Effects of cellular pathway disturbances on misfolded superoxide dismutase-1 in fibroblasts derived from ALS patients

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Keskin, Isil ^a   Forsgren, Elin ^a   Lange, Dale J ^b   Weber, Markus ^c   Birve, Anna ^a   Synofzik, Matthis ^d,e   Gilthorpe, Jonathan D ^a   Andersen, Peter M ^a   Marklund, Stefan L ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GENOMIC DNA; PROTEASOME; UBIQUITIN; 3-METHYLADENINE; ADENINE; BORTEZOMIB; C9ORF72 PROTEIN, HUMAN; PROTEIN; PROTEINASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REPETITIVE DNA; ROTENONE; SOD1 PROTEIN, HUMAN; SUPEROXIDE DISMUTASE;

AGING; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPHAGY; C9ORF72 GENE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; GENE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; MISSENSE MUTATION; MITOCHONDRIAL RESPIRATION; MOLECULAR PATHOLOGY; NEUROTOXICITY; NUCLEOTIDE REPEAT; ONSET AGE; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MISFOLDING; PROTEIN STRUCTURE; SKIN FIBROBLAST; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; FIBROBLAST; GENETICS; GENOTYPE; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; PROTEIN FOLDING; PROTEINOSIS; SOLUBILITY;

ADENINE; AGE OF ONSET; AGING; AMYOTROPHIC LATERAL SCLEROSIS; AUTOPHAGY; BORTEZOMIB; CASE-CONTROL STUDIES; CELLS, CULTURED; DNA REPEAT EXPANSION; ELECTRON TRANSPORT COMPLEX I; ENDOPLASMIC RETICULUM STRESS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENOTYPE; HUMANS; MUTATION; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN FOLDING; PROTEINS; PROTEOLYSIS; ROTENONE; SOLUBILITY; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE-1;

EID: 84960420328     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0150133     Document Type: Article

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