Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex

Pharmaceutical Research

Volumn 20, Issue 6, 2003, Pages 897-899

  Oka, Michiko ^a   Itoh, Yoshinori ^b   Wada, Miyuki ^a   Yamamoto, Akira ^a   Fujita, Takuya ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

agatoxin IVA; conotoxin GVIA; Ca2+ channels; cGMP; Gabapentin; Mouse cerebral cortex; Nitric oxide synthesis; Primary neuronal culture

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CYCLIC GMP; GABAPENTIN; MESSENGER RNA; NIFEDIPINE; NITRIC OXIDE SYNTHASE; OMEGA AGATOXIN VIA; OMEGA CONOTOXIN GVIA; POTASSIUM ION; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FETUS; GENE EXPRESSION; MOUSE; NERVE CELL CULTURE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL STIMULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETIC ACIDS; AMINES; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, P-TYPE; CALCIUM CHANNELS, Q-TYPE; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC GMP; CYCLOHEXANECARBOXYLIC ACIDS; FEMALE; GAMMA-AMINOBUTYRIC ACID; MICE; MOLECULAR SEQUENCE DATA; NEURONS; NIFEDIPINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OMEGA-CONOTOXIN GVIA; POTASSIUM CHLORIDE; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0037677569     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024078704020     Document Type: Article

References (15)

1. A. Caraceni, E. Zecca, C. Martini, and F. De Conno. Gabapentin as an adjuvant to opioid analgesia for neuropathic cancer pain. J. Pain Symptom Manage. 17:441-445 (1999).
2. R. E. Ramsay. Clinical efficacy and safety of gabapentin. Neurology 44:S23-S30 (1994).
3. 2δ subunit of a calcium channel. J. Biol. Chem. 271:5768-5776 (1996).
4. K. G. Sutton, D. J. Martin, R. D. Pinnock, K. Lee, and R. H. Scott. Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurons. Br. J. Pharmacol. 135:257-265 (2002).
5. A. Stefani, F. Spadoni, and G. Bernardi. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology 37:83-91 (1998).
6. 2+ channel activation and resultant nitric oxide synthesis in glutamate-mediated hypoxic injury in rat cerebrocortical slices. Life Sci. 67:2331-2343 (2000).
7. 2+ channels involving depolarization-stimulated nitric oxide synthase activity in primary neuronal culture. J. Neurochem. 72: 1315-1322 (1999).
8. 2δ subunit. Am. J. Physiol. 274:C1324-C1331 (1998).
9. 2δ for gabapentin binding, Biochem. J. 342:313-320 (1999).
10. 2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br. J. Pharmacol. 130:900-906 (2000).
11. A. B. Malmberg and T. L. Yaksh. Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception. J. Neurosci. 14: 4882-4890 (1994).
12. 2+ influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology 42:229-236 (2002).
13. +-induced synaptosomal calcium influx by gabapentin. Brain Res. 875:157-159 (2000).
14. H. F. Miranda, D. Bustamante, K. Veronica, P. Teresa, S. Hernan, C. Paeile, E. Fernandez, and G. Pinardi. Anti-nociceptive effects of calcium channel blockers. Eur. J. Pharmacol. 217:137-141 (1992).
15. Y. Takagaki, Y. Itoh, Y, Aoki, Y. Ukai, Y. Yoshikuni, and K. Kimura. Inhibition of ischemia-induced fodrin breakdown by a novel phenylpyrimidine derivative NS-7: an implication for its neuroprotective action in rats with middle cerebral artery occlusion. J. Neurochem. 68:2507-2513 (1997).