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Volumn 100, Issue , 2016, Pages 99-106

Second-line angiogenesis inhibition in metastatic colorectal cancer patients: Straightforward or overcrowded?

Author keywords

Aflibercept; Angiogenesis; Bevacizumab; Colorectal cancer; Ramucirumab; Second line

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; FLUOROPYRIMIDINE; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PLACENTAL GROWTH FACTOR; RAMUCIRUMAB; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 2; ANGIOGENESIS INHIBITOR; HYBRID PROTEIN; MONOCLONAL ANTIBODY; VASCULOTROPIN RECEPTOR;

EID: 84960452031     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2016.02.005     Document Type: Review
Times cited : (11)

References (50)
  • 1
    • 84940646699 scopus 로고    scopus 로고
    • Ramucirumab for colon cancer and the problem of rising prices independent of benefits
    • Bach P.B. Ramucirumab for colon cancer and the problem of rising prices independent of benefits. Oncologist 2015, 20:1-2.
    • (2015) Oncologist , vol.20 , pp. 1-2
    • Bach, P.B.1
  • 2
    • 77955123285 scopus 로고    scopus 로고
    • Effects of anti-VEGF treatment duration on tumour growth, tumour regrowth, and treatment efficacy
    • Bagri A., Berry L., Gunter B., et al. Effects of anti-VEGF treatment duration on tumour growth, tumour regrowth, and treatment efficacy. Clin. Cancer Res. 2010, 16:3887-3900.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3887-3900
    • Bagri, A.1    Berry, L.2    Gunter, B.3
  • 4
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumour vasculature and alleviates edema in glioblastoma patients
    • Batchelor T.T., Sorensen A.G., di Tomaso E., Zhang W.T., Duda D.G., Cohen K.S., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumour vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007, 11:83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3    Zhang, W.T.4    Duda, D.G.5    Cohen, K.S.6
  • 5
    • 84871536208 scopus 로고    scopus 로고
    • Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-bevacizumab or FOLFIRI-bevacizumab: results from ARIE, a bevacizumab observational cohort study
    • Bendell J.C., Bekaii-Saab T.S., Cohn A.L., et al. Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-bevacizumab or FOLFIRI-bevacizumab: results from ARIE, a bevacizumab observational cohort study. Oncologist 2012, 17:1486-1495.
    • (2012) Oncologist , vol.17 , pp. 1486-1495
    • Bendell, J.C.1    Bekaii-Saab, T.S.2    Cohn, A.L.3
  • 6
    • 84871720057 scopus 로고    scopus 로고
    • Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial
    • Bennouna J., Sastre J., Arnold D., et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol. 2013, 14:29-37.
    • (2013) Lancet Oncol. , vol.14 , pp. 29-37
    • Bennouna, J.1    Sastre, J.2    Arnold, D.3
  • 7
    • 0037967272 scopus 로고    scopus 로고
    • Tumourigenesis and the angiogenic switch
    • Berges G., Benjamin L.E. Tumourigenesis and the angiogenic switch. Nat. Rev. Cancer 2003, 3:401-410.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 401-410
    • Berges, G.1    Benjamin, L.E.2
  • 8
    • 84899089584 scopus 로고    scopus 로고
    • Vasculature analysis of patient derived tumour xenografts using species-specific PCR assays: evidence of tumour endothelial cells and atypical VEGFA-VEGFR1/2 signalings
    • (PubMed PMID: 24625025; PubMed Central PMCID: PMC4007753)
    • Bieche I., Vacher S., Vallerand D., Richon S., Hatem R., De Plater L., Dahmani A., Némati F., Angevin E., Marangoni E., Roman-Roman S., Decaudin D., Dangles-Marie V. Vasculature analysis of patient derived tumour xenografts using species-specific PCR assays: evidence of tumour endothelial cells and atypical VEGFA-VEGFR1/2 signalings. BMC Cancer 2014, 14(March):178. (PubMed PMID: 24625025; PubMed Central PMCID: PMC4007753). 10.1186/1471-2407-14-178.
    • (2014) BMC Cancer , vol.14 , Issue.MARCH , pp. 178
    • Bieche, I.1    Vacher, S.2    Vallerand, D.3    Richon, S.4    Hatem, R.5    De Plater, L.6    Dahmani, A.7    Némati, F.8    Angevin, E.9    Marangoni, E.10    Roman-Roman, S.11    Decaudin, D.12    Dangles-Marie, V.13
  • 9
    • 66149086950 scopus 로고    scopus 로고
    • Positive and negative modulation of angiogenesis by VEGFR1 ligands
    • re1
    • Cao Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci. Signal. 2009, 2:re1.
    • (2009) Sci. Signal. , vol.2
    • Cao, Y.1
  • 13
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumours without affecting healthy vessels
    • Fischer C., Jonckx B., Mazzone M., Zacchigna S., Loges S., Pattarini L., et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumours without affecting healthy vessels. Cell 2007, 131:463-475.
    • (2007) Cell , vol.131 , pp. 463-475
    • Fischer, C.1    Jonckx, B.2    Mazzone, M.3    Zacchigna, S.4    Loges, S.5    Pattarini, L.6
  • 14
    • 85015497707 scopus 로고    scopus 로고
    • Clinical advances in the development of novel VEGFR2 inhibitors
    • Fontanella C., Ongaro E., Bonzonello S., et al. Clinical advances in the development of novel VEGFR2 inhibitors. Ann. Transl. Med. 2014, 2(12):123.
    • (2014) Ann. Transl. Med. , vol.2 , Issue.12 , pp. 123
    • Fontanella, C.1    Ongaro, E.2    Bonzonello, S.3
  • 15
    • 84892852372 scopus 로고    scopus 로고
    • Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomized, multicentre, placebo-controlled phase 3 trial
    • Fuchs C.S., Tomasek J., Yong C.J., et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomized, multicentre, placebo-controlled phase 3 trial. Lancet 2014, 383:31-39.
    • (2014) Lancet , vol.383 , pp. 31-39
    • Fuchs, C.S.1    Tomasek, J.2    Yong, C.J.3
  • 16
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial
    • Garon E.B., Ciuleanu T.-E., Arrieta O., et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 2014, 384:665-673.
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.-E.2    Arrieta, O.3
  • 17
    • 84861190138 scopus 로고    scopus 로고
    • A preclinical and clinical review of aflibercept for the management of cancer
    • Gaya A., Tse V. A preclinical and clinical review of aflibercept for the management of cancer. Cancer Treat. Rev. 2012, 38:484-493.
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 484-493
    • Gaya, A.1    Tse, V.2
  • 18
    • 84904797990 scopus 로고    scopus 로고
    • The angiogenetic ladder, step-wise angiogenesis inhibition in metastatic colorectal cancer
    • (Epub 2014 Jun 20. PubMed PMID: 24997679.)
    • Giampieri R., Scartozzi M., Del Prete M., Fulli A., Faloppi L., Bianconi M., Maccaroni E., Cascinu S. The angiogenetic ladder, step-wise angiogenesis inhibition in metastatic colorectal cancer. Cancer Treat. Rev. 2014, 40(September (8)):934-941. (Epub 2014 Jun 20. PubMed PMID: 24997679.). 10.1016/j.ctrv.2014.06.004.
    • (2014) Cancer Treat. Rev. , vol.40 , pp. 934-941
    • Giampieri, R.1    Scartozzi, M.2    Del Prete, M.3    Fulli, A.4    Faloppi, L.5    Bianconi, M.6    Maccaroni, E.7    Cascinu, S.8
  • 19
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio B.J., Catalano P.J., Meropol N.J., et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J. Clin. Oncol. 2007, 25:1539-1544.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 20
    • 68549092863 scopus 로고    scopus 로고
    • Targetedtherapies: Goldie-Coldman and bevacizumab beyond disease progression
    • Giantonio B.J. Targetedtherapies: Goldie-Coldman and bevacizumab beyond disease progression. Nat. Rev. Clin. Oncol. 2009, 6:311-312.
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 311-312
    • Giantonio, B.J.1
  • 21
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE)
    • Grothey A., Sugrue M.M., Purdie D.M., et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J. Clin. Oncol. 2008, 26:5326-5334.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 23
    • 26444484355 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumour and ascites, prolonging survival in a human ovarian cancer model
    • Hu L., Hofmann J., Holash J., Yancopoulos G.D., Sood A.K., Jaffe R.B. Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumour and ascites, prolonging survival in a human ovarian cancer model. Clin. Cancer Res. 2005, 11:6966-6971.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6966-6971
    • Hu, L.1    Hofmann, J.2    Holash, J.3    Yancopoulos, G.D.4    Sood, A.K.5    Jaffe, R.B.6
  • 24
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer. NEJM 2004, 350(23):2335-2342.
    • (2004) NEJM , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 25
    • 84946728807 scopus 로고    scopus 로고
    • FOLFIRI plus bevacizumab as second-line therapy in patients with metastatic colorectal cancer after first-line bevacizumab plus oxaliplatin-based therapy: the randomized phase III EAGLE study
    • Iwamoto S., Takahashi T., Tamagawa H., et al. FOLFIRI plus bevacizumab as second-line therapy in patients with metastatic colorectal cancer after first-line bevacizumab plus oxaliplatin-based therapy: the randomized phase III EAGLE study. Ann. Oncol. 2015, 26:1427-1433.
    • (2015) Ann. Oncol. , vol.26 , pp. 1427-1433
    • Iwamoto, S.1    Takahashi, T.2    Tamagawa, H.3
  • 26
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • (Epub 2009 Dec 14)
    • Kopetz S., Hoff P.M., Morris J.S., Wolff R.A., Eng C., Glover K.Y., Adinin R., Overman M.J., Valero V., Wen S., Lieu C., Yan S., Tran H.T., Ellis L.M., Abbruzzese J.L., Heymach J.V. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J. Clin. Oncol. 2010, 28(January (3)):453-459. (Epub 2009 Dec 14). 10.1200/JCO.2009.24.8252.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.JANUARY 3 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3    Wolff, R.A.4    Eng, C.5    Glover, K.Y.6    Adinin, R.7    Overman, M.J.8    Valero, V.9    Wen, S.10    Lieu, C.11    Yan, S.12    Tran, H.T.13    Ellis, L.M.14    Abbruzzese, J.L.15    Heymach, J.V.16
  • 27
    • 84883381780 scopus 로고    scopus 로고
    • Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings
    • Kubicka S., Greil R., André T., et al. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings. Ann. Oncol. 2013, 24:2342-2349.
    • (2013) Ann. Oncol. , vol.24 , pp. 2342-2349
    • Kubicka, S.1    Greil, R.2    André, T.3
  • 28
    • 84926476833 scopus 로고    scopus 로고
    • Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: final results of the randomized BEBYP trial
    • Masi G., Salvatore L., Boni L., et al. Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: final results of the randomized BEBYP trial. Ann. Oncol. 2015, 26:724-730.
    • (2015) Ann. Oncol. , vol.26 , pp. 724-730
    • Masi, G.1    Salvatore, L.2    Boni, L.3
  • 29
    • 84904987878 scopus 로고    scopus 로고
    • Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor
    • Mesange P., Poindesseous V., Sabbah M., et al. Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Oncotarget 2013, 5(October (13)):4709-4720.
    • (2013) Oncotarget , vol.5 , Issue.OCTOBER 13 , pp. 4709-4720
    • Mesange, P.1    Poindesseous, V.2    Sabbah, M.3
  • 31
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., Michaelson M.D., Redman B.G., Hudes G.R., Wilding G., Figlin R.A., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 2006, 24:16-24.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3    Hudes, G.R.4    Wilding, G.5    Figlin, R.A.6
  • 32
    • 84868584808 scopus 로고    scopus 로고
    • Phase 2 randomized, noncomparative open-label study of aflibercept and modified FOLFOX6 in the first line treatment of metastatic colorectal cancer (AFFIRM): Abstract O-0024
    • Pericay C.F.G., Saunders M., Thomas A., Roh J.K., Lopez R., et al. Phase 2 randomized, noncomparative open-label study of aflibercept and modified FOLFOX6 in the first line treatment of metastatic colorectal cancer (AFFIRM): Abstract O-0024. Ann. Oncol. 2012, 23(Suppl. 4):iv5-18.
    • (2012) Ann. Oncol. , vol.23 , pp. iv5-18
    • Pericay, C.F.G.1    Saunders, M.2    Thomas, A.3    Roh, J.K.4    Lopez, R.5
  • 33
    • 36749040908 scopus 로고    scopus 로고
    • VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
    • Rudge J.S., Holash J., Hylton D., Russell M., Jiang S., Leidich R., et al. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:18363-18370.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 18363-18370
    • Rudge, J.S.1    Holash, J.2    Hylton, D.3    Russell, M.4    Jiang, S.5    Leidich, R.6
  • 34
    • 84857790397 scopus 로고    scopus 로고
    • Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients
    • (Epub 2012 Feb 7. PubMed PMID: 22315053; PubMed Central PMCID: PMC3305976.)
    • Scartozzi M., Giampieri R., Maccaroni E., Del Prete M., Faloppi L., Bianconi M., Galizia E., Loretelli C., Belvederesi L., Bittoni A., Cascinu S. Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients. Br. J. Cancer 2012, 106(February (5)):799-804. (Epub 2012 Feb 7. PubMed PMID: 22315053; PubMed Central PMCID: PMC3305976.). 10.1038/bjc.2012.17.
    • (2012) Br. J. Cancer , vol.106 , Issue.FEBRUARY 5 , pp. 799-804
    • Scartozzi, M.1    Giampieri, R.2    Maccaroni, E.3    Del Prete, M.4    Faloppi, L.5    Bianconi, M.6    Galizia, E.7    Loretelli, C.8    Belvederesi, L.9    Bittoni, A.10    Cascinu, S.11
  • 35
    • 84858855476 scopus 로고    scopus 로고
    • The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management
    • (Epub 2012 Mar 26. PubMed PMID: 22461886; PubMedCentral PMCID: PMC3312882.)
    • Scartozzi M., Faloppi L., Bianconi M., Giampieri R., Maccaroni E., Bittoni A., Del Prete M., Loretelli C., Belvederesi L., Svegliati Baroni G., Cascinu S. The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management. PLoS One 2012, 7(3):e32653. (Epub 2012 Mar 26. PubMed PMID: 22461886; PubMedCentral PMCID: PMC3312882.). 10.1371/journal.pone.0032653.
    • (2012) PLoS One , vol.7 , Issue.3 , pp. e32653
    • Scartozzi, M.1    Faloppi, L.2    Bianconi, M.3    Giampieri, R.4    Maccaroni, E.5    Bittoni, A.6    Del Prete, M.7    Loretelli, C.8    Belvederesi, L.9    Svegliati Baroni, G.10    Cascinu, S.11
  • 37
    • 84860130221 scopus 로고    scopus 로고
    • Anti-VEGF/VEGFR therapy for cancer: reassessing the target
    • (Review.PubMedPMID:22508695;PubMedCentralPMCID:PMC3335750)
    • Sitohy B., Nagy J.A., Dvorak H.F. Anti-VEGF/VEGFR therapy for cancer: reassessing the target. Cancer Res. 2012, 72(April (8)):1909-1914. (Review.PubMedPMID:22508695;PubMedCentralPMCID:PMC3335750). 10.1158/0008-5472.CAN-11-3406.
    • (2012) Cancer Res. , vol.72 , Issue.APRIL 8 , pp. 1909-1914
    • Sitohy, B.1    Nagy, J.A.2    Dvorak, H.F.3
  • 38
    • 79955798791 scopus 로고    scopus 로고
    • Ramucirumab (IMC-1121B) monoclonal antibody inhibition of vascular endothelial growth factor receptor-2
    • Spratlin J. Ramucirumab (IMC-1121B) monoclonal antibody inhibition of vascular endothelial growth factor receptor-2. Curr. Oncol. Rep. 2011, 13(2):97-102.
    • (2011) Curr. Oncol. Rep. , vol.13 , Issue.2 , pp. 97-102
    • Spratlin, J.1
  • 39
    • 84891831211 scopus 로고    scopus 로고
    • Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial
    • Tabernero J., Van Cutsem E., Lakomy R., Prausová J., Ruff P., van Hazel G.A., et al. Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial. Eur. J. Cancer 2014, 50:320-331.
    • (2014) Eur. J. Cancer , vol.50 , pp. 320-331
    • Tabernero, J.1    Van Cutsem, E.2    Lakomy, R.3    Prausová, J.4    Ruff, P.5    van Hazel, G.A.6
  • 40
    • 84933673498 scopus 로고    scopus 로고
    • Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study
    • Tabernero J., Yoshino T., Cohn A.L., et al. Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study. Lancet Oncol. 2015, 16(5):499-508.
    • (2015) Lancet Oncol. , vol.16 , Issue.5 , pp. 499-508
    • Tabernero, J.1    Yoshino, T.2    Cohn, A.L.3
  • 41
    • 84868527016 scopus 로고    scopus 로고
    • Phase II clinical and pharmacokinetic study of aflibercept in patients with previously treated metastatic colorectal cancer
    • Tang P., Cohen S.J., Kollmannsberger C., Bjarnason G., Virik K., Mackenzie M.J., et al. Phase II clinical and pharmacokinetic study of aflibercept in patients with previously treated metastatic colorectal cancer. Clin. Cancer Res. 2012, 18:6023-6031.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6023-6031
    • Tang, P.1    Cohen, S.J.2    Kollmannsberger, C.3    Bjarnason, G.4    Virik, K.5    Mackenzie, M.J.6
  • 43
    • 33646227448 scopus 로고    scopus 로고
    • Synergistic antitumour effect of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy
    • Tonra J.R., Deevi D.S., Corcoran E., et al. Synergistic antitumour effect of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy. Clin. Cancer Res. 2006, 12:2197-2207.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2197-2207
    • Tonra, J.R.1    Deevi, D.S.2    Corcoran, E.3
  • 44
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E., Tabernero J., Lakomy R., Prenen H., Prausova J., Macarulla T., et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J. Clin. Oncol. 2012, 30:3499-3506.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3    Prenen, H.4    Prausova, J.5    Macarulla, T.6
  • 45
    • 84871448485 scopus 로고    scopus 로고
    • Phase I Dose-escalation study of intravenous aflibercept administered in combination with irinotecan, 5-fluorouracil and leucovorin in patients with advanced solid tumours
    • Van Cutsem E., Khayat D., Verslype C., Billemont B., Tejpar S., Meric J.B., et al. Phase I Dose-escalation study of intravenous aflibercept administered in combination with irinotecan, 5-fluorouracil and leucovorin in patients with advanced solid tumours. Eur. J. Cancer 2013, 49:17-24.
    • (2013) Eur. J. Cancer , vol.49 , pp. 17-24
    • Van Cutsem, E.1    Khayat, D.2    Verslype, C.3    Billemont, B.4    Tejpar, S.5    Meric, J.B.6
  • 46
    • 77950960449 scopus 로고    scopus 로고
    • Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
    • Van de Veire S., Stalmans I., Heindryckx F., Oura H., Tijeras-Raballand A., Schmidt T., et al. Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell 2010, 141:178-190.
    • (2010) Cell , vol.141 , pp. 178-190
    • Van de Veire, S.1    Stalmans, I.2    Heindryckx, F.3    Oura, H.4    Tijeras-Raballand, A.5    Schmidt, T.6
  • 47
    • 84908139963 scopus 로고    scopus 로고
    • Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomized, phase 3 trial
    • Wilke H., Muro K., van Cutsem E., et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomized, phase 3 trial. Lancet Oncol. 2014, 15:1224-1235.
    • (2014) Lancet Oncol. , vol.15 , pp. 1224-1235
    • Wilke, H.1    Muro, K.2    van Cutsem, E.3
  • 48
    • 84877673601 scopus 로고    scopus 로고
    • Colorectal cancer cells refractory to anti-VEGF treatment are vulnerable to glycolytic blockade due to persistent impairment of mitochondria
    • (MCT-12-1016-T. Epub 2013 Feb 20. PubMed PMID: 23427299.)
    • Xu J., Wang J., Xu B., Ge H., Zhou X., Fang J.Y. Colorectal cancer cells refractory to anti-VEGF treatment are vulnerable to glycolytic blockade due to persistent impairment of mitochondria. Mol. Cancer Ther. 2013, 12(May (5)):717-724. (MCT-12-1016-T. Epub 2013 Feb 20. PubMed PMID: 23427299.). 10.1158/1535-7163.
    • (2013) Mol. Cancer Ther. , vol.12 , Issue.MAY 5 , pp. 717-724
    • Xu, J.1    Wang, J.2    Xu, B.3    Ge, H.4    Zhou, X.5    Fang, J.Y.6
  • 49
    • 84977875974 scopus 로고    scopus 로고
    • Antiangiogenic therapy impedes infiltration by CD4+ and CD8+ cells into an early colon tumour
    • Yang Yoon Jung, Choi Joon-Seok, Choi Jin Woo Antiangiogenic therapy impedes infiltration by CD4+ and CD8+ cells into an early colon tumour. J. Cancer Prev. 2015, 20:129-135.
    • (2015) J. Cancer Prev. , vol.20 , pp. 129-135
    • Yang, Y.J.1    Choi, J.-S.2    Choi, J.W.3
  • 50
    • 79960984152 scopus 로고    scopus 로고
    • Expression of a functional VEGFR-1 in tumour cells is a major determinant of anti-PlGF antibodies efficacy
    • Yao J., Wu X., Kasman I.M., Vogt T., Phan V., Shibuya M., et al. Expression of a functional VEGFR-1 in tumour cells is a major determinant of anti-PlGF antibodies efficacy. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:11590-11595.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 11590-11595
    • Yao, J.1    Wu, X.2    Kasman, I.M.3    Vogt, T.4    Phan, V.5    Shibuya, M.6


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