Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 389, Issue 4, 2016, Pages 393-402

  Ostadhadi, Sattar ^a,b,c   Kordjazy, Nastaran ^a,c   Haj Mirzaian, Arya ^a,c   Ameli, Sanaz ^a,c   Akhlaghipour, Golnoosh ^a,c   Dehpour, Ahmadreza ^a,b,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cyclic guanosine monophosphate (cGMP); Forced swimming test; Gabapentin; Mice; Nitric oxide

Indexed keywords

7 NITROINDAZOLE; AMINOGUANIDINE; ARGININE; CYCLIC GMP; GABAPENTIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SILDENAFIL; 4 AMINOBUTYRIC ACID; AMINE; ANTIDEPRESSANT AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; GUANYLATE CYCLASE; NEURONAL NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, MOUSE; PHOSPHODIESTERASE V INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FORCED SWIM TEST; HIPPOCAMPUS; IMMOBILITY; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; DEPRESSION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MOTOR ACTIVITY; PSYCHOLOGY; SWIMMING;

AMINES; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CYCLIC GMP; CYCLOHEXANECARBOXYLIC ACIDS; DEPRESSION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; GUANYLATE CYCLASE; HIPPOCAMPUS; MALE; MOTOR ACTIVITY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; PHOSPHODIESTERASE 5 INHIBITORS; SIGNAL TRANSDUCTION; SWIMMING;

EID: 84960803100     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1203-5     Document Type: Article

References (67)

1. Altshuler LL, Keck PE Jr, McElroy SL, Suppes T, Brown ES, Denicoff K, Frye M, Gitlin M, Hwang S, Goodman R (1999) Gabapentin in the acute treatment of refractory bipolar disorder. Bipolar Disord 1:61-65
2. Astaneh AN, Rezaei O (2012) Adjunctive treatment with gabapentin in bipolar patients during acute mania. Int J Psychiat Med 43:261-271
3. Bang S, Yoo S, Hwang SW (2009) Gabapentin attenuates the activation of transient receptor potential A1 by cinnamaldehyde. Exp Neurobiol 18:1-7
4. Beavo JA (1995) Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 75:725-748
5. Berton O, Nestler EJ (2006) New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7:137-151
6. Bortalanza LB, Ferreira J, Hess SC, Delle Monache F, Yunes RA, Calixto JB (2002) Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice. Eur J Pharmacol 453:203-208
7. Cheng J-K, Chiou L-C (2006) Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci 100:471-486
8. Cryan JF, Markou A, Lucki I (2002) Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23:238-245
9. Denninger JW, Marletta MA (1999) Guanylate cyclase and the NO/cGMP signaling pathway. BBABioenergetics 1411:334-350
10. Dhir A, Kulkarni S (2007) Involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice. Prog Neuro-Psychoph 31:921-925
11. Domek-Lopacinska K, Strosznajder J (2005) Cyclic GMP metabolism and its role in brain physiology. J Physio Pharmacol 56:15
12. Dubovsky S (1993) Calcium antagonists in manic-depressive illness. Neuropsychobiology 27:184-192
13. Eckeli AL, Dach F, Rodrigues ALS (2000) Acute treatments with GMP produce antidepressant-like effects in mice. Neuroreport 11:1839-1843
14. Erfurth A, Kammerer C, Grunze H, Normann C, Walden J (1998) An open label study of gabapentin in the treatment of acute mania. J Psychiat Res 32:261-264
15. Esplugues JV (2002) NO as a signalling molecule in the nervous system. Brit J Pharmacol 135:1079-1095
16. Frye MA, Ketter TA, Kimbrell TA, Dunn RT, Speer AM, Osuch EA, Luckenbaugh DA, Corá-Locatelli G, Leverich GS, Post RM (2000) A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharm 20:607-614
17. Furuta S, Shimizu T, Narita M, Matsumoto K, Kuzumaki N, Horie S, Suzuki T, Narita M (2009) Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. Neuroscience 164(3):1252-1262
18. Garthwaite J, Boulton C (1995) Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57:683-706
19. Ghaemi SN, Katzow JJ, Desai SP, Goodwin FK (1998) Gabapentin treatment of mood disorders: a preliminary study. J Clin Psychiat 59:426-429
20. Ghasemi M, Sadeghipour H, Mosleh A, Sadeghipour HR, Mani AR, Dehpour AR (2008) Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. Eur Neuropsychopharm 18:323-332
21. Goldlust A, Su T-Z, Welty DF, Taylor CP, Oxender DL (1995) Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA. Epilepsy Res 22:1-11
22. Granger DL, Taintor RR, Boockvar KS, Hibbs JB (1996) Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methods Enzymol 268:142-151
23. Gustafsson H, Flood K, Berge O-G, Brodin E, Olgart L, Stiller C-O (2003) Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. Expe Neurol 182:427-434
24. Haj-Mirzaian A, Ostadhadi S, Kordjazy N, Dehpour AR, Ejtemaei Mehr S (2014) Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test. Eur J Pharmacol 735:26-31
25. Haj-Mirzaian A, Kordjazy N, Haj-Mirzaian A, Ostadhadi S, Ghasemi M, Amiri S, Faizi M, Dehpour A (2015) Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests. Psychopharmacology 232:3551-3561
26. Hara K, Sata T (2007) Inhibitory effect of gabapentin on N-methyl-d-aspartate receptors expressed in Xenopus oocytes. Acta Anaesth Scand 51:122-128
27. Harvey BH, Oosthuizen F, Brand L, Wegener G, Stein DJ (2004) Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus. Psychopharmacology 175:494-502
28. Harkin A, Connor T, Walsh M, St John N, Kelly J (2003) Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors. Neuropharmacology 44:616-623
29. Harkin A, Connor TJ, Burns MP, Kelly JP (2004) Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test. Eur Neuropsychopharm 14:274-281
30. Harkin AJ, Bruce KH, Craft B, Paul IA (1999) Nitric oxide synthase inhibitors have antidepressant-like properties in mice: 1. acute treatments are active in the forced swim test. Eur J Pharmacol 372:207-213
31. Joca SRL, Guimarães FS (2006) Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects. Psychopharmacology 185:298-305
32. Kaster MP, Rosa AO, Santos AR, Rodrigues ALS (2005) Involvement of nitric oxide-cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test. Int J Neuropsychopharm 8:601-606
33. Kessler RC, Merikangas KR, Wang PS (2007) Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. Annu Rev Clin Psychol 3:137-158
34. Khan MI, Ostadhadi S, Zolfaghari S, Mehr SE, Hassanzadeh G, Dehpour A-R (2016) The involvement of NMDA receptor/NO/cGMP pathway in the antidepressant like effects of baclofen in mouse force swimming test. Neurosci Lett 62:52-61
35. Knoll J, Stegman K, Suppes T (1998) Clinical experience using gabapentin adjunctively in patients with a history of mania or hypomania. J Affect Disorders 49:229-233
36. Knowles RG, Moncada S (1994) Nitric oxide synthases in mammals. Biochem J 298:249
37. Kordjazy N, Haj-Mirzaian A, Amiri S, Ostadhadi S, Kordjazy M, Sharifzadeh M, Dehpour AR (2015) Elevated level of nitric oxide mediates the anti-depressant effect of rubidium chloride in mice. Eur J Pharmacol 762:411-418
38. Kordjazy N, Haj-Mirzaian A, Amiri S, Ostadhadi S, Amini-khoei H, Dehpour AR (2016) Involvement of N-methyl-daspartate receptors in the antidepressant-like effect of 5-hydroxytryptamine 3 antagonists in mouse forced swimming test and tail suspension test. Pharmacol Biochem Be 141:1-9
39. Marais E, Klugbauer N, Hofmann F (2001) Calcium channel α2δ subunits - structure and gabapentin binding. Mol Pharmacol 59:1243-1248
40. McElroy SL, Soutullo CA, Keck PE Jr, Kmetz GF (1997) A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder. Ann Clin Psychiatry 9:99-103
41. McLeod T, Lopez-Figueroa A, Lopez-Figueroa M (2000) Nitric oxide, stress, and depression. Psychopharmacol Bull 35:24-41
42. Miranda HF, Sierralta F, Lux S, Troncoso R, Ciudad N, Zepeda R, Zanetta P, Noriega V, Prieto JC (2015) Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice. Pharmacol Rep 67:399-403
43. Nanri K, Montécot C, Springhetti V, Seylaz J, Pinard E (1998) The selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats. Stroke 29:1248-1254
44. Nemeroff CB, Owens MJ (2002) Treatment of mood disorders. Nat Neurosci 5:1068-1070
45. Oka M, Itoh Y, Wada M, Yamamoto A, Fujita T (2003) Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex. Pharmaceut Res 20:897-899
46. Ostadhadi S, Haj-Mirzaian A, Nikoui V, Kordjazy N, Dehpour AR (2015) Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice. Clin Exp Pharmacol P. doi: 10.1111/1440-1681.12518
47. Pande AC, Davidson JR, Jefferson JW, Janney CA, Katzelnick DJ, Weisler RH, Greist JH, Sutherland SM (1999) Treatment of social phobia with gabapentin: a placebo-controlled study. J Clini Psychopharm 19:341-348
48. Pande AC, Pollack MH, Crockatt J, Greiner M, Chouinard G, Lydiard RB, Taylor CB, Dager SR, Shiovitz T (2000) Placebo-controlled study of gabapentin treatment of panic disorder. J Clini Psychopharm 20:467-471
49. Porsolt R, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacod T 229:327-336
50. Rajasekaran K, Jayakumar R, Venkatachalam K (2003) Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs. Brain Res 979:85-97
51. Rao ML, Clarenbach P, Vahlensieck M, Krätzschmar S (1988) Gabapentin augments whole blood serotonin in healthy young men. J Neural Transm 73:129-134
52. Schulz R, Drayer RA, Rollman BL (2002) Depression as a risk factor for non-suicide mortality in the elderly. Biol Psychiatry 52:205-225
53. Singh L, Field M, Ferris P, Hunter J, Oles R, Williams R, Woodruff G (1996) The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine. Psychopharmacology 127:1-9
54. Southam E, Garthwaite J (1993) The nitric oxide-cyclic GMP signalling pathway in rat brain. Neuropharmacology 32:1267-1277
55. Spiacci A Jr, Kanamaru F, Guimaraes F (2008) Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression. Pharmacol Biochem Behav 88:247-255
56. Stanton S, Keck P Jr, McElroy S (1997) Treatment of acute mania with gabapentin. Am J Psychiatry 154:287
57. Stefani A, Spadoni F, Bernardi G (1998) Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology 37:83-91
58. Stefani A, Spadoni F, Giacomini P, Lavaroni F, Bernardi G (2001) The effects of gabapentin on different ligand-and voltage-gated currents in isolated cortical neurons. Epilepsy Res 43:239-248
59. Suman-Chauhan N, Webdale L, Hill DR, Woodruff GN (1993) Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies. Europ J Pharmacol: Molec Pharmacol 244:293-301
60. Sutton K, Martin D, Pinnock R, Lee K, Scott R (2002) Gabapentin inhibits high'threshold calcium channel currents in cultured rat dorsal root ganglion neurones. Br J Pharmacol 135:257-265
61. Taylor CP (1996) Mechanisms of action of gabapentin. Rev Neurol 153:S39-45
62. Vieta E, Martinez-Aran A, Nieto E, Colom F, Reinares M, Benabarre A, Gasto C (2000) Adjunctive gabapentin treatment of bipolar disorder. Europ Psychiatr 15:433-437
63. Volke V, Wegener G, Bourin M, Vasar E (2003) Antidepressant-and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res 140:141-147
64. Wang PW, Santosa C, Schumacher M, Winsberg ME, Strong C, Ketter TA (2002) Gabapentin augmentation therapy in bipolar depression. Bipolar Disord 4:296-301
65. Yasmin S, Carpenter LL, Leon Z, Siniscalchi JM, Price LH (2001) Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review. J Affect Disord 63:243-247
66. Yildiz F, Erden BF, Ulak G, Utkan T, Gacar N (2000) Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats. Psychopharmacology 149:41-44
67. Zomkowski AD, Engel D, Gabilan NH, Rodrigues ALS (2010) Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test. Eur Neuropsychopharmacol 20:793-801