Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor

Oncotarget

Volumn 5, Issue 13, 2014, Pages 4709-4721

  Mésange, Paul ^a,b,c,d   Poindessous, Virginie ^a,b,c   Sabbah, Michèle ^a,b,c   Escargueil, Alexandre E ^a,b,c   de Gramont, Aimery ^a,b,c,e   Larsen, Annette K ^a,b,c  

^a CENTRE DE RECHERCHE SAINT ANTOINE   (France)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e HÔPITAL SAINT ANTOINE   (France)

Author keywords

Angiogenesis inhibition; Bevacizumab; Hypoxia; Ninte danib; Resistance; Vascular endothelial growth factor (VEGF) signaling

Indexed keywords

BEVACIZUMAB; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NINTEDANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; ANGIOGENESIS INHIBITOR; ENZYME INHIBITOR; HIF1A PROTEIN, HUMAN; INDOLE DERIVATIVE; MOLECULAR LIBRARY; MONOCLONAL ANTIBODY; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOCRINE EFFECT; CANCER GROWTH; CANCER INHIBITION; CANCER RESISTANCE; CELL CYCLE ARREST; CELL HYPOXIA; CELL SURVIVAL; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; CYTOSTASIS; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HT 29 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; LOW DRUG DOSE; MOUSE; NONHUMAN; PHYSICAL TOLERANCE; PROTEIN EXPRESSION; TREATMENT OUTCOME; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ANIMAL; ANOXIA; ANTAGONISTS AND INHIBITORS; COLORECTAL NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ENZYMOLOGY; GENETICS; INBRED MOUSE STRAIN; METABOLISM; MOLECULAR LIBRARY; NEOVASCULARIZATION, PATHOLOGIC; NUDE MOUSE; PHARMACOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANGIOGENESIS INHIBITORS; ANIMALS; ANOXIA; ANTIBODIES, MONOCLONAL, HUMANIZED; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENZYME INHIBITORS; HT29 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDOLES; MICE, INBRED STRAINS; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84904987878     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1671     Document Type: Article

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