variability
    • Roussel M, Bendahan D, Mattei JP, Le Fur Y, Cozzone PJ. 31P magnetic resonance spectroscopy study of phosphocreatine recovery kinetics in skeletal muscle: the issue of intersubject variability. Biochim Biophys Acta. 2000;1457:18-26.
    • (2000) Biochim Biophys Acta. , vol.1457 , pp. 18-26
    • Roussel, M.1    Bendahan, D.2    Mattei, J.P.3    Le Fur, Y.4    Cozzone, P.J.5
  • 28
    • 0016723939 scopus 로고
    • Percutaneous needle biopsy of skeletal muscle in physiological and clinical research
    • Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest. 1975;35(7): 609-616.
    • (1975) Scand J Clin Lab Invest. , vol.35 , Issue.7 , pp. 609-616
    • Bergstrom, J.1
  • 29
    • 0020024468 scopus 로고
    • Suction applied to a muscle biopsy maximizes sample size
    • Evans WJ, Phinney SD, Young VR. Suction applied to a muscle biopsy maximizes sample size. Med Sci Sports Exerc. 1982;14(1): 101-102.
    • (1982) Med Sci Sports Exerc. , vol.14 , Issue.1 , pp. 101-102
    • Evans, W.J.1    Phinney, S.D.2    Young, V.R.3
  • 30
    • 39049127051 scopus 로고    scopus 로고
    • Hepatic insulin resistance in antipsychotic naive schizophrenic patients: Stable isotope studies of glucose metabolism
    • van Nimwegen LJ, Storosum JG, Blumer RM, et al. Hepatic insulin resistance in antipsychotic naive schizophrenic patients: stable isotope studies of glucose metabolism. J Clin Endocrinol Metab. 2008; 93(2):572-577.
    • (2008) J Clin Endocrinol Metab. , vol.93 , Issue.2 , pp. 572-577
    • Van Nimwegen, L.J.1    Storosum, J.G.2    Blumer, R.M.3
  • 31
    • 84878592132 scopus 로고    scopus 로고
    • A ~60-min brisk walk increases insulin-stimulated glucose disposal but has no effect on hepatic and adipose tissue insulin sensitivity in older women
    • Wang X, Patterson BW, Smith GI, et al. A ~60-min brisk walk increases insulin-stimulated glucose disposal but has no effect on hepatic and adipose tissue insulin sensitivity in older women. J Appl Physiol (1985). 2013;114(11):1563-1568.
    • (2013) J Appl Physiol (1985). , vol.114 , Issue.11 , pp. 1563-1568
    • Wang, X.1    Patterson, B.W.2    Smith, G.I.3
  • 32
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • De Fronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214-E223.
    • (1979) Am J Physiol. , vol.237 , pp. E214-E223
    • De Fronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 35
    • 0025303078 scopus 로고
    • Dual-energy X-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition
    • Mazess RB, Barden HS, Bisek JP, Hanson J. Dual-energy X-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr. 1990;51(6):1106-1112.
    • (1990) Am J Clin Nutr. , vol.51 , Issue.6 , pp. 1106-1112
    • Mazess, R.B.1    Barden, H.S.2    Bisek, J.P.3    Hanson, J.4
  • 37
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol. 1999;277:E1130-E1141.
    • (1999) Am J Physiol. , vol.277 , pp. E1130-E1141
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 40
    • 0029159782 scopus 로고
    • Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy
    • Sinnwell TM, Sivakumar K, Soueidan S, et al. Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy. J Clin Invest. 1995;96(1):126-131.
    • (1995) J Clin Invest. , vol.96 , Issue.1 , pp. 126-131
    • Sinnwell, T.M.1    Sivakumar, K.2    Soueidan, S.3
  • 41
    • 0001661419 scopus 로고
    • Analysis of extreme values
    • Dixon WJ. Analysis of extreme values. Ann Math Stat. 1950;421: 488-506.
    • (1950) Ann Math Stat. , vol.421 , pp. 488-506
    • Dixon, W.J.1
  • 42
    • 0025031812 scopus 로고
    • No adjustments are needed for multiple comparisons
    • Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology. 1990;1(1):43-46.
    • (1990) Epidemiology. , vol.1 , Issue.1 , pp. 43-46
    • Rothman, K.J.1
  • 43
    • 84903891867 scopus 로고    scopus 로고
    • Six persistent research misconceptions
    • Rothman KJ. Six persistent research misconceptions. J Gen Intern Med. 2014;29(7):1060-1064.
    • (2014) J Gen Intern Med. , vol.29 , Issue.7 , pp. 1060-1064
    • Rothman, K.J.1
  • 44
    • 77953395873 scopus 로고    scopus 로고
    • CONSORT 2010 statement: Updated guidelines for reporting parallel group randomized trials
    • Schulz KF, Altman DG, Moher D, CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med. 2010;152(11):726-732.
    • (2010) Ann Intern Med. , vol.152 , Issue.11 , pp. 726-732
    • Schulz, K.F.1    Altman, D.G.2    Moher, D.3
  • 45
    • 34547588219 scopus 로고    scopus 로고
    • Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    • Turner N. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes. 2007;56:2085-2092.
    • (2007) Diabetes. , vol.56 , pp. 2085-2092
    • Turner, N.1
  • 46
    • 77955633231 scopus 로고    scopus 로고
    • Chronic AMP-activated protein kinase activation and a high-fat diet have an additive effect on mitochondria in rat skeletal muscle
    • Fillmore N, Jacobs DL, Mills DB, Winder WW, Hancock CR. Chronic AMP-activated protein kinase activation and a high-fat diet have an additive effect on mitochondria in rat skeletal muscle. J Appl Physiol. 2010;109(2):511-520.
    • (2010) J Appl Physiol. , vol.109 , Issue.2 , pp. 511-520
    • Fillmore, N.1    Jacobs, D.L.2    Mills, D.B.3    Winder, W.W.4    Hancock, C.R.5
  • 47
    • 45549089279 scopus 로고    scopus 로고
    • High-fat diets cause insulin resistance despite an increase in muscle mitochondria
    • Hancock CR. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci USA. 2008;105: 7815-7820.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 7815-7820
    • Hancock, C.R.1
  • 48
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • Dresner A, Laurent D, Marcucci M, et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 1999;103(2):253-259.
    • (1999) J Clin Invest. , vol.103 , Issue.2 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3
  • 49
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou YP, Grill V. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab. 1995;80(5):1584-1590.
    • (1995) J Clin Endocrinol Metab. , vol.80 , Issue.5 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2
  • 50
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest. 1994;93(2):870-876.
    • (1994) J Clin Invest. , vol.93 , Issue.2 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2
  • 51
    • 34248141686 scopus 로고    scopus 로고
    • Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
    • Befroy DE, Petersen KF, Dufour S, et al. Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes. 2007;56(5):1376-1381.
    • (2007) Diabetes. , vol.56 , Issue.5 , pp. 1376-1381
    • Befroy, D.E.1    Petersen, K.F.2    Dufour, S.3
  • 52
    • 84907386500 scopus 로고    scopus 로고
    • Ectopic fat in insulin resistance, dyslipidemia, and car-diometabolic disease
    • Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and car-diometabolic disease. N Engl J Med. 2014;371(12):1131-1141.
    • (2014) N Engl J Med. , vol.371 , Issue.12 , pp. 1131-1141
    • Shulman, G.I.1
  • 53
    • 84958880102 scopus 로고    scopus 로고
    • Niacin therapy and the risk of new-onset diabetes: A meta-analysis of randomised controlled trials [published online September 14, 2015]
    • Goldie C, Taylor AJ, Nguyen P, McCoy C, Zhao XQ, Preiss D. Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomised controlled trials [published online September 14, 2015]. Heart. doi:10.1136/heartjnl-2015-308055.
    • Heart
    • Goldie, C.1    Taylor, A.J.2    Nguyen, P.3    McCoy, C.4    Zhao, X.Q.5    Preiss, D.6
  • 54
    • 84872286345 scopus 로고    scopus 로고
    • Effects of niacin on glucose levels, coronary stenosis progression, and clinical events in subjects with normal baseline glucose levels (<100 mg/dL): A combined analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Ath-erosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI during lipid-lowering (CPC) study
    • Phan BA, Muñoz L, Shadzi P, et al. Effects of niacin on glucose levels, coronary stenosis progression, and clinical events in subjects with normal baseline glucose levels (<100 mg/dL): a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Ath-erosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI during lipid-lowering (CPC) study. Am J Cardiol. 2013; 111(3): 352-355.
    • (2013) Am J Cardiol. , vol.111 , Issue.3 , pp. 352-355
    • Phan, B.A.1    Muñoz, L.2    Shadzi, P.3
  • 55
    • 84937858836 scopus 로고    scopus 로고
    • Liver fat, statin use, and incident diabetes: The Multi-Ethnic Study of Atherosclerosis
    • Shah RV, Allison MA, Lima JA, et al. Liver fat, statin use, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2015;242(1):211-217.
    • (2015) Atherosclerosis. , vol.242 , Issue.1 , pp. 211-217
    • Shah, R.V.1    Ma, A.2    Lima, J.A.3
  • 56
    • 84939969799 scopus 로고    scopus 로고
    • Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: A 6 year follow-up study of the METSIM cohort
    • Cederberg H, Stancáková A, Yaluri N, Modi S, Kuusisto J, Laakso M. Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort. Diabetologia. 2015;58(5): 1109-1117.
    • (2015) Diabetologia. , vol.58 , Issue.5 , pp. 1109-1117
    • Cederberg, H.1    Stancáková, A.2    Yaluri, N.3    Modi, S.4    Kuusisto, J.5    Laakso, M.6
  • 57
    • 84864861863 scopus 로고    scopus 로고
    • Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: An analysis from the JUPITER trial
    • Ridker PM, Pradhan A, Mac Fadyen JG, Libby P, Glynn RJ. Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial. Lancet. 2012;380(9841): 565-571.
    • (2012) Lancet. , vol.380 , Issue.9841 , pp. 565-571
    • Ridker, P.M.1    Pradhan, A.2    Mac Fadyen, J.G.3    Libby, P.4    Glynn, R.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.