The selective inhibitor of neuronal nitric oxide synthase, 7- nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats

Stroke

Volumn 29, Issue 6, 1998, Pages 1248-1254

  Nanri, Kazunori ^b   Montécot, Céline ^b   Springhetti, Véronique ^b   Seylaz, Jacques ^b   Pinard, Elisabeth ^a  

^a UFR Lariboisiere S Louis Paris VII   (France)

^b NONE

Author keywords

Cerebral ischemia; Hippocampus; Neuroprotection; Nitric oxide

Indexed keywords

7 NITROINDAZOLE; ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG MIXTURE; FOREBRAIN; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

EID: 0344813701     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.29.6.1248     Document Type: Article

References (53)

1. Malinski T, Bailey F, Zhang ZG, Chopp M. Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1993;13:355-358.
2. Kader A, Frazzini VI, Solomon RA, Trifiletti RR. Nitric oxide production during focal cerebral ischemia. Stroke. 1993;24:1709-1716.
3. Tominaga T, Sato S, Ohnishi T, Ohnishi ST. Potentiation of nitric oxide formation following bilateral carotid occlusion and focal cerebral ischemia in the rat: in vivo detection of the nitric oxide radical by electron paramagnetic resonance spin trapping. Brain Res. 1993;614:342-346.
4. Tominaga T, Sato S, Ohnishi T, Ohnishi ST. Electron paramagnetic resonance (EPR) detection of nitric oxide produced during forebrain ischemia of the rat. J Cereb Blood Flow Metab. 1994;14:715-722.
5. Lin SZ, Chiou AL, Wang Y. Ketamine antagonizes nitric oxide release from cerebral cortex after middle cerebral artery ligation in rats. Stroke. 1996;27:747-752.
6. Iadecola C. Dark and bright sides of nitric oxide in ischemic brain injury. Trends Neurosci. 1997;20:132-139.
7. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab. 1994;14:175-192.
8. Samdani AF, Dawson TM, Dawson VL. Nitric oxide synthase in models of focal ischemia. Stroke. 1997;28:1283-1288.
9. Moncada C, Lekieffre D, Arvin B, Meldrum B. Effect of NO synthase inhibition on NMDA- and ischemia-induced hippocampal lesions. Neuroreport. 1992;3:530-532.
10. Buchan AM, Gertler SZ, Huang ZG, Li H, Chaundy KE, Xue D. Failure to prevent selective CA1 neuronal death and reduce cortical infarction following cerebral ischemia with inhibition of nitric oxide synthase. Neuroscience. 1994;61:1-11.
11. G-Nitro-L-arginine protects against ischaerma-induced increases in nitric oxide and hippocampal neurodegeneration in the gerbil. Eur J Pharmacol. 1994;260: 291-200.
12. G-Nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils. Neurosci Lett. 1992;146:139-142.
13. Sancesario G, Ianonne M, Morello M, Nistico G, Bernardi G. Nitric oxide inhibition aggravates ischemic damage of hippocampal but not of NADPH neurons in gerbils. Stroke. 1994;25:436-444.
14. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 1994;265:1883-1885.
15. Panahian N, Yoshida T, Huang PL, Heddley-Whyte ET, Dalkara T, Fishman MC, Moskowitz MA. Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase. Neuroscience. 1996;72:343-354.
16. Hara H, Huang PL, Panahian N, Fishman MC, Moskowitz MA. Reduced brain oedema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J Cereb Blood Flow Metab. 1996;16:605-611.
17. Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovasc Brain Metab Rev. 1991;3:213-245.
18. East SJ, Garthwaite J. NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci Lett. 1991;123:17-19.
19. Valtschanoff JG, Weinberg RJ, Kharazia VN, Nakane M, Schmidt HHHW. Neurons in rat hippocampus that synthesize nitric oxide. J Comp Neurol 1993;331:111-121.
20. Vincent SR, Hope BT. Neurons that say NO. Trends Neurosci. 1992;15: 108-113.
21. Wendland B, Schweizer FE, Ryan TA, Nakane M, Murad F, Scheller RH, Tsien RW. Existence of nitric oxide synthase in rat hippocampal pyramidal cells. Proc Natl Acad Sci USA. 1994;91:2151-2155.
22. 1 hippocampal neurons and other central nervous system neurons. Neuroscience. 1994;63:679-689.
23. Dawson VL, Dawson TM, London ED, Bredt DS. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A. 1991;88:6368-6371.
24. Dawson VL, Kizushi VM, Huang PL, Snyder SH, Dawson TM. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J Neurosci. 1996;16:2479-2487.
25. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad and the ugly. Am J Physiol. 1996;271:C1424-C1437.
26. 1 region of rat hippocampal slices. Neurosci Lett. 1996;210:157-160.
27. Garthwaite G, Garthwaite J. Nitric oxide does not mediate acute glutamate neurotoxicity, nor is it neuroprotective, in rat brain slices. Neuropharmacology. 1994;33:1431-1438.
28. Moore PK, Bland-Ward PA. 7-Nitroindazole: an inhibitor of nitric oxide synthase. In: Abelson JN, Simon MI, eds. Methods in Enzymology. San Diego, Calif: Academic Press; 1996;268:393-398.
29. Babbedge RC, Bland-Ward PA, Hart SL, Moore PK. Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br J Pharmacol. 1993;110:225-228.
30. Schulz JB, Matthews RT, Jenkins BG, Ferrante RJ, Siwek D, Henshaw DR, Cipolloni PB, Mecocci P, Kowall NW, Rosen BR, Beal MF. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J Neurosci. 1995;15:8419-8429.
31. Yoshida T, Limmroth V, Irikura K, Moskowitz MA. The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. J Cereb Blood Flow Metab. 1994; 14:924-929.
32. O'Neill MJ, Hicks C, Ward M. Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia. Eur J Pharmacol. 1996;310:115-122.
33. Busto R, Dietrich WD, Globus MYT, Ginsberg MD. Postischemic moderate hypothermia inhibits CAl hippocampal ischemic neuronal injury. Neurosci Lett. 1989;101:299-304.
34. Coimbra C, Wieloch T. Hypothermia ameliorates neuronal survival when induced 2 hours after ischaemia in the rat. Acta Physiol Scand. 1992;146: 543-544.
35. Dietrich WD, Busto R, Alonso O, Globus MYT, Ginsberg MD. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab. 1993;13:541-549.
36. Nurse S, Corbett D. Neuroprotection after several days of mild, drug-induced hypothermia. J Cereb Blood Flow Metab. 1996;16: 474-480.
37. Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke. 1979;10:267-271.
38. Crain BJ, Westerkam WD, Harrison AH, Nadler JV. Selective neuronal death after transient ischemia in the mongolian gerbil: a silver impregnation study. Neuroscience. 1988;27:387-402.
39. Moore PK, Wallace P, Gaffen Z, Hart SL, Babbedge RC. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993;110:219-224.
40. Mackenzie GM, Rose S, Bland-Ward PA, Moore PK, Jenner P, Marsden CD. Time course of inhibition of brain nitric oxide synthase by 7-nitro indazole. Neuroreport. 1994;5:1993-1996.
41. Momécot C, Rondi-Reig L, Springhetti V, Seylaz J, Pinard E. Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures. Neuroscience. 1998;84:791-800.
42. Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA. 1990;87:682-685.
43. Kelly PAT, Ritchie IM, Arbuthnott GW. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: effects upon local cerebral blood flow and glucose use in the rat. J Cereb Blood Flow Metab. 1995;15: 766-773.
44. Montécot C, Borredon J, Seylaz J, Pinard E. Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate. J Cereb Blood Flow Metab. 1997;7:94-99.
45. Dinerman JL, Dawson TM, Schell MJ, Snowman A, Snyder SH. Endothelial nitric oxide localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc Natl Acad Sci USA. 1994; 91:4214-4218.
46. Kirsch JR, Bhardwaj A, Martin LJ, Hanley DF, Traystman RJ. Neither L-arginine nor L-NAME affects neurological outcome after global ischemia in cats. Stroke. 1997;28:2259-2265.
47. Klatt P, Schmid M, Leopold E, Schmidt K, Werner ER, Mayer B. The pteridine binding site of brain nitric oxide synthase. J Biol Chem. 1994; 269:13861-13866.
48. Di Monte DA, Royland JE, Jakowec MW, Langston JW. Role of nitric oxide in methamphetamine neurotoxicity: protection by 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase. J Neurochem. 1996;67: 2443-2450.
49. Itzhak Y, Ali SF. The neuronal nitric oxide synthase inhibitor, 7-nitroindazole, protects against methamphetamine-induced neurotoxicity in vivo. J Neurochem. 1996;67:1770-1773.
50. Schottler F, Collins JL, Fergus A, Okonkwo D, Kassel NF, Lee KS. Structural interactions between NOS-positive neurons and blood vessels in the hippocampus. Neuroreport. 1996;7:966-968.
51. Wang Q, Pelligrino DA, Baughman VL, Koenig HM, Albrecht RF. The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J Cereb Blood Flow Metab. 1995;15:774-778.
52. Cholet N, Bonvento G, Seylaz J. Effect of neuronal NO synthase inhibition on the cerebral vasodilatory response to somatosensory stimulation. Brain Res. 1996;708:197-200.
53. Siesjö BK, Agardh CD, Bengtsson F. Free radicals and brain damage: a speculative synthesis. Cerebrovasc Brain Metab Rev. 1989;1: 165-211.