Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: Relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 429, Issue 2, 1999, Pages 249-259

  Sussman, Hillary E ^a,b   Olivero, Ofelia A ^c   Meng, Quanxin ^a   Pietras, Sara M ^c   Poirier, Miriam C ^c   O'Neill, J Patrick ^d   Finette, Barry A ^d   Bauer, Michael J ^a,b   Walker, Vernon E ^a,b  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c Lab Cell Carcinogenesis Tum Prom   (United States)

^d UNIVERSITY OF VERMONT   (United States)

Author keywords

AZT; HPRT; Mutagenicity; Mutational spectrum; TK6 cells

Indexed keywords

3' AMINO 3' DEOXYTHYMIDINE; CELL DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; ZIDOVUDINE;

ARTICLE; CELL CLONING; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; EXON; GENE DELETION; GENE LOCUS; GENE MUTATION; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MUTATION RATE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ANTI-HIV AGENTS; CELL LINE; CELL SURVIVAL; DIDEOXYNUCLEOSIDES; GENE DELETION; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENICITY TESTS; POINT MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE DELETION; TIME FACTORS; ZIDOVUDINE;

MAMMALIA;

EID: 0032830814     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00111-6     Document Type: Article

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