KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults

Tuberculosis

Volumn 97, Issue , 2016, Pages 163-171

  Boer, Mardi C ^a   Van Meijgaarden, Krista E ^a   Goletti, Delia ^b   Vanini, Valentina ^b   Prins, Corine ^a   Ottenhoff, Tom H M ^a   Joosten, Simone A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

BCG vaccination; CTLA 4; Human T cells; Immune checkpoint blockade; Immunity; Inhibitory receptors; KLRG1; PD 1; T cell exhaustion; T cells; Terminal differentiation; Tuberculosis

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; KLRG1 PROTEIN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR; UNCLASSIFIED DRUG; BCG VACCINE; CTLA4 PROTEIN, HUMAN; KLRG1 PROTEIN, HUMAN; LECTIN; PDCD1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TUBERCULOSTATIC AGENT;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BCG VACCINATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TUBERCULOSIS; CASE CONTROL STUDY; CELL CULTURE; CELL DIFFERENTIATION; COMPARATIVE STUDY; DRUG EFFECTS; IMMUNOLOGY; LATENT TUBERCULOSIS; LYMPHOCYTE ACTIVATION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PATHOGENICITY; REMISSION; TIME FACTOR; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY; UPREGULATION; VACCINATION; YOUNG ADULT;

ADULT; ANTITUBERCULAR AGENTS; BCG VACCINE; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CTLA-4 ANTIGEN; FEMALE; HUMANS; LATENT TUBERCULOSIS; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PROGRAMMED CELL DEATH 1 RECEPTOR; REMISSION INDUCTION; T-LYMPHOCYTES; TIME FACTORS; TRANS-ACTIVATORS; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY; UP-REGULATION; VACCINATION; YOUNG ADULT;

EID: 84960463266     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2015.11.008     Document Type: Article

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