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Volumn 192, Issue 2, 2014, Pages 649-657

KLRG1 impairs CD4+ T cell responses via p16ink4a and p27kip1 pathways: Role in hepatitis B vaccine failure in individuals with hepatitis C virus infection

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN E; HEPATITIS A HEPATITIS B VACCINE; HEPATITIS B VACCINE; INTERLEUKIN 2; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY G MEMBER 1; PROTEIN KINASE B; RECOMBINANT HEPATITIS B VACCINE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84892758835     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302069     Document Type: Article
Times cited : (38)

References (49)
  • 1
    • 84878020722 scopus 로고    scopus 로고
    • Immune exhaustion and immune senescence: Two distinct pathways for HBV vaccine failure during HCV and/or HIV infection. [Review]
    • Yao, Z. Q., and J. P. Moorman. 2013. Immune exhaustion and immune senescence: two distinct pathways for HBV vaccine failure during HCV and/or HIV infection. [Review] Arch. Immunol. Ther. Exp. (Warsz.) 61: 193-201.
    • (2013) Arch. Immunol. Ther. Exp. (Warsz.) , vol.61 , pp. 193-201
    • Yao, Z.Q.1    Moorman, J.P.2
  • 2
    • 84875827526 scopus 로고    scopus 로고
    • Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: Role in hepatitis B vaccine failure during hepatitis C infection
    • Wang, J. M., C. J. Ma, G. Y. Li, X. Y. Wu, P. Thayer, P. Greer, A. M. Smith, K. P. High, J. P. Moorman, and Z. Q. Yao. 2013. Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: role in hepatitis B vaccine failure during hepatitis C infection. Vaccine 31: 2238-2245.
    • (2013) Vaccine , vol.31 , pp. 2238-2245
    • Wang, J.M.1    Ma, C.J.2    Li, G.Y.3    Wu, X.Y.4    Thayer, P.5    Greer, P.6    Smith, A.M.7    High, K.P.8    Moorman, J.P.9    Yao, Z.Q.10
  • 3
    • 84863630845 scopus 로고    scopus 로고
    • Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection
    • Moorman, J. P., J. M. Wang, Y. Zhang, X. J. Ji, C. J. Ma, X. Y. Wu, Z. S. Jia, K. S. Wang, and Z. Q. Yao. 2012. Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection. J. Immunol. 189: 755-766.
    • (2012) J. Immunol. , vol.189 , pp. 755-766
    • Moorman, J.P.1    Wang, J.M.2    Zhang, Y.3    Ji, X.J.4    Ma, C.J.5    Wu, X.Y.6    Jia, Z.S.7    Wang, K.S.8    Yao, Z.Q.9
  • 6
    • 79954608578 scopus 로고    scopus 로고
    • Impaired hepatitis B vaccine responses during chronic hepatitis C infection: Involvement of the PD-1 pathway in regulating CD4(+) T cell responses
    • Moorman, J. P., C. L. Zhang, L. Ni, C. J. Ma, Y. Zhang, X. Y. Wu, P. Thayer, T. M. Islam, T. Borthwick, and Z. Q. Yao. 2011. Impaired hepatitis B vaccine responses during chronic hepatitis C infection: involvement of the PD-1 pathway in regulating CD4(+) T cell responses. Vaccine 29: 3169-3176.
    • (2011) Vaccine , vol.29 , pp. 3169-3176
    • Moorman, J.P.1    Zhang, C.L.2    Ni, L.3    Ma, C.J.4    Zhang, Y.5    Wu, X.Y.6    Thayer, P.7    Islam, T.M.8    Borthwick, T.9    Yao, Z.Q.10
  • 7
    • 68249141859 scopus 로고    scopus 로고
    • Response to hepatitis A and B vaccine alone or in combination in patients with chronic hepatitis C virus and advanced fibrosis
    • Kramer, E. S., C. Hofmann, P. G. Smith, M. L. Shiffman, and R. K. Sterling. 2009. Response to hepatitis A and B vaccine alone or in combination in patients with chronic hepatitis C virus and advanced fibrosis. Dig. Dis. Sci. 54: 2016-2025.
    • (2009) Dig. Dis. Sci. , vol.54 , pp. 2016-2025
    • Kramer, E.S.1    Hofmann, C.2    Smith, P.G.3    Shiffman, M.L.4    Sterling, R.K.5
  • 8
    • 0036901212 scopus 로고    scopus 로고
    • The effect of age on immunologic response to recombinant hepatitis B vaccine: A meta-analysis
    • DOI 10.1086/344271
    • Fisman, D. N., D. Agrawal, and K. Leder. 2002. The effect of age on immunologic response to recombinant hepatitis B vaccine: a meta-analysis. Clin. Infect. Dis. 35: 1368-1375. (Pubitemid 35448965)
    • (2002) Clinical Infectious Diseases , vol.35 , Issue.11 , pp. 1368-1375
    • Fisman, D.N.1    Agrawal, D.2    Leder, K.3
  • 9
    • 20144375709 scopus 로고    scopus 로고
    • Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness
    • DOI 10.1002/hep.20716
    • Godkin, A., M. Davenport, and A. V. Hill. 2005. Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness. Hepatology 41: 1383-1390. (Pubitemid 40774886)
    • (2005) Hepatology , vol.41 , Issue.6 , pp. 1383-1390
    • Godkin, A.1    Davenport, M.2    Hill, A.V.S.3
  • 10
    • 0035515368 scopus 로고    scopus 로고
    • Family study of non-responsiveness to hepatitis B vaccine confirms the importance of HLA class III C4A locus
    • DOI 10.1038/sj.gene.6363792
    • De Silvestri, A., A. Pasi, M. Martinetti, C. Belloni, C. Tinelli, G. Rondini, L. Salvaneschi, and M. Cuccia. 2001. Family study of non-responsiveness to hepatitis B vaccine confirms the importance of HLA class III C4A locus. Genes Immun. 2: 367-372. (Pubitemid 33674251)
    • (2001) Genes and Immunity , vol.2 , Issue.7 , pp. 367-372
    • De Silvestri, A.1    Pasi, A.2    Martinetti, M.3    Belloni, C.4    Tinelli, C.5    Rondini, G.6    Salvaneschi, L.7    Cuccia, M.8
  • 12
    • 23144439247 scopus 로고    scopus 로고
    • Profiles of NK, NKT cell activation and cytokine production following vaccination against hepatitis B
    • DOI 10.1111/j.1600-0463.2005.apm-191.x
    • Albarran, B., L. Goncalves, S. Salmen, L. Borges, H. Fields, A. Soyano, H. Montes, and L. Berrueta. 2005. Profiles of NK, NKT cell activation and cytokine production following vaccination against hepatitis B. APMIS 113: 526-535. (Pubitemid 41081477)
    • (2005) APMIS , vol.113 , Issue.7-8 , pp. 526-535
    • Albarran, B.1    Goncalves, L.2    Salmen, S.3    Borges, L.4    Fields, H.5    Soyano, A.6    Montes, H.7    Berrueta, L.8
  • 13
    • 3242687250 scopus 로고    scopus 로고
    • The nonresponse to hepatitis B vaccination is associated with impaired lymphocyte activation
    • DOI 10.1016/j.virol.2004.04.042, PII S0042682204003332
    • Goncalves, L., B. Albarran, S. Salmen, L. Borges, H. Fields, H. Montes, A. Soyano, Y. Diaz, and L. Berrueta. 2004. The nonresponse to hepatitis B vaccination is associated with impaired lymphocyte activation. Virology 326: 20-28. (Pubitemid 38943002)
    • (2004) Virology , vol.326 , Issue.1 , pp. 20-28
    • Goncalves, L.1    Albarran, B.2    Salmen, S.3    Borges, L.4    Fields, H.5    Montes, H.6    Soyano, A.7    Diaz, Y.8    Berrueta, L.9
  • 14
    • 29544432932 scopus 로고    scopus 로고
    • Hepatitis B surface antigen-specific T and B cell memory in individuals who had lost protective antibodies after hepatitis B vaccination
    • DOI 10.1016/j.vaccine.2005.08.058, PII S0264410X05008741
    • Bauer, T., and W. Jilg. 2006. Hepatitis B surface antigen-specific T and B cell memory in individuals who had lost protective antibodies after hepatitis B vaccination. Vaccine 24: 572-577. (Pubitemid 43017822)
    • (2006) Vaccine , vol.24 , Issue.5 , pp. 572-577
    • Bauer, T.1    Jilg, W.2
  • 15
    • 33947397282 scopus 로고    scopus 로고
    • Vaccination against hepatitis B in liver transplant recipients: Pilot analysis of cellular immune response shows evidence of HBsAg-specific regulatory T cells
    • DOI 10.1002/lt.21061
    • Bauer, T., M. Günther, U. Bienzle, R. Neuhaus, and W. Jilg. 2007. Vaccination against hepatitis B in liver transplant recipients: pilot analysis of cellular immune response shows evidence of HBsAg-specific regulatory T cells. Liver Transpl. 13: 434-442. (Pubitemid 46444473)
    • (2007) Liver Transplantation , vol.13 , Issue.3 , pp. 434-442
    • Bauer, T.1    Gunther, M.2    Bienzle, U.3    Neuhaus, R.4    Jilg, W.5
  • 17
    • 34447128944 scopus 로고    scopus 로고
    • Decreased antigen-specific T-cell proliferation by moDC among hepatitis B vaccine non-responders on haemodialysis
    • DOI 10.1007/s10238-007-0127-x
    • Verkade, M. A., C. J. van Druningen, C. T. Op de Hoek, W. Weimar, and M. G. Betjes. 2007. Decreased antigen-specific T-cell proliferation by moDC among hepatitis B vaccine non-responders on haemodialysis. Clin. Exp. Med. 7: 65-71. (Pubitemid 47036745)
    • (2007) Clinical and Experimental Medicine , vol.7 , Issue.2 , pp. 65-71
    • Verkade, M.A.1    Van Druningen, C.J.2    Op De Hoek, C.T.3    Weimar, W.4    Betjes, M.G.H.5
  • 18
    • 16244387925 scopus 로고    scopus 로고
    • Non-responsiveness to hepatitis B surface antigen vaccines is not caused by defective antigen presentation or a lack of B7 co-stimulation
    • DOI 10.1111/j.1365-2249.2004.02749.x
    • Desombere, I., T. Cao, Y. Gijbels, and G. Leroux-Roels. 2005. Nonresponsiveness to hepatitis B surface antigen vaccines is not caused by defective antigen presentation or a lack of B7 co-stimulation. Clin. Exp. Immunol. 140: 126-137. (Pubitemid 40461082)
    • (2005) Clinical and Experimental Immunology , vol.140 , Issue.1 , pp. 126-137
    • Desombere, I.1    Cao, T.2    Gijbels, Y.3    Leroux-Roels, G.4
  • 19
    • 0028831140 scopus 로고
    • Nonresponders to hepatitis B vaccine can present envelope particles to T lymphocytes
    • Desombere, I., P. Hauser, R. Rossau, J. Paradijs, and G. Leroux-Roels. 1995. Nonresponders to hepatitis B vaccine can present envelope particles to T lymphocytes. J. Immunol. 154: 520-529.
    • (1995) J. Immunol. , vol.154 , pp. 520-529
    • Desombere, I.1    Hauser, P.2    Rossau, R.3    Paradijs, J.4    Leroux-Roels, G.5
  • 20
    • 0036841343 scopus 로고    scopus 로고
    • The immunogenicity and reactogenicity profile of a candidate hepatitis B vaccine in an adult vaccine non-responder population
    • DOI 10.1016/S0264-410X(02)00397-3, PII S0264410X02003973
    • Jacques, P., G. Moens, I. Desombere, J. Dewijngaert, G. Leroux-Roels, M. Wettendorff, and S. Thoelen. 2002. The immunogenicity and reactogenicity profile of a candidate hepatitis B vaccine in an adult vaccine non-responder population. Vaccine 20: 3644-3649. (Pubitemid 35223393)
    • (2002) Vaccine , vol.20 , Issue.31-32 , pp. 3644-3649
    • Jacques, P.1    Moens, G.2    Desombere, I.3    Dewijngaert, J.4    Leroux-Roels, G.5    Wettendorff, M.6    Thoelen, S.7
  • 21
    • 0037424116 scopus 로고    scopus 로고
    • Revaccination of healthy nonresponders with hepatitis B vaccine and prediction of seroprotection response
    • DOI 10.1016/S0264-410X(02)00626-6, PII S0264410X02006266
    • Kim, M. J., A. N. Nafziger, C. D. Harro, H. L. Keyserling, K. M. Ramsey, G. L. Drusano, and J. S. Bertino, Jr. 2003. Revaccination of healthy nonresponders with hepatitis B vaccine and prediction of seroprotection response. Vaccine 21: 1174-1179. (Pubitemid 36139946)
    • (2003) Vaccine , vol.21 , Issue.11-12 , pp. 1174-1179
    • Kim, M.-J.1    Nafziger, A.N.2    Harro, C.D.3    Keyserling, H.L.4    Ramsey, K.M.5    Drusano, G.L.6    Bertino Jr., J.S.7
  • 22
    • 0030452080 scopus 로고    scopus 로고
    • Low-dose intramuscular revaccination against hepatitis B
    • DOI 10.1016/S0264-410X(96)00134-X, PII S0264410X9600134X
    • Ramon, J. M., R. Bou, and J. Oromi. 1996. Low-dose intramuscular revaccination against hepatitis B. Vaccine 14: 1647-1650. (Pubitemid 27041917)
    • (1996) Vaccine , vol.14 , Issue.17-18 , pp. 1647-1650
    • Ramon, J.M.1    Bou, R.2    Oromi, J.3
  • 23
    • 0033967584 scopus 로고    scopus 로고
    • Cellular and humoral immune responses induced by intradermal or intramuscular vaccination with the major hepatitis B surface antigen
    • Rahman, F., A. Dahmen, S. Herzog-Hauff, W. O. Böcher, P. R. Galle, and H. F. Löhr. 2000. Cellular and humoral immune responses induced by intradermal or intramuscular vaccination with the major hepatitis B surface antigen. Hepatology 31: 521-527. (Pubitemid 30078622)
    • (2000) Hepatology , vol.31 , Issue.2 , pp. 521-527
    • Rahman, F.1    Dahmen, A.2    Herzog-Hauff, S.3    Bocher, W.O.4    Galle, P.R.5    Lohr, H.E.6
  • 24
    • 55249120890 scopus 로고    scopus 로고
    • Improved cell mediated immune responses after successful re-vaccination of non-responders to the hepatitis B virus surface antigen (HBsAg) vaccine using the combined hepatitis A and B vaccine
    • Nyström, J., K. Cardell, T. B. Björnsdottir, A. Fryden, C. Hultgren, and M. Sällberg. 2008. Improved cell mediated immune responses after successful re-vaccination of non-responders to the hepatitis B virus surface antigen (HBsAg) vaccine using the combined hepatitis A and B vaccine. Vaccine 26: 5967-5972.
    • (2008) Vaccine , vol.26 , pp. 5967-5972
    • Nyström, J.1    Cardell, K.2    Björnsdottir, T.B.3    Fryden, A.4    Hultgren, C.5    Sällberg, M.6
  • 25
    • 0037111658 scopus 로고    scopus 로고
    • Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)
    • DOI 10.1182/blood-2002-02-0657
    • Voehringer, D., M. Koschella, and H. Pircher. 2002. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 100: 3698-3702. (Pubitemid 35303941)
    • (2002) Blood , vol.100 , Issue.10 , pp. 3698-3702
    • Voehringer, D.1    Koschella, M.2    Pircher, H.3
  • 26
    • 18644378123 scopus 로고    scopus 로고
    • + T lymphocytes during active, latent, and resolved infection and its relation with CD57
    • Ibegbu, C. C., Y. X. Xu, W. Harris, D. Maggio, J. D. Miller, and A. P. Kourtis. 2005. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. J. Immunol. 174: 6088-6094. (Pubitemid 40663797)
    • (2005) Journal of Immunology , vol.174 , Issue.10 , pp. 6088-6094
    • Ibegbu, C.C.1    Xu, Y.-X.2    Harris, W.3    Maggio, D.4    Miller, J.D.5    Kourtis, A.P.6
  • 27
    • 0037944109 scopus 로고    scopus 로고
    • Differential regulation of killer cell lectin-like receptor G1 expression on T cells
    • Robbins, S. H., S. C. Terrizzi, B. C. Sydora, T. Mikayama, and L. Brossay. 2003. Differential regulation of killer cell lectin-like receptor G1 expression on T cells. J. Immunol. 170: 5876-5885. (Pubitemid 36682566)
    • (2003) Journal of Immunology , vol.170 , Issue.12 , pp. 5876-5885
    • Robbins, S.H.1    Terrizzi, S.C.2    Sydora, B.C.3    Mikayama, T.4    Brossay, L.5
  • 31
    • 44449145582 scopus 로고    scopus 로고
    • IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii infection
    • Wilson, D. C., S. Matthews, and G. S. Yap. 2008. IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii infection. J. Immunol. 180: 5935-5945.
    • (2008) J. Immunol. , vol.180 , pp. 5935-5945
    • Wilson, D.C.1    Matthews, S.2    Yap, G.S.3
  • 34
    • 77954674575 scopus 로고    scopus 로고
    • Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
    • Bengsch, B., B. Seigel, M. Ruhl, J. Timm, M. Kuntz, H. E. Blum, H. Pircher, and R. Thimme. 2010. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog. 6: e1000947.
    • (2010) PLoS Pathog. , vol.6
    • Bengsch, B.1    Seigel, B.2    Ruhl, M.3    Timm, J.4    Kuntz, M.5    Blum, H.E.6    Pircher, H.7    Thimme, R.8
  • 36
    • 0031943168 scopus 로고    scopus 로고
    • Different hepatitis C virus (HCV) RNA load profiles following seroconversion among injecting drug users without correlation with HCV genotype and serum alanine aminotransferase levels
    • Beld, M., M. Penning, M. McMorrow, J. Gorgels, A. V. D. Hoek, and J. Goudsmit. 1998. Different hepatitis C virus (HCV) RNA load profiles following seroconversion among injecting drug users without correlation with HCV genotype and serum alanine aminotransferase levels. J. Clin. Microbiol. 36: 872-877. (Pubitemid 28146261)
    • (1998) Journal of Clinical Microbiology , vol.36 , Issue.4 , pp. 872-877
    • Beld, M.1    Penning, M.2    Mcmorrow, M.3    Gorgels, J.4    Van Den Hoek, A.5    Goudsmit, J.6
  • 37
    • 84863089861 scopus 로고    scopus 로고
    • Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation
    • Patsoukis, N., J. Brown, V. Petkova, F. Liu, L. Li, and V. A. Boussiotis. 2012. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci. Signal. 5: ra46.
    • (2012) Sci. Signal. , vol.5
    • Patsoukis, N.1    Brown, J.2    Petkova, V.3    Liu, F.4    Li, L.5    Boussiotis, V.A.6
  • 38
    • 84880417938 scopus 로고    scopus 로고
    • Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexes
    • Martin, N., S. Raguz, G. Dharmalingam, and J. Gil. 2013. Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexes. Cell Cycle 12: 2194-2199.
    • (2013) Cell Cycle , vol.12 , pp. 2194-2199
    • Martin, N.1    Raguz, S.2    Dharmalingam, G.3    Gil, J.4
  • 39
    • 0036885116 scopus 로고    scopus 로고
    • Oncolytic viruses
    • DOI 10.1038/nrc948
    • Chiocca, E. A. 2002. Oncolytic viruses. Nat. Rev. Cancer 2: 938-950. (Pubitemid 37328895)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.12 , pp. 938-950
    • Chiocca, E.A.1
  • 40
    • 2642546429 scopus 로고    scopus 로고
    • + T cells leads to impaired activation of Lck and Akt
    • DOI 10.1128/JVI.78.12.6409-6419.2004
    • Yao, Z. Q., A. Eisen-Vandervelde, S. N. Waggoner, E. M. Cale, and Y. S. Hahn. 2004. Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J. Virol. 78: 6409-6419. (Pubitemid 38715939)
    • (2004) Journal of Virology , vol.78 , Issue.12 , pp. 6409-6419
    • Yao, Z.Q.1    Eisen-Vandervelde, A.2    Waggoner, S.N.3    Cale, E.M.4    Hahn, Y.S.5
  • 41
    • 0141568819 scopus 로고    scopus 로고
    • Kip1
    • DOI 10.1016/S0042-6822(03)00419-7
    • Yao, Z. Q., A. Eisen-Vandervelde, S. Ray, and Y. S. Hahn. 2003. HCV core/gC1qR interaction arrests T cell cycle progression through stabilization of the cell cycle inhibitor p27Kip1. Virology 314: 271-282. (Pubitemid 37153316)
    • (2003) Virology , vol.314 , Issue.1 , pp. 271-282
    • Yao, Z.Q.1    Eisen-Vandervelde, A.2    Ray, S.3    Hahn, Y.S.4
  • 42
    • 84879105286 scopus 로고    scopus 로고
    • Control of chronic Mycobacterium tuberculosis infection by CD4 KLRG12 IL-2-secreting central memory cells
    • Lindenstrøm, T., N. P. Knudsen, E. M. Agger, and P. Andersen. 2013. Control of chronic Mycobacterium tuberculosis infection by CD4 KLRG12 IL-2-secreting central memory cells. J. Immunol. 190: 6311-6319.
    • (2013) J. Immunol. , vol.190 , pp. 6311-6319
    • Lindenstrøm, T.1    Knudsen, N.P.2    Agger, E.M.3    Andersen, P.4
  • 44
    • 0028092072 scopus 로고
    • Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults
    • Hayward, A. R., K. Buda, and M. J. Levin. 1994. Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults. Viral Immunol. 7: 31-36. (Pubitemid 24330461)
    • (1994) Viral Immunology , vol.7 , Issue.1 , pp. 31-36
    • Hayward, A.R.1    Buda, K.2    Levin, M.J.3
  • 45
    • 0036174472 scopus 로고    scopus 로고
    • The humoral response to live and inactivated influenza vaccines administered alone and in combination to young adults and elderly
    • DOI 10.1016/S1386-6532(01)00246-3, PII S1386653201002463
    • Stepanova, L., A. Naykhin, C. Kolmskog, G. Jonson, I. Barantceva, M. Bichurina, O. Kubar, and A. Linde. 2002. The humoral response to live and inactivated influenza vaccines administered alone and in combination to young adults and elderly. J. Clin. Virol. 24: 193-201. (Pubitemid 34154866)
    • (2002) Journal of Clinical Virology , vol.24 , Issue.3 , pp. 193-201
    • Stepanova, L.1    Naykhin, A.2    Kolmskog, C.3    Jonson, G.4    Barantceva, I.5    Bichurina, M.6    Kubar, O.7    Linde, A.8
  • 46
    • 84884144572 scopus 로고    scopus 로고
    • Vaccine strategies to enhance immune responses in the aged
    • Lefebvre, J. S., and L. Haynes. 2013. Vaccine strategies to enhance immune responses in the aged. Curr. Opin. Immunol. 25: 523-528.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 523-528
    • Lefebvre, J.S.1    Haynes, L.2
  • 48
    • 0042160250 scopus 로고    scopus 로고
    • Response of human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy to vaccination with 23-valent pneumococcal polysaccharide vaccine
    • DOI 10.1086/375841
    • Rodriguez-Barradas, M. C., I. Alexandraki, T. Nazir, M. Foltzer, D. M. Musher, S. Brown, and J. Thornby. 2003. Response of human immunodeficiency virusinfected patients receiving highly active antiretroviral therapy to vaccination with 23-valent pneumococcal polysaccharide vaccine. Clin. Infect. Dis. 37: 438-447. (Pubitemid 36976504)
    • (2003) Clinical Infectious Diseases , vol.37 , Issue.3 , pp. 438-447
    • Rodriguez-Barradas, M.C.1    Alexandraki, I.2    Nazir, T.3    Foltzer, M.4    Musher, D.M.5    Brown, S.6    Thornby, J.7


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