Relation between number of apolipoprotein(a) kringle 4 repeats and mobility of isoforms in agarose gel: Basis for a standardized isoform nomenclature

Clinical Chemistry

Volumn 42, Issue 3, 1996, Pages 436-439

  Marcovina, Santica M ^a,c   Hobbs, Helen H ^b   Albers, John J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NONE   (United States)

Author keywords

allelic differences; genomic blotting; genotype; phenotype; pulsed field gel electrophoresis

Indexed keywords

APOLIPOPROTEIN A;

ALLELE; ARTICLE; GENE SEQUENCE; GENOTYPE; HUMAN; IMMUNOBLOTTING; LIPOPROTEIN BLOOD LEVEL; PULSED FIELD GEL ELECTROPHORESIS; SEQUENCE ANALYSIS;

EID: 0029985439     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/42.3.436     Document Type: Article

References (13)

1. Marcovina SM, Levine DM, Lippi G. Lipoprotein(a): structure, measurement, and clinical significance. In: Rifai N, Warnick GR, eds. Laboratory measurement of lipids, lipoproteins, and apolipoproteins. Washington, DC: AACC Press, 1994:235-63.
2. McLean JW, Tomlinson JW, Kuang WJ, Eaton DL, Chen EY, Fless GM, et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 1987;330:132-7.
3. Guevara J Jr, Knapp RD, Honda S, Northup SR, Morrisett JD. A structural assessment of the apo(a) protein of human lipoprotein(a). Proteins 1992;12:188-99.
4. van der Hoek YY, Wittekoek ME, Beisiegel U, Kastelein JJ, Koschinsky ML. The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably sized isoforms. Hum Mol Genet 1993;2:361-6.
5. Lackner C, Cohen JC, Hobbs HH. Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum Mol Genet 1993;2:933-40.
6. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest 1992;90:52-60.
7. Utermann G, Menzel HJ, Kraft HG, Duba MC, Kemmler HG, Seitz C. Lp(a) glycoprotein phenotypes: inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J Clin Invest 1987;80:458-65.
8. Gaubatz JW, Ghanem KI, Guevara JJ, Nava ML, Patsch W, Morrisett JD. Polymorphic forms of human apolipoprotein(a): inheritance and relationship of their molecular weights to plasma levels of lipoprotein(a). J Lipid Res 1990;31:603-13.
9. Kamboh MI, Ferrell RE, Kottke BA. Expressed hypervariable polymorphism of apolipoprotein(a). Am J Hum Genet 1991;49:1063-74.
10. Marcovina SM, Zhang ZH, Gaur VP, Albers JJ. Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites. Biochem Biophys Res Commun 1993;191:1192-6.
11. Lackner C, Boerwinkle E, Leffert CC, Rahmig T, Hobbs HH. Molecular basis of apolipoprotein(a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis. J Clin Invest 1991; 87:2153-61.
12. Marcovina SM, Albers JJ, Gabel B, Koschinsky ML, Gaur VP. Effect of the number of apolipoprotein(a) kringle 4 domains on immunochemical measurements of lipoprotein(a). Clin Chem 1994;41: 246-55.
13. Fless GM, ZumMallen ME, Scanu AM. Physicochemical properties of apolipoprotein(a) and lipoprotein(a-) derived from the dissociation of human plasma lipoprotein(a). J Biol Chem 1986;261: 8712-8.