Increased frequency of CD4+CD25high Treg cells inhibit BCG-specific induction of IFN-γ by CD4+ T cells from TB patients

Tuberculosis

Volumn 87, Issue 6, 2007, Pages 526-534

  Li, Li ^a   Lao, Sui hua ^b   Wu, Chang you ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU CHEST HOSPITAL   (China)

Author keywords

GITR HLA DR; Treg; Tuberculosis

Indexed keywords

BCG VACCINE; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERFERON PRODUCTION; MALE; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TUBERCULOSIS;

ADOLESCENT; ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BCG VACCINE; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES, REGULATORY; TUBERCULOSIS;

EID: 35348977751     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2007.07.004     Document Type: Article

References (39)

1. Kaufmann S.H., and McMichael A.J. Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis. Nat Med 11 (2005) 33-44
2. Kaufmann S.H. Tuberculosis: back on the immunologists' agenda. Immunity 24 (2006) 351-357
3. Suvas S., and Rouse B.T. Treg control of antimicrobial T cell responses. Curr Opin Immunol 18 (2006) 344-348
4. Vahlenkamp T.W., Tompkins M.B., and Tompkins W.A. The role of CD4+CD25+ regulatory T cells in viral infections. Vet Immunol Immunopathol 108 (2005) 219-225
5. Thompson C., and Powrie F. Regulatory T cells. Curr Opin Pharmacol 4 (2004) 408-414
6. Belkaid Y., and Rouse B.T. Natural regulatory T cells in infectious disease. Nat Immunol 6 (2005) 353-360
7. Hirsch C.S., Toossi Z., Othieno C., Johnson J.L., Schwander S.K., Robertson S., et al. Depressed T cell interferongamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J Infect Dis 180 (1999) 2069-2073
8. Toossi Z., Kleinhenz M.E., and Ellner J.J. Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. J Exp Med 163 (1986) 1162-1172
9. Boussiotis V.A., Tsai E.Y., Yunis E.J., Thim S., Delgado J.C., Dascher C.C., et al. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest 105 (2000) 1317-1325
10. Othieno C., Hirsch C.S., Hamilton B.D., Wilkinson K., Ellner J.J., and Toossi Z. Interaction of Mycobacterium tuberculosis-induced transforming growth factor beta1 and interleukin-10. Infect Immun 67 (1999) 5730-5735
11. Roberts T., Beyers N., Aguirre A., and Walzl G. Immunosuppression during active tuberculosis is characterized by decreased interferon-gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor-beta, and interleukin-4 mRNA levels. J Infect Dis 195 (2007) 870-878
12. Baecher-Allan C., Brown J.A., Freeman G.J., and Hafler D.A. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 167 (2001) 1245-1253
13. Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4 (2003) 330-336
14. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
15. McHugh R.S., Whitters M.J., Piccirillo C.A., Young D.A., Shevach E.M., Collins M., et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16 (2002) 311-323
16. Read S., Greenwald R., Izcue A., Robinson N., Mandelbrot D., Francisco L., et al. Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 177 (2006) 4376-4383
17. Kim J.M., and Rudensky A. The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol Rev 212 (2006) 86-98
18. Ribeiro-Rodrigues R., Resende Co T., Rojas R., Toossi Z., Dietze R., Boom W.H., et al. A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis. Clin Exp Immunol 144 (2006) 25-34
19. Guyot-Revol V., Innes J.A., Hackforth S., Hinks T., and Lalvani A. Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am J Respir Crit Care Med 173 (2006) 803-810
20. Chen X., Zhou B., Li M., Deng Q., Wu X., Le X., et al. CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clin Immunol 123 (2007) 50-59
21. Hougardy J.M., Place S., Hildebrand M., Drowart A., Debrie A.S., Locht C., et al. Regulatory T Cells Depress Immune Responses to Protective Antigens in Active Tuberculosis. Am J Respir Crit Care Med 176 (2007) 409-416
22. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., and Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3 (2002) 135-142
23. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., and Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420 (2002) 502-507
24. Maloy K.J., and Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2 (2001) 816-822
25. Boettler T., Spangenberg H.C., Neumann-Haefelin C., Panther E., Urbani S., Ferrari C., et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 79 (2005) 7860-7867
26. Kinter A.L., Hennessey M., Bell A., Kern S., Lin Y., Daucher M., et al. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 200 (2004) 331-343
27. Aandahl E.M., Michaelsson J., Moretto W.J., Hecht F.M., and Nixon D.F. Human CD4+CD25+ regulatory T cells control T cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol 78 (2004) 2454-2459
28. Mendez S., Reckling S.K., Piccirillo C.A., Sacks D., and Belkaid Y. Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med 200 (2004) 201-210
29. McKinley L., Logar A.J., McAllister F., Zheng M., Steele C., and Kolls J.K. Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of pneumocystis pneumonia. J Immunol 177 (2006) 6215-6226
30. Rouse B.T., Sarangi P.P., and Suvas S. Regulatory T cells in virus infections. Immunol Rev 212 (2006) 272-286
31. Ikeda M., Takeshima F., Ohba K., Ohnita K., Isomoto H., Yamakawa M., et al. Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4(+) CD25(+) T cells of patients with inflammatory bowel disease. Dig Dis Sci 51 (2006) 178-184
32. Baecher-Allan C., Wolf E., and Hafler D.A. MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol 176 (2006) 4622-4631
33. Quinn K.M., McHugh R.S., Rich F.J., Goldsack L.M., de Lisle G.W., Buddle B.M., et al. Inactivation of CD4+CD25+ regulatory T cells during early mycobacterial infection increases cytokine production but does not affect pathogen load. Immunol Cell Biol 84 (2006) 467-474
34. Shevach E.M., Mchugh R.S., Piccirillo C.A., and Thornton A.M. Control of T-cell activation by CD4+CD25+ suppressor T cells. Immunol Rev 182 (2001) 58-67
35. Asseman C., Mauze S., Leach M.W., Coffman R.L., and Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190 (1999) 995-1004
36. Belghith M., Bluestone J.A., Barriot S., Megret J., Bach J.F., and Chatenoud L. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 9 (2003) 1202-1208
37. Maloy K.J., and Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2 (2001) 816-822
38. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., and Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420 (2002) 502-507
39. Cavassani K.A., Campanelli A.P., Moreira A.P., Vancim J.O., Vitali L.H., Mamede R.C., et al. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. J Immunol 177 (2006) 5811-5818