The metabolism of lipoprotein(a) and other apolipoprotein B-containing lipoproteins: A kinetic study in humans

Atherosclerosis

Volumn 157, Issue 2, 2001, Pages 325-339

  Demant, Thomas ^a,b   Seeberg, Katja ^a   Bedynek, Andrea ^a   Seidel, Dietrich ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b ACADEMIC TEACHING HOSPITAL DRESDEN FRIEDRICHSTADT   (Germany)

Author keywords

Apolipoprotein B; Apolipoprotein(a); Lipoprotein(a); Low density lipoprotein (LDL); Metabolic modeling; Stable isotopes

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN B; LEUCINE; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; TRACER; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CARDIOVASCULAR DISEASE; CATABOLISM; CIRCULATION; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; FEMALE; HUMAN; KINETICS; LIPOPROTEIN METABOLISM; LIVER; MALE; MASS SPECTROMETRY; MEASUREMENT; PRIORITY JOURNAL; RISK FACTOR; SECRETION;

ADULT; APOLIPOPROTEINS B; FEMALE; HUMANS; KINETICS; LIPOPROTEIN(A); LIPOPROTEINS; LIPOPROTEINS, IDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PROTEIN ISOFORMS;

EID: 0034904706     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00732-2     Document Type: Article

References (45)

1. Isolation, characterization, and uptake in human fibroblasts of an apo(a)-free lipoprotein obtained on reduction of lipoprotein(a)
2. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
3. Evidence that Lp(a) contains one molecule of apo(a) and one molecule of apo B: Evaluation of amino acid analysis data
4. Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma
5. Ten-year follow-up results from the Goettingen Risk, Incidence and Prevalence Study (GRIPS). I. Risk factors for myocardial infarction in a cohort of 5790 men
6. Lipoprotein(a) in patients with acute cerebral ischemia
7. Turnover of lipoprotein(a) in man
8. Lipoprotein(a) is not a metabolic product of other lipoproteins containing apolipoprotein B
9. Interaction of lipoprotein Lp(a) with the B/E-receptor: A study using isolated bovine adrenal cortex and human fibroblast receptors
10. The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans
11. The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform is not due to differences in Lp(a) catabolism but to differences in production rate
12. Variation in lipoprotein(a) concentration among individuals with the same apolipoprotein(a) isoform is determined by the rate of lipoprotein(a) production
13. Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implication for apolipoprotein synthesis
14. Intracellular maturation of apolipoprotein(a) and assembly of lipoprotein(a) in primary baboon hepatocytes
15. Molecular basis for 'null' lipoprotein(a) phenotypes and the influence of apolipoprotein(a) size on plasma lipoprotein(a) level in baboon
16. Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(A)
17. 3500→Gln)
18. Expression of human apolipoproteinB 90 in transgenic mice. Demonstration that apolipoprotein B 90 lacks the structural requirements to form lipoprotein(a)
19. The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor
20. Lipoprotein(a) in renal disease
21. Renovascular arteriovenous differences in Lp(a) plasma concentrations suggest removal of Lp(a) from the renal circulation
22. A simultaneous study of the metabolism of apolipoprotein B and albumin in nephrotic patients
23. Sensitive methods to study human apolipoprotein B metabolism using stable isotope labelled amino acids
24. Quantification of lipoprotein(a) in plasma by assaying cholesterol in lectin-bound plasma fraction
25. Protein purification by affinity chromatography
26. Interaction of apolipoprotein(a) with apolipoprotein B-containing lipoproteins
27. Improved techniques for assessment of plasma lipoprotein patterns. I. Precipitation in gels after electrophoresis with polyanionic compounds
28. Abetalipoproteinemia with an apo B-100 lipoprotein (a) glycoprotein complex in plasma
29. Complete protein sequence and identification of structural domains of human apolipoprotein B
30. Effect of the number of apolipoprotein(a) kringle domains on immunochemical measurements of lipoprotein(a)
31. Determination of amino acid profiles in biological samples by gas chromatography
32. Comparative analysis of the apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups
33. Tracer-to-tracee ratio for analysis of stable isotope tracer data: Link with radioactive kinetic formalism
34. Catabolism of lipoprotein(a) in familial hypercholesterolaemic subjects
35. Cell surface assembly of lipoprotein(a) in primary cultures of baboon hepatocytes
36. De novo production of low density lipoproteins: Fact or fancy
37. HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels
38. Binding and degradation of lipoprotein(a) and LDL by primary cultures of human hepatocytes. Comparison with cultured human monocyte-macrophages and fibroblasts
39. Down-regulation of VLDL receptor expression in chronic experimental renal failure
40. Lipoprotein(a) quantification: Comparison of methods and strategies for standardisation
41. Kringle-containing fragments of apolipoprotein(a) circulate in human plasma and are excreted into the urine
42. Apolipoprotein(a) kringle 4-containing fragments in human urine: Relationship to plasma levels of lipoprotein(a)
43. Urinary excretion of apo(a) fragments. Role in apo(a) catabolism
44. Learning about the structure and biology of human lipoprotein(a) through dissection by enzymes of the elastase family: Facts and speculations