Evaluation of the PIGRET assay in rats by single oral dosing with azidothymidine

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 811, Issue , 2016, Pages 65-69

  Sanada, Hisakazu ^a   Ohsumi, Tomoka ^a   Koyama, Naomi ^a   Miyashita, Taishi ^a   Hashimoto, Kazuto ^a  

^a KAKEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Azidothymidine; PIGRET assay; RBC Pig a assay

Indexed keywords

PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL GLYCAN CLASS A; UNCLASSIFIED DRUG; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MEMBRANE PROTEIN; MUTAGENIC AGENT; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ASSAY; GENE DELETION; GENE MUTATION; MALE; MUTATION RATE; NONHUMAN; PIGRET ASSAY; PRIORITY JOURNAL; RAT; RED BLOOD CELL PHOSPHATIDYLINOSITOL GLYCAN CLASS A ASSAY; SINGLE DRUG DOSE; WEIGHT GAIN; ANIMAL; DRUG EFFECTS; GENETICS; MUTAGEN TESTING; ORAL DRUG ADMINISTRATION; PROCEDURES; RETICULOCYTE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; MEMBRANE PROTEINS; MUTAGENICITY TESTS; MUTAGENS; RATS; RETICULOCYTES; ZIDOVUDINE;

EID: 84960540553     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2016.02.005     Document Type: Article

References (18)

1. [1] Miura, D., Dobrovolsky, V.N., Kasahara, Y., Katsuura, Y., Heflich, R.H., Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. Environ. Mol. Mutagen. 49 (2008), 614–621.
2. [2] Kimoto, T., Chikura, S., Suzuki, K., Kobayashi, X., Itano, Y., Horibata, K., Honma, M., Dobrovolsky, V.N., Heflich, R.H., Miura, D., Kasahara, Y., Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes. Environ. Mol. Mutagen. 52 (2011), 774–783.
3. [3] Low, M.G., The glycosyl-phosphatidylinositol anchor of membrane proteins. Biochim. Biophys. Acta. 988 (1989), 427–454.
4. [4] Cross, G.A., Glycolipid anchoring of plasma membrane proteins. Annu. Rev. Cell Biol. 6 (1990), 1–39.
5. [5] Gollapudi, B.B., Lynch, A.M., Heflich, R.H., Dertinger, S.D., Dobrovolsky, V.N., Froetschl, R., Horibata, K., Kenyon, M.O., Kimoto, T., Lovell, D.P., Stankowski, L.F. Jr., White, P.A., Witt, K.L., Tanir, J.Y., The in vivo Pig-a assay: a report of the international workshop on genotoxicity testing (IWGT) workgroup. Mutat. Res. 783 (2015), 23–35.
6. [6] Kimoto, T., Horibata, K., Chikura, S., Hashimoto, K., Itoh, S., Sanada, H., Muto, S., Uno, Y., Yamada, M., Honma, M., Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody. Mutat. Res. 755 (2013), 126–134.
7. [7] Miura, D., The in vivo pig-a gene mutation assay. Genes Environ. 36 (2014), 169–173.
8. [8] IARC. Zidovudine (AZT). IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, 76, 2000. 73–127.
9. [9] Poirier, M.C., Olivero, O.A., Walker, D.M., Walker, W.E., Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs. Toxicol. Appl. Pharmacol. 199 (2004), 151–161.
10. [10] Zeller, A., Koenig, J., Schmitt, G., Singer, T., Guérard, M., Genotoxicity profile of azidothymidine in vitro. Toxicol. Sci. 135 (2013), 317–327.
11. [11] Sussman, H.E., Olivero, O.A., Meng, Q., Pietras, S.M., Poirier, M.C., O'Neill, J.P., Finette, B.A., Bauer, M.J., Walker, V.E., Genotoxicity of 3′-azido-3′-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT. Mutat. Res. 429 (1999), 249–259.
12. [12] Meng, Q., Su, T., Olivero, O.A., Poirier, M.C., Shi, X., Ding, X., Walker, V.E., Relationships between DNA incorporation mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3′-azido-3′-deoxythymidine. Toxicol. Sci. 54 (2000), 322–329.
13. [13] Guérard, M., Koenig, J., Festag, M., Dertinger, S.D., Singer, T., Schmitt, G., Zeller, A., Assessment of the genotoxic potential of azidothymidine in the comet micronucleus, and Pig-a assay. Toxicol. Sci. 135 (2013), 309–316.
14. [14] Ayers, K.M., Clive, D., Tucker, W.E. Jr., Hajian, G., de Miranda, P., Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats. Fundam. Appl. Toxicol. 32 (1996), 148–158.
15. [15] Kimoto, T., et al. The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: summary of the MMS/JEMS-collaborative study across 16 laboratoriesusing 24 chemicals. Mutat. Res. 811 (2016), 3–15.
16. [16] Busidan, Y., Shi, X., Dow-Edwards, D.L., AZT distribution in the fetal and postnatal rat central nervous system. J. Pharm. Sci. 90 (2001), 1964–1971.
17. +/− mice treated neonatally with zidovudine and lamivudine. Carcinogenesis 23 (2002), 1427–1432.
18. [18] Von Tungeln, L.S., Dobrovolsky, V.N., Bishop, M.E., Shaddock, J.G., Heflich, R.H., Beland, F.A., Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine. Mutagenesis 19 (2004), 307–311.