Isolation, quantitation, and characterization of a stable complex formed by Lp[a] binding to triglyceride-rich lipoproteins

Journal of Lipid Research

Volumn 42, Issue 12, 2001, Pages 2058-2068

  Gaubatz, John W ^a   Hoogeveen, Ron C ^a   Hoffman, Alan S ^a   Ghazzaly, Karima G ^a   Pownall, Henry J ^a   Guevara Jr , Juan ^a   Koschinsky, Marlys L ^b   Morrisett, Joel D ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b QUEEN S UNIVERSITY   (Canada)

^c HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Apo a ; Chylomicrons; ELISA; Hypertriglyceridemia; Type IV; Type V; VLDL

Indexed keywords

AMINOCAPROIC ACID; APOLIPOPROTEIN A; ARGININE; CHOLESTEROL; CHYLOMICRON; LIPOPROTEIN; LIPOPROTEIN A; LYSINE; PROLINE; TRANEXAMIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; ATHEROSCLEROSIS; CHEMICAL ANALYSIS; CLINICAL ARTICLE; COMPLEX FORMATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; MOLECULAR WEIGHT; PATHOPHYSIOLOGY; PHENOTYPE; PLASMAPHERESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

6-AMINOCAPROIC ACID; APOLIPOPROTEINS A; ARGININE; CHROMATOGRAPHY, GEL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYPERTRIGLYCERIDEMIA; IMMUNOBLOTTING; LIPOPROTEIN(A); LYSINE; MACROMOLECULAR SUBSTANCES; MOLECULAR WEIGHT; PLASMAPHERESIS; PROLINE; PROTEIN BINDING; TRANEXAMIC ACID; TRIGLYCERIDES; ULTRACENTRIFUGATION;

EID: 0035658321     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. A new serum type system in man: The Lp-system
2. Further studies of Lp(a) lipoprotein/pre-beta1-lipoprotein in patients with coronary heart disease
3. Lipoprotein Lp(a) and the risk for myocardial infarction
4. Human plasma lipoprotein(a)
5. Protein composition of Lp(a) lipoprotein from human plasma
6. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
7. Lipoprotein(a) and its role in atherothrombotic disease
8. Structural basis for the presumptive atherothrombogenic action of lipoprotein(a). Facts and speculations
9. Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringles 32-36 of human apolipoprotein(a)
10. Lipoprotein(a) assembly quantitative assessment of the role of apo(a) kringle IV types 2-10 in particle formation
11. Interaction of apolipoprotein(a) with apolipoprotein Bcontaining lipoproteins
12. Lipoprotein(a) binding to other apolipoprotein B containing lipoproteins
13. The binding of animal low-density lipoproteins to human apolipoprotein(a)
14. Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein(a) and that cause lipid accumulation in macrophages
15. Plasma apolipoprotein changes in the triglyceriderich lipoprotein fraction of human subjects fed a fat-rich meal
16. Plasma lipoprotein distribution of apolipoprotein(a) in the fed and fasted states
17. Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia
18. Apolipoprotein (a) is present in the triglyceride-rich fraction in type IV hypertriglyceridemia
19. Association of Lp(a) rather than integrally-bound apo(a) with triglyceride-rich lipoproteins of human subjects
20. Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia
21. Effect of hypertriglyceridemia on lipoprotein(a) serum concentrations
22. Plasma triglycerides and lipoprotein(a): Inverse relationship in a hyperlipidemic Italian population
23. Serum lipoprotein(a) levels differ in different phenotypes of primary hyperlipoproteinemia
24. Plasma Lp[a] patterns after triglyceride infusion
25. Interrelation of Lp(a) with trigycerides
26. Relationship between apo[a] isoforms and Lp[a] density in subjects with different apo[a] phenotype: A study before and after a fatty meal
27. Polymorphic forms of human apolipoprotein[a]: Inheritance and relationship of their molecular weights to plasma levels of lipoprotein [a]
28. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency
29. 2+ precipitation procedure for quantitation of high-densitylipoprotein cholesterol
30. Reagent for the enzymatic determination of serum total triglycerides with improved lipolytic efficiency
31. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
32. Effect of serum lipoprotein(a) on estimation of low-density lipoprotein cholesterol by the Friedewald formula
33. Quantitation, isolation and characterization of human lipoprotein (a)
34. Evaluation of Lp[a] and other independent risk factors for CHD in Asian Indians and their USA counterparts
35. Identification of 34 apolipoprotein(a) isoforms: Differential expression of apolipoprotein(a) alleles between american blacks and whites
36. Sequences within apolipoprotein(a) kringle IV types 6-8 bind directly to low density lipoprotein and mediate noncovalent association of apo(a) with apoB100
37. Sequences within the amino terminus of apoB100 mediate its noncovalent association with apo(a)
38. Structural domains of apolipoprotein (a) and its interaction with apolipoprotein B-100 in the lipoprotein(a) particle
39. Interaction of apolipoprotein(a) with apolipoprotein B-containing lipoprotins
40. Inhibitors for the in vitro assembly of Lp(a)
41. The binding of β2-glycoprotein-I to human serum lipoproteins
42. Novel interaction of apolipoprotein(a) with β2 glycoprotein I mediated by the kringle IV domain
43. Lipoprotein(a) reduction by N-acetyl cysteine
44. Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: A potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism
45. f 100-400 hyperglyceridemic very low density lipoproteins by the low density lipoprotein receptor pathway in normal human fibroblasts
46. 2 and other apoB containing lipoproteins with lipoprotein(a)
47. Structure and metabolism of lipoprotein (a)
48. The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor
49. Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at reoperation
50. Lipoprotein(a) in plasma, arterial wall, and thrombus from patients with aortic aneurysm