Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a)

Metabolism: Clinical and Experimental

Volumn 65, Issue 4, 2016, Pages 381-390

  Diffenderfer, Margaret R ^a   Lamon Fava, Stefania ^a   Marcovina, Santica M ^b   Barrett, P Hugh R ^c   Lel, Julian ^a   Dolnikowski, Gregory G ^a   Berglund, Lars ^d   Schaefer, Ernst J ^a  

^a TUFTS UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fed state; Hypertriglyceridemia; Kinetics; Lipoprotein(a)

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN B100; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERMEDIATE DENSITY LIPOPROTEIN; LEUCINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; MONOCLONAL ANTIBODY; NICOTINIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; APOB PROTEIN, HUMAN; LIPID; LIPOPROTEIN A;

ADULT; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; DYSLIPIDEMIA; FOOD INTAKE; HUMAN; IMMUNOPRECIPITATION; LIPOLYSIS; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; LIPOPROTEIN SYNTHESIS; MALE; MIDDLE AGED; MOLECULAR WEIGHT; PLASMA; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TRIACYLGLYCEROL BLOOD LEVEL; BIOSYNTHESIS; BLOOD; HYPERTRIGLYCERIDEMIA; KINETICS; METABOLISM;

APOLIPOPROTEIN B-100; APOLIPOPROTEINS A; DYSLIPIDEMIAS; HUMANS; HYPERTRIGLYCERIDEMIA; KINETICS; LEUCINE; LIPIDS; LIPOPROTEIN(A); MALE; MIDDLE AGED;

EID: 84960452830     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.10.031     Document Type: Article

References (55)

1. K. Berg A new serum type system in man-the Lp system Acta Pathol Microbiol Scand 59 1963 369 382
2. J.W. Gaubatz, C. Heideman, A.M. Gotto Jr., J.D. Morrisett, and G.H. Dahlen Human plasma lipoprotein [a]. Structural properties J Biol Chem 258 1983 4582 4589
3. M.L. Koschinsky, G.P. Côté, B. Gabel, and Y.Y. van der Hoek Identification of the cysteine residue in apolipoprotein(a) that mediates extracellular coupling with apolipoprotein B-100 J Biol Chem 268 1993 19819 19825
4. J.J. Albers, H. Kennedy, and S.M. Marcovina Evidence that Lp[a] contains one molecule of apo[a] and one molecule of apoB: Evaluation of amino acid analysis data J Lipid Res 37 1996 192 196
5. J.W. McLean, J.E. Tomlinson, W.-J. Kuang, D.L. Eaton, E.Y. Chen, G.M. Fless, and et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen Nature 300 1987 132 137
6. C. Lackner, J.C. Cohen, and H.H. Hobbs Molecular definition of the extreme size polymorphism in apolipoprotein(a) Hum Mol Genet 2 1993 933 940
7. H.H. Hobbs, and A.L. White Lipoprotein(a): Intrigues and insights Curr Opin Lipidol 10 1999 225 236
8. E.J. Schaefer, S. Lamon-Fava, J.L. Jenner, J.R. McNamara, J.M. Ordovas, C.E. Davis, and et al. Lipoprotein(a) levels and risk of coronary heart disease in men. The Lipid Research Clinics Coronary Primary Prevention Trial JAMA 271 1994 999 1003
9. S. Lamon-Fava, S.M. Marcovina, J.J. Albers, H. Kennedy, C. DeLuca, C.C. White, and et al. Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study J Lipid Res 52 2011 1181 1187
10. S. Lamon-Fava, M.R. Diffenderfer, and S.M. Marcovina Lipoprotein(a) metabolism Curr Opin Lipidol 25 2014 189 193
11. C. Bergmark, A. Dewan, A. Orsoni, E. Merki, E.R. Miller, M.-J. Shin, and et al. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma J Lipid Res 49 2008 2230 2239
12. S.N. Sotiriou, V.V. Orlova, N. Al-Fakhri, E. Ihanus, M. Economopoulou, B. Isermann, and et al. Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin FASEB J 20 2006 559 561
13. S.M. Marcovina, and M.L. Koschinsky Evaluation of lipoprotein(a) as a prothrombotic factor: Progress from bench to bedside Curr Opin Lipidol 14 2003 361 366
14. J.D. Spence, and M. Koschinsky Mechanisms of lipoprotein(a) pathogenicity: Prothrombotic, proatherosclerotic, or both? Arterioscler Thromb Vasc Biol 32 2012 1550 1551
15. J.R. Guyton, G.H. Dahlen, W. Patsch, J.A. Kautz, and A.M. Gotto Jr. Relationship of plasma lipoprotein Lp(a) levels to race and to apolipoprotein B Arterioscler Thromb Vasc Biol 5 1985 265 272
16. E. Boerwinkle, C.C. Leffert, J. Lin, C. Lackner, G. Chiesa, and H.H. Hobbs Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations J Clin Invest 90 1992 52 60
17. C. Sandholzer, D.M. Hallman, N. Saha, G. Sigurdsson, C. Lackner, A. Császár, and et al. Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups Hum Genet 86 1991 607 614
18. R. Clarke, J.F. Peden, J.C. Hopewell, T. Kyriakou, A. Goel, S.C. Heath, and et al. Genetic variants associated with Lp(a) lipoprotein level and coronary disease N Engl J Med 36 2009 2518 2528
19. J. Hoover-Plow, and M. Huang Lipoprotein(a) metabolism: Potential sites for therapeutic targets Metabolism 62 2013 479 491
20. D.J. Rader, W. Cain, K. Ikewaki, G. Talley, L.A. Zech, D. Usher, and et al. The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate J Clin Invest 93 1994 2758 2763
21. M.B. Boffa, and M.L. Koschinsky Update on lipoprotein(a) as a cardiovascular risk factor and mediator Curr Atheroscler Rep 15 2013 360
22. M.E. Frischmann, K. Ikewaki, E. Trenkwalder, C. Lamina, B. Dieplinger, M. Soufi, and et al. In vivo stable-isotope kinetic study suggests intracellular assembly of lipoprotein(a) Atherosclerosis 225 2012 322 327
23. M.E. Frischmann, F. Kronenberg, E. Trenkwalder, J.R. Schaefer, H. Schweer, B. Dieplinger, and et al. In vivo turnover study demonstrates diminished clearance of lipoprotein(a) in hemodialysis patients Kidney Int 71 2007 1036 1043
24. W.J. Cain, J.S. Millar, A.S. Himebauch, U.J.F. Tietge, C. Maugeais, D. Usher, and et al. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a] J Lipid Res 46 2005 2681 2691
25. R. Romagnuolo, C.A. Scipione, M.B. Boffa, S.M. Marcovina, N.G. Seidah, and M.L. Koschinsky Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor J Biol Chem 290 2015 11649 11662
26. L.J. Seman, and W.C. Breckenridge Isolation and partial characterization of apolipoprotein(a) from human lipoprotein(a) Biochem Cell Biol 64 1986 999 1009
27. O. Klezovitch, and A.M. Scanu Heterogeneity of lipoprotein(a): Growing complexities Curr Opin Lipidol 6 1995 223 228
28. J.S. Cohn, C.W.K. Lam, D.R. Sullivan, and W.J. Hensley Plasma lipoprotein distribution of apolipoprotein(a) in the fed and fasted states Atherosclerosis 90 1991 59 66
29. T.P. Bersot, T.L. Innerarity, R.E. Pitas, S.C. Rall Jr., K.H. Weisgraber, and R.W. Mahley Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein[a] and that cause lipid accumulation in macrophages J Clin Invest 77 1986 622 630
30. D. Pfaffinger, J. Schuelke, C. Kim, G.M. Fless, and A.M. Scanu Relationship between apo[a] isoforms and Lp[a] density in subjects with different apo[a] phenotype: A study before and after a fatty meal J Lipid Res 32 1991 679 683
31. T. Ishikawa, T. Yamashita, K. Mochizuki, K. Suzuki, N. Hashizume, and H. Nakamura Changes in the concentration and distribution of lipoprotein (a) in plasma after fat intake J Atheroscler Thromb 2 Suppl. 1 1995 S17 S21
32. J.D. Morrisett, J.W. Gaubatz, M.N. Nava, J.R. Guyton, A.S. Hoffman, A.R. Opekun, and et al. Metabolism of apo(a) and apoB-100 in human lipoprotein(a) A.L. Catapano, A.M. Gotto Jr. L.C. Smith, R. Paoletti, Drugs affecting lipid metabolism 1993 Kluwer Academic Publishers Dordrecht, Netherlands 161 167
33. W. Su, H. Campos, H. Judge, B.W. Walsh, and F.M. Sacks Metabolism of apo(a) and apoB100 of lipoprotein(a) in women: Effect of postmenopausal estrogen replacement J Clin Endocrinol Metab 83 1998 3267 3276
34. J.L. Jenner, L.J. Seman, J.S. Millar, S. Lamon-Fava, F.K. Welty, G.G. Dolnikowski, and et al. The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings Metabolism 54 2005 361 369
35. S. Lamon-Fava, M.R. Diffenderfer, P.H.R. Barrett, A. Buchsbaum, M. Nyaku, K.V. Horvath, and et al. Extended-release niacin alters the metabolism of plasma apolipoprotein (apo) A-I and apoB-containing lipoproteins Arterioscler Thromb Vasc Biol 28 2008 1672 1678
36. L.A. Carlson, A. Hamsten, and A. Asplund Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid J Intern Med 226 1989 271 276
37. J.S. Cohn, D.A. Wagner, S.D. Cohn, J.S. Millar, and E.J. Schaefer Measurement of very low density and low density lipoprotein apolipoprotein (apo) B-100 and high density lipoprotein apoA-I production in human subjects using deuterated leucine. Effect of fasting and feeding J Clin Invest 85 1990 804 811
38. NCEP Expert Panel Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) JAMA 285 2001 2486 2497
39. S.M. Marcovina, J.J. Albers, B. Gabel, M.L. Koschinsky, and V.P. Gaur Effect of the number of apolipoprotein(a) kringle 4 domains on immunochemical measurements of lipoprotein(a) Clin Chem 41 1995 246 255
40. S.M. Marcovina, H.H. Hobbs, and J.J. Albers Relation between number of apolipoprotein(a) kringle 4 repeats and mobility of isoforms in agarose gel: Basis for a standardized isoform nomenclature Clin Chem 42 1996 436 439
41. S. Lamon-Fava, M.R. Diffenderfer, P.H.R. Barrett, A. Buchsbaum, N.R. Matthan, A.H. Lichtenstein, and et al. Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism J Lipid Res 48 2007 1746 1753
42. V.N. Trieu, T.F. Zioncheck, R.M. Lawn, and W.J. McConathy Interaction of apolipoprotein(a) with apolipoprotein B-containing lipoproteins J Biol Chem 266 1991 5480 5485
43. C. Cobelli, G. Toffolo, D.M. Bier, and R. Nosadini Models to interpret kinetic data in stable isotope tracer studies Am J Physiol 253 1987 E551 E564
44. C. Edelstein, K. Nakajima, D. Pfaffinger, and A.M. Scanu Oxidative events cause degradation of apoB-100 but not of apo[a] and facilitate enzymatic cleavage of both proteins J Lipid Res 42 2001 1664 1670
45. T. Demant, K. Seeberg, A. Bedynek, and D. Seidel The metabolism of lipoprotein(a) and other apolipoprotein B-containing lipoproteins: A kinetic study in humans Atherosclerosis 157 2001 325 339
46. C. Marcoux, S. Lussier-Cacan, J. Davignon, and J.S. Cohn Association of Lp(a) rather than integrally-bound apo(a) with triglyceride-rich lipoproteins of human subjects Biochim Biophys Acta 1346 1997 261 274
47. J.W. Gaubatz, R.C. Hoogeveen, A.S. Hoffman, K.G. Ghazzaly, H.J. Pownall, J. Guevara Jr., and et al. Isolation, quantitation, and characterization of a stable complex formed by Lp[a] binding to triglyceride-rich lipoproteins J Lipid Res 42 2001 2058 2068
48. J.R. McNamara, H. Campos, J.L. Adolphson, J.M. Ordovas, P.W.F. Wilson, J.J. Albers, and et al. Screening for lipoprotein[a] elevations in plasma and assessment of size heterogeneity using gradient gel electrophoresis J Lipid Res 30 1989 747 755
49. F. Krempler, G.M. Kostner, K. Bolzano, and F. Sandhofer Turnover of lipoprotein (a) in man J Clin Invest 65 1980 1483 1490
50. F. Krempler, G.M. Kostner, A. Roscher, F. Haslauer, K. Bolzano, and F. Sandhofer Studies on the role of specific cell surface receptors in the removal of lipoprotein (a) in man J Clin Invest 71 1983 1431 1441
51. D.J. Rader, W. Cain, L.A. Zech, D. Usher, and H.B. Brewer Jr. Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production J Clin Invest 91 1993 443 447
52. D.J. Rader, W.A. Mann, W. Cain, H.-G. Kraft, D. Usher, L.A. Zech, and et al. The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans J Clin Invest 95 1995 1403 1408
53. H.G. Kraft, A. Lingenhel, F.J. Raal, M. Hohenegger, and G. Utermann Lipoprotein(a) in homozygous familial hypercholesterolemia Arterioscler Thromb Vasc Biol 20 2000 522 528
54. N.R. Desai, P. Kohli, R.P. Giugliano, M.L. O'Donoghue, R. Somaratne, J. Zhou, and et al. AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: An analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 Trial Circulation 128 2013 962 969
55. M. Croyal, K. Ouguerram, M. Passard, V. Ferchaud-Roucher, M. Chétiveaux, S. Billon-Crossouard, and et al. Effects of extended-release nicotinic acid on apolipoprotein (a) kinetics in hypertriglyceridemic patients Arterioscler Thromb Vasc Biol 35 2015 2042 2047