Effects of niacin on glucose levels, coronary stenosis progression, and clinical events in subjects with normal baseline glucose levels (<100 mg/dl): A combined analysis of the familial atherosclerosis treatment study (FATS), HDL-atherosclerosis treatment study (HATS), armed forces regression study (AFREGS), and carotid plaque composition by MRI during lipid-lowering (CPC) study

American Journal of Cardiology

Volumn 111, Issue 3, 2013, Pages 352-355

  Phan, Binh An P ^a   Muñoz, Luis ^b   Shadzi, Pey ^b   Isquith, Daniel ^b   Triller, Michael ^b   Brown, B Greg ^b   Zhao, Xue Qiao ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; COLESEVELAM; COLESTIPOL; COLESTYRAMINE; GEMFIBROZIL; GLUCOSE; INSULIN; MEVINOLIN; NICOTINIC ACID; PLACEBO; SIMVASTATIN;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY OBSTRUCTION; DIABETES MELLITUS; DIET RESTRICTION; DISEASE COURSE; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE STUDY;

BLOOD GLUCOSE; CAROTID STENOSIS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CORONARY ANGIOGRAPHY; CORONARY STENOSIS; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOLIPIDEMIC AGENTS; LIPIDS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NIACIN; PLAQUE, ATHEROSCLEROTIC; TREATMENT OUTCOME;

EID: 84872286345     PISSN: 00029149     EISSN: 18791913     Source Type: Journal    
DOI: 10.1016/j.amjcard.2012.09.034     Document Type: Article

References (17)

1. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report Circulation 106 2002 3143 3421
2. Clofibrate and niacin in coronary heart disease JAMA 231 1975 360 381
3. G. Brown, J.J. Albers, L.D. Fisher, S.M. Schaefer, J.T. Lin, C. Kaplan, X.Q. Zhao, B.D. Bisson, V.F. Fitzpatrick, and H.T. Dodge Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B N Engl J Med 323 1990 1289 1298
4. A.J. Taylor, L.E. Sullenberger, H.J. Lee, J.K. Lee, and K.A. Grace Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins Circulation 110 2004 3512 3517
5. M.B. Elam, D.B. Hunninghake, K.B. Davis, R. Garg, C. Johnson, D. Egan, J.B. Kostis, D.S. Sheps, and E.A. Brinton Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: a randomized trial. Arterial Disease Multiple Intervention Trial JAMA 284 2000 1263 1270
6. S.M. Grundy, G.L. Vega, M.E. McGovern, B.R. Tulloch, D.M. Kendall, D. Fitz-Patrick, O.P. Ganda, R.S. Rosenson, J.B. Buse, D.D. Robertson, and J.P. Sheehan Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial Arch Intern Med 162 2002 1568 1576
7. B.G. Brown, X.Q. Zhao, A. Chait, L.D. Fisher, M.C. Cheung, J.S. Morse, A.A. Dowdy, E.K. Marino, E.L. Bolson, P. Alaupovic, J. Frohlich, and J.J. Albers Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease N Engl J Med 345 2001 1583 1592
8. E.J. Whitney, R.A. Krasuski, B.E. Personius, J.E. Michalek, A.M. Maranian, M.W. Kolasa, E. Monick, B.G. Brown, and A.M. Gotto Jr. A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events Ann Intern Med 142 2005 95 104
9. X.-Q. Zhao, L. Dong, T. Hatsukami, B.A. Phan, B. Chu, A. Moore, T. Lane, M.B. Neradilek, N. Polissar, D. Monick, C. Lee, H. Underhill, and C. Yuan MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time course JACC Cardiovasc Imaging 4 2011 977 986
10. R.A. DeFronzo Glucose intolerance and aging Diabetes Care 4 1981 493 501
11. R.I. Fink, O.G. Kolterman, J. Griffin, and J.M. Olefsky Mechanisms of insulin resistance in aging J Clin Invest 71 1983 1523 1535
12. A. Gille, E.T. Bodor, K. Ahmed, and S. Offermanns Nicotinic acid: pharmacological effects and mechanisms of action Annu Rev Pharmacol Toxicol 48 2008 79 106
13. D.K. McCulloch, S.E. Kahn, M.W. Schwartz, D.J. Koerker, and J.P. Palmer Effect of nicotinic acid-induced insulin resistance on pancreatic B cell function in normal and streptozocin-treated baboons J Clin Invest 87 1991 1395 1401
14. M. Alvarsson, and V. Grill Impact of nicotinic acid treatment on insulin secretion and insulin sensitivity in low and high insulin responders Scand J Clin Lab Invest 56 1996 563 570
15. F. Vittone, A. Chait, J.S. Morse, B. Fish, B.G. Brown, and X.-Q. Zhao Niacin plus simvastatin reduces coronary stenosis progression among patients with metabolic syndrome despite a modest increase in insulin resistance: a subgroup analysis of the HDL-Atherosclerosis Treatment Study (HATS) J Clin Lipidol 1 2007 203 210
16. P.L. Canner, C.D. Furberg, M.L. Terrin, and M.E. McGovern Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project) Am J Cardiol 95 2005 254 257
17. W.E. Boden, J.L. Probstfield, T. Anderson, B.R. Chaitman, P. Desvignes-Nickens, K. Koprowicz, R. McBride, K. Teo, and W. Weintraub Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy N Engl J Med 365 2011 2255 2267