Carvedilol improves inflammatory response, oxidative stress and fibrosis in the alcohol-induced liver injury in rats by regulating kuppfer cells and hepatic stellate cells

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  De Araújo, Raimundo Fernandes ^a   Garcia, Vinícius Barreto ^a   De Carvalho Leitão, Renata Ferreira ^b   De Castro Brito, Gerly Anne ^b   De Castro Miguel, Emilio ^b   Guedes, Paulo Marcos Matta ^a   De Araújo, Aurigena Antunes ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CARVEDILOL; CELL MARKER; CYCLOOXYGENASE 2; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; MALONALDEHYDE; MESSENGER RNA; MYELOPEROXIDASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROCOLLAGEN; PROCOLLAGEN TYPE I; PROCOLLAGEN TYPE III; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SUPEROXIDE DISMUTASE; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALCOHOL; BIOLOGICAL MARKER; CARBAZOLE DERIVATIVE; CYTOKINE; GLUTATHIONE PEROXIDASE; PEROXIDASE; PROPANOLAMINE DERIVATIVE;

ALCOHOL LIVER CIRRHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEGENERATION; DOSE RESPONSE; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; FATTY LIVER; GENE EXPRESSION; HEPATIC CORD DEGENERATION; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LIVER FIBROSIS; LIVER HOMOGENATE; LIVER LEVEL; LIVER NECROSIS; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WISTAR RAT; ANIMAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPATIC STELLATE CELL; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY;

ANIMALS; BIOMARKERS; CARBAZOLES; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOKINES; DISEASE MODELS, ANIMAL; ETHANOL; GENE EXPRESSION REGULATION; GLUTATHIONE PEROXIDASE; HEPATIC STELLATE CELLS; IMMUNOHISTOCHEMISTRY; KUPFFER CELLS; LIVER CIRRHOSIS; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; PEROXIDASE; PROPANOLAMINES; RATS; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 84960852307     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148868     Document Type: Article

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