Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns

Clinical Nutrition

Volumn 35, Issue 2, 2016, Pages 388-393

  Yuan, Li Jia ^a,c   Qin, Yu ^a   Wang, Lin ^b   Zeng, Yuan ^a   Chang, Hui ^a   Wang, Jian ^b   Wang, Bin ^a   Wan, Jing ^a   Chen, Shi Hui ^a   Zhang, Qian Yong ^a   Zhu, Jun Dong ^a   Zhou, Yong ^a   Mi, Man Tian ^a  

^a Institute of Combined Injury   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c No 44 Hospital of the People's Liberation Army   (China)

Author keywords

Calcitonin gene related peptide; Capsaicin; Gestational diabetes mellitus; Glucose metabolism; Large for gestational age newborns

Indexed keywords

APOLIPOPROTEIN B; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CHOLESTEROL; GLUCOSE; INSULIN; LIPID; PLACEBO; TRIACYLGLYCEROL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE BLOOD LEVEL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT MEDICINAL PRODUCT;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DEFECATION; DIARRHEA; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; DYSLIPIDEMIA; FEMALE; FETUS; GLUCOSE BLOOD LEVEL; HEAT SENSATION; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INCIDENCE; INSULIN BLOOD LEVEL; KIDNEY FUNCTION; LARGE FOR GESTATIONAL AGE; LIPID BLOOD LEVEL; LIPID METABOLISM; LIVER FUNCTION; NEWBORN; PEPPER; POSTPRANDIAL STATE; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TRIACYLGLYCEROL BLOOD LEVEL; URTICARIA; BLOOD; BODY MASS; CHEMISTRY; DIABETES, GESTATIONAL; DIETARY SUPPLEMENT; DYSLIPIDEMIAS; FETAL MACROSOMIA; HYPERINSULINISM; INSULIN RESISTANCE; LIFESTYLE; METABOLISM; PHYTOTHERAPY; PREGNANCY; PREGNANCY COMPLICATIONS;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BODY MASS INDEX; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CAPSICUM; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIABETES, GESTATIONAL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DYSLIPIDEMIAS; FEMALE; FETAL MACROSOMIA; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; INCIDENCE; INSULIN; INSULIN RESISTANCE; LIFE STYLE; PHYTOTHERAPY; PLANT PREPARATIONS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; TRIGLYCERIDES;

EID: 84960487758     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2015.02.011     Document Type: Article

References (28)

1. Metzger B.E., Gabbe S.G., Persson B., Buchanan T.A., Catalano P.A., Damm P., et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010, 33:676-682.
2. Metzger B.E., Lowe L.P., Dyer A.R., Trimble E.R., Chaovarindr U., Coustan D.R., et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008, 358:1991-2002.
3. Crowther C.A., Hiller J.E., Moss J.R., McPhee A.J., Jeffries W.S., Robinson J.S. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005, 352:2477-2486.
4. Pridjian G., Benjamin T.D. Update on gestational diabetes. Obstet Gynecol Clin North Am 2010, 37:255-267.
5. Alwan N., Tuffnell D.J., West J. Treatments for gestational diabetes. Cochrane Database Syst Rev 2009, (3). CD003395.
6. Hellmuth E., Damm P., Molsted-Pedersen L. Oral hypoglycaemic agents in 118 diabetic pregnancies. Diabet Med 2000, 17:507-511.
7. Tieu J., Coat S., Hague W., Middleton P. Oral anti-diabetic agents for women with pre-existing diabetes mellitus/impaired glucose tolerance or previous gestational diabetes mellitus. Cochrane Database Syst Rev 2010, (10). CD007724.
8. Luoto R., Kinnunen T.I., Aittasalo M., Kolu P., Raitanen J., Ojala K., et al. Primary prevention of gestational diabetes mellitus and large-for-gestational-age newborns by lifestyle counseling: a cluster-randomized controlled trial. PLoS Med 2011, 8. e1001036.
9. Zhu Z., Luo Z., Ma S., Liu D. TRP channels and their implications in metabolic diseases. Pflugers Arch 2011, 461:211-223.
10. Ahuja K.D., Robertson I.K., Geraghty D.P., Ball M.J. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am J Clin Nutr 2006, 84:63-69.
11. Ahuja K.D., Robertson I.K., Geraghty D.P., Ball M.J. The effect of 4-week chilli supplementation on metabolic and arterial function in humans. Eur J Clin Nutr 2007, 61:326-333.
12. Hoover D.B. Effects of capsaicin on release of substance P-like immunoreactivity and physiological parameters in isolated perfused guinea-pig heart. Eur J Pharmacol 1987, 141:489-492.
13. Chaiyasit K., Khovidhunkit W., Wittayalertpanya S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thai 2009, 92:108-113.
14. Domotor A., Szolcsanyi J., Mozsik G. Capsaicin and glucose absorption and utilization in healthy human subjects. Eur J Pharmacol 2006, 534:280-283.
15. Ahuja K.D., Ball M.J. Effects of daily ingestion of chilli on serum lipoprotein oxidation in adult men and women. Br J Nutr 2006, 96:239-242.
16. Lopez-Carrillo L., Lopez-Cervantes M., Robles-Diaz G., Ramirez-Espitia A., Mohar-Betancourt A., Meneses-Garcia A., et al. Capsaicin consumption, Helicobacter pylori positivity and gastric cancer in Mexico. Int J Cancer 2003, 106:277-282.
17. Ludy M.J., Mattes R.D. The effects of hedonically acceptable red pepper doses on thermogenesis and appetite. Physiol Behav 2011, 102:251-258.
18. Pellicer F., Picazo O., Leon-Olea M. Effect of red peppers (Capsicum frutescens) intake during gestation on thermonociceptive response of rat offspring. Behav Brain Res 2001, 119:179-183.
19. Landon M.B., Spong C.Y., Thom E., Carpenter M.W., Ramin S.M., Casey B., et al. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med 2009, 361:1339-1348.
20. Wang L.H., Zhou S.X., Li R.C., Zheng L.R., Zhu J.H., Hu S.J., et al. Serum levels of calcitonin gene-related peptide and substance P are decreased in patients with diabetes mellitus and coronary artery disease. J Int Med Res 2012, 40:134-140.
21. Molina J.M., Cooper G.J., Leighton B., Olefsky J.M. Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide. Diabetes 1990, 39:260-265.
22. Choi S.B., Frontoni S., Rossetti L. Mechanism by which calcitonin gene-related peptide antagonizes insulin action in vivo. Am J Physiol 1991, 260:E321-E325.
23. Riera C.E., Huising M.O., Follett P., Leblanc M., Halloran J., Van Andel R., et al. TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. Cell 2014, 157:1023-1036.
24. Walker C.S., Li X., Whiting L., Glyn-Jones S., Zhang S., Hickey A.J., et al. Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity. Endocrinology 2010, 151:4257-4269.
25. Gram D.X., Ahren B., Nagy I., Olsen U.B., Brand C.L., Sundler F., et al. Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. Eur J Neurosci 2007, 25:213-223.
26. Steculorum S.M., Bruning J.C. Die another day: a painless path to longevity. Cell 2014, 157:1004-1006.
27. Baboota R.K., Murtaza N., Jagtap S., Singh D.P., Karmase A., Kaur J., et al. Capsaicin-induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice. J Nutr Biochem 2014, 25:893-902.
28. Naseer M.I., Bibi F., Alqahtani M.H., Chaudhary A.G., Azhar E.I., Kamal M.A., et al. Role of gut microbiota in obesity, type 2 diabetes and Alzheimer's disease. CNS Neurol Disord Drug Targets 2014, 13:305-311.