Capsaicin and glucose absorption and utilization in healthy human subjects

European Journal of Pharmacology

Volumn 534, Issue 1-3, 2006, Pages 280-283

  Dömötör, András ^a   Szolcsányi, János ^a   Mózsik, Gyula ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Capsaicin; Capsaicin induced glucagon mobilization; Glucagon mobilization; Glucose absorption test; Human healthy subjects

Indexed keywords

C PEPTIDE; CAPSAICIN;

ARTICLE; DRUG EFFECT; GLUCAGON BLOOD LEVEL; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLUCOSE UTILIZATION; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; NORMAL HUMAN; PRIORITY JOURNAL;

CAPSAICIN; GLUCAGON; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INTESTINAL ABSORPTION; MIDDLE AGED;

EID: 33644888781     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.01.017     Document Type: Article

References (15)

1. M.J. Caterina, M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 1997 816 824
2. 13C labeled octanoid acid breath test J. Physiol. (Paris) 93 1999 445 460
3. D.X. Gram, A.J. Hansen, C.F. Deacon, C.L. Brand, U. Ribel, M. Wilken, R.D. Carr, O. Svendsen, and B. Ahrén Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidly peptidase IV Eur. J. Pharmacol. 509 2004 211 217
4. E. Guillot, A. Coste, and I. Angel Involvement of capsaicin-sensitive nerves in the regulation of glucose tolerance in diabetic rats Life Sci. 59 1996 969 977
5. W.W. Lautt The HISS story overview: a novel hepatic neurohormonal regulation of peripheral insulin sensitivity in health and diabetes Can. J. Physiol. Pharm. 77 1999 553 562
6. Gy. Mózsik, A. Debreceni, I. Juricskay, O.M.E. Abdel-Salam, A. Ludány, and J. Szolcsányi A direct inhibitory effect of capsaicin on the gastric basal secretory responses in healthy subjects J. Physiol. (Paris) 93 1999 433 436
7. Gy. Mózsik, J. Szolcsányi, and I. Rácz Gastroprotection induced by capsaicin in healthy human subjects World J. Gastroenterol. 11 2005 5180 5184
8. I. Nagy, P. Sántha, G. Jancsó, and L. Urbán The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology Eur. J. Pharmacol. 500 2004 351 369
9. G. Oroszi, Z. Szilvássy, J. Németh, A. Tosaki, and J. Szolcsányi Interplay between nitric-oxide and CGRP by capsaicin in isolated guinea-pig heart Pharmacol. Res. 40 1999 125 128
10. P. Sadri, and W.W. Lautt Blockage of hepatic nitric-oxide synthase causes insulin resistance Am. J. Physiol. 277 1999 G101 G108
11. J. Szolcsányi Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: facts and scopes of and unorthodox neuroregulatory mechanism T. Kumazawa L. Kruger K. Misumura Progress in Brain Research vol. 113 1996 Elsevier Amsterdam 343 359
12. J. Szolcsányi, E. Pintér, and Zs. Helyes Sensocrine function of capsaicin-sensitive nociceptors mediated by somatostatin regulates against inflammation and hyperalgesia K. Bruje O. Hermann Hyperalgesia: Molecular Mechanisms and clinical Implications, Progress in Pain Research and Management vol. 30 2004 113 127
13. I. Tolan, D. Ragoobirsingh, and E.Y. Morrison The effect of capsaicin on blood glucose, plasma insulin levels and insulin binding in dog models Phytother. Res. 15 2001 391 394
14. M. Udupihille The effect of capsaicin on the small intestinal absorption of glucose and alanine in the rat Indian J. Physiol. Pharmacol. 37 1993 59 62
15. E.H.E.M. Van de Wall, D.X. Gram, J.H. Strubbe, A.J.W. Scheurink, and J.M. Koolhaas Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test Life Sci. 77 2005 1283 1292