Design and evaluation of novel glutaminase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 8, 2016, Pages 1819-1839

  McDermott, Lee A ^a   Iyer, Prema ^a   Vernetti, Larry ^a   Rimer, Shawn ^a   Sun, Jingran ^a   Boby, Melissa ^a   Yang, Tianyi ^a   Fioravanti, Michael ^a   O'Neill, Jason ^a   Wang, Liwei ^a   Drakes, Dylan ^a   Katt, William ^b   Huang, Qingqiu ^b   Cerione, Richard ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

BPTES; CB 839; GAC; Novel glutaminase inhibitors

Indexed keywords

BIS 2 (5 PHENYLACETAMIDO 1,3,4 THIADIAZOL YL)ETHYL SULFIDE; CB 839; GLUTAMINASE ISOFORM C INHIBITOR; HYDROLASE INHIBITOR; UNCLASSIFIED DRUG; BENZENEACETAMIDE DERIVATIVE; BIS-2-(5-PHENYLACETAMIDO-1,2,4-THIADIAZOL-2-YL)ETHYL SULFIDE; CB-839; ENZYME INHIBITOR; GLUTAMINASE; SULFIDE; THIADIAZOLE DERIVATIVE;

ARTICLE; BREAST CANCER CELL LINE; CHEMICAL PARAMETERS; CHIRALITY; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG STRUCTURE; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIGAND EFFICIENCY; LIPOPHILIC EFFICIENCY; MDA MB 231 CELL LINE; METABOLIC STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; X RAY ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; LIVER MICROSOME; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

BENZENEACETAMIDES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; GLUTAMINASE; HUMANS; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; THIADIAZOLES;

EID: 84960539433     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.03.009     Document Type: Article

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