Carvedilol Attenuates the Progression of Alcohol Fatty Liver Disease in Rats

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 9, 2012, Pages 1587-1599

  Liu, Jinyao ^a   Takase, Izumi ^a   Hakucho, Ayako ^a   Okamura, Nanako ^a   Fujimiya, Tatsuya ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Carvedilol; Ethanol; Gene expression; Hepatosteatosis

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; ALCOHOL; ALPHA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CARVEDILOL; COLLAGEN; FATTY ACID SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE;

ADRENERGIC SYSTEM; ALCOHOL BLOOD LEVEL; ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; LIVER FIBROSIS; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL; SYMPATHETIC TONE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BLOOD VESSELS; BLOTTING, WESTERN; CARBAZOLES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASE PROGRESSION; ETHANOL; FATTY LIVER, ALCOHOLIC; FLUORESCENT ANTIBODY TECHNIQUE; HEPATIC STELLATE CELLS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; MALE; METHOXYHYDROXYPHENYLGLYCOL; PROPANOLAMINES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; SYMPATHETIC NERVOUS SYSTEM; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84865975828     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01773.x     Document Type: Article

References (31)

1. Ajmo JM, Liang X, Rogers CQ, Pennock B, You M (2008) Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 295:G833-G842.
2. Chaldakov GN, Stankulov IS, Hristova M, Ghenev PI (2003) Adipobiology of disease: adipokines and adipokine-targeted pharmacology. Curr Pharm Des 9:1023-1031.
3. Endo M, Masaki T, Seike M, Yoshimatsu H (2007) TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Exp Biol Med (Maywood) 232:614-621.
4. Enomoto N, Takei Y, Hirose M, Konno A, Shibuya T, Matsuyama S, Suzuki S, Kitamura KI, Sato N (2003) Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptor-γ, pioglitazone. J Pharmacol Exp Ther 306:846-854.
5. Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275:2247-2250.
6. Fujimiya T, Liu J, Kojima H, Shirafuji S, Kimura H, Fujimiya M (2009) Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver. Am J Physiol Gastrointest Liver Physiol 297:G451-G460.
7. Grekin RJ, Dumont CJ, Vollmer AP, Watts SW, Webb RC (1997) Mechanisms in the pressor effects of hepatic portal venous fatty acid infusion. Am J Physiol 273:R324-R330.
8. Grunnet N, Kondrup J (1986) The effect of ethanol on the beta-oxidation of fatty acids. Alcohol Clin Exp Res 10:64S-68S.
9. Hsu CT (1995) The role of the autonomic nervous system in chemically-induced liver damage and repair-using the essential hypertensive animal model (SHR). J Auton Nerv Syst 51:135-142.
10. Ji C, Kaplowitz N (2003) Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124:1488-1499.
11. Katz AM, Messineo FC (1981) Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium. Circ Res 48:1-16.
12. Koppe SW, Sahai A, Malladi P, Whitington PF, Green RM (2004) Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. J Hepatol 41:592-598.
13. Lawler JF, Yin M, Diehl AM, Roberts E, Chatterjee S (1998) Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J Biol Chem 273:5053-5059.
14. Liu J, Fujimiya T (2008) Abrupt termination of an ethanol regimen enhances the arrhythmogenic effects of epinephrine in adult male rats. Alcohol Clin Exp Res 34:S45-S53.
15. Liu J, Yano M, Shimamoto A, Noma T, Matsuzaki M, Fujimiya T (2007) Chronic effects of ethanol on pharmacokinetics and left ventricular systolic function in rats. Alcohol Clin Exp Res 31:493-499.
16. Mailliard ME, Sorrell MF (2005) Alcoholic liver disease, in Harrison's Principles of Internal Medicine, Vol. 12 (Kasper DL, Braunwald E, Faucl AS, Hauser SL, Longo DL, Jameson JL eds), pp 1855-1858. MaGraw-Hill Medical Publishing Division, New York, NY.
17. Matsuoka M, Tsukamoto H (1990) Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology 11:599-605.
18. Oben JA, Diehl AM (2004) Sympathetic nervous system regulation of liver repair. Anat Rec A Discov Mol Cell Evol Biol 280:874-883.
19. Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Li Z, Torbenson M, Thomas SA, Diehl AM (2003) Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice. Biochem Biophys Res Commun 308:284-292.
20. Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Torbenson M, Smedh U, Moran TH, Li Z, Huang J, Thomas SA, Diehl AM (2004) Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut 53:438-445.
21. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA (2004) Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology 40:1106-1115.
22. Qin X, Xie X, Fan Y, Tian J, Guan Y, Wang X, Zhu Y, Wang N (2008) Peroxisome proliferator-activated receptor-δ induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology 48:432-441.
23. Ringseis R, Muschick A, Eder K (2007) Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver. J Nutr 137:77-83.
24. Salaspuro MP, Shaw S, Jayatilleke E, Ross WA, Lieber CS (1981) Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro. Hepatology 1:33-38.
25. Seth D, D'Souza El-Guindy NB, Apte M, Mari M, Dooley S, Neuman M, Haber PS, Kundu GC, Darwanto A, de Villiers WJ, Vonlaufen A, Xu Z, Phillips P, Yang S, Goldstein D, Pirola RM, Wilson JS, Moles A, Fernández A, Colell A, García-Ruiz C, Fernández-Checa JC, Meyer C, Meindl-Beinker NM (2010) Alcohol, signaling, and ECM turnover. Alcohol Clin Exp Res 34:4-18.
26. Seth D, Haber PS, Syn WK, Diehl AM, Day CP (2011) Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. J Gastroenterol Hepatol 26:1089-1105.
27. Siegmund SV, Brenner DA (2005) Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res 29(11 Suppl):102S-109S.
28. Sozio M, Crabb DW (2008) Alcohol and lipid metabolism. Am J Physiol Endocrinol Metab 295:E10-E16.
29. Stepniakowski KT, Goodfriend TL, Egan BM (1995) Fatty acids enhance vascular alpha-adrenergic sensitivity. Hypertension 25:774-778.
30. Voican CS, Perlemuter G, Naveau S (2011) Mechanisms of the inflammatory reaction implicated in alcoholic hepatitis: 2011 update. Clin Res Hepatol Gastroenterol 35:465-474.
31. You M, Fischer M, Deeg MA, Crabb DW (2002) Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277:29342-29347.