Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line

Metabolism: Clinical and Experimental

Volumn 65, Issue 4, 2016, Pages 522-532

  Saito, Kenji ^a   He, Yanlin ^a   Yan, Xiaofeng ^a   Yang, Yongjie ^a   Wang, Chunmei ^a   Xu, Pingwen ^a   Hinton, Antentor Othrell ^a   Shu, Gang ^a   Yu, Likai ^a   Tong, Qingchun ^b   Xu, Yong ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Brain; Electrophysiology; Estrogen receptor ; Transgenic mouse

Indexed keywords

ESTROGEN RECEPTOR ALPHA; GREEN FLUORESCENT PROTEIN; PROTEIN ZSGREEN; UNCLASSIFIED DRUG; ERRALPHA ESTROGEN-RELATED RECEPTOR; ESTROGEN RECEPTOR; MESSENGER RNA; PROOPIOMELANOCORTIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BRAIN ELECTROPHYSIOLOGY; BRAIN TISSUE; CONTROLLED STUDY; FEMALE; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MALE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANIMAL; BIOSYNTHESIS; BRAIN CHEMISTRY; C57BL MOUSE; CELL LINE; CELL SEPARATION; CYTOLOGY; ELECTROPHYSIOLOGY; GENETICS; METABOLISM; PROCEDURES; REPORTER GENE; ULTRASTRUCTURE;

ALLELES; ANIMALS; ARCUATE NUCLEUS OF HYPOTHALAMUS; BRAIN CHEMISTRY; CELL LINE; CELL SEPARATION; ELECTROPHYSIOLOGICAL PHENOMENA; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; MICE; MICE, INBRED C57BL; NEURONS; PRO-OPIOMELANOCORTIN; RECEPTORS, ESTROGEN; RNA, MESSENGER;

EID: 84960410631     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.12.011     Document Type: Article

References (36)

1. M.M. McCarthy Estradiol and the developing brain Physiol Rev 88 2008 91 124
2. S.L. Dubois, M. Acosta-Martinez, M.R. DeJoseph, and et al. Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor alpha in kisspeptin neurons Endocrinology 156 2015 1111 1120
3. T.M. Wintermantel, R.E. Campbell, R. Porteous, and et al. Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility Neuron 52 2006 271 280
4. H. Lee, D.W. Kim, R. Remedios, and et al. Scalable control of mounting and attack by Esr1 neurons in the ventromedial hypothalamus Nature 2014
5. E.J. Spary, A. Maqbool, and T.F. Batten Oestrogen receptors in the central nervous system and evidence for their role in the control of cardiovascular function J Chem Neuroanat 38 2009 185 196
6. Y. Hara, E.M. Waters, B.S. McEwen, and et al. Estrogen effects on cognitive and synaptic health over the lifecourse Physiol Rev 95 2015 785 807
7. K. Saito, X. Cao, Y. He, and et al. Progress in the molecular understanding of central regulation of body weight by estrogens Obesity (Silver Spring) 23 2015 919 926
8. A. Frank, L.M. Brown, and D.J. Clegg The role of hypothalamic estrogen receptors in metabolic regulation Front Neuroendocrinol 35 2014 550 557
9. M.H. Faulds, C. Zhao, K. Dahlman-Wright, and et al. The diversity of sex steroid action: Regulation of metabolism by estrogen signaling J Endocrinol 212 2012 3 12
10. P.C. Butera, and R.J. Beikirch Central implants of diluted estradiol: Independent effects on ingestive and reproductive behaviors of ovariectomized rats Brain Res 491 1989 266 273
11. K. Palmer, and J.M. Gray Central vs. peripheral effects of estrogen on food intake and lipoprotein lipase activity in ovariectomized rats Physiol Behav 37 1986 187 189
12. Y. Xu, T.P. Nedungadi, L. Zhu, and et al. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction Cell Metab 14 2011 453 465
13. X. Cao, P. Xu, M.G. Oyola, and et al. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice J Clin Invest 124 2014 4351 4362
14. L. Asarian, and N. Geary Estradiol enhances cholecystokinin-dependent lipid-induced satiation and activates estrogen receptor-alpha-expressing cells in the nucleus tractus solitarius of ovariectomized rats Endocrinology 148 2007 5656 5666
15. M.d.M. PB, I. Gonzalez-Garcia, L. Martins, and et al. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK Cell Metab 20 2014 41 53
16. S. Musatov, W. Chen, D.W. Pfaff, and et al. Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome Proc Natl Acad Sci USA 104 2007 2501 2506
17. S.M. Correa, D.W. Newstrom, J.P. Warne, and et al. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females Cell Rep 10 2015 62 74
18. P. Xu, X. Cao, Y. He, and et al. Estrogen receptor-alpha in medial amygdala neurons regulates body weight J Clin Invest 125 2015 2861 2876
19. C.J. Park, Z. Zhao, C. Glidewell-Kenney, and et al. Genetic rescue of nonclassical ERalpha signaling normalizes energy balance in obese ERalpha-null mutant mice J Clin Invest 121 2011 604 612
20. L. Zhu, F. Zou, Y. Yang, and et al. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice Endocrinology 156 2015 2114 2123
21. R. Frazao, R.M. Cravo, J. Donato Jr., and et al. Shift in Kiss1 cell activity requires estrogen receptor alpha J Neurosci 33 2013 2807 2820
22. E.D. Berglund, C. Liu, J.W. Sohn, and et al. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis J Clin Invest 123 2013 5061 5070
23. L. Madisen, T.A. Zwingman, S.M. Sunkin, and et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain Nat Neurosci 13 2010 133 140
24. A.R. Kay, and R.K. Wong Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems J Neurosci Methods 16 1986 227 238
25. S.R. Stauffer, C.J. Coletta, R. Tedesco, and et al. Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists J Med Chem 43 2000 4934 4947
26. J.W. Sohn, L.E. Harris, E.D. Berglund, and et al. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons Cell 152 2013 612 619
27. Y. Liu, H. Liu, C. Sauvey, and et al. Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells Nat Protoc 8 2013 1670 1679
28. T. Liu, D. Kong, B.P. Shah, and et al. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone Neuron 73 2012 511 522
29. I. Merchenthaler, M.V. Lane, S. Numan, and et al. Distribution of estrogen receptor alpha and beta in the mouse central nervous system: In vivo autoradiographic and immunocytochemical analyses J Comp Neurol 473 2004 270 291
30. T. Hamada, Y. Wada-Kiyama, and Y. Sakuma Visualizing forebrain-specific usage of an estrogen receptor alpha promoter for receptor downregulation in the rat Brain Res Mol Brain Res 139 2005 42 51
31. K.I. Matsuda, M. Yanagisawa, K. Sano, and et al. Visualisation and characterisation of oestrogen receptor alpha-positive neurons expressing green fluorescent protein under the control of the oestrogen receptor alpha promoter Eur J Neurosci 38 2013 2242 2249
32. H. Lee, D.W. Kim, R. Remedios, and et al. Scalable control of mounting and attack by Esr1 + neurons in the ventromedial hypothalamus Nature 509 2014 627 632
33. M. Yokosuka, H. Okamura, and S. Hayashi Postnatal development and sex difference in neurons containing estrogen receptor-alpha immunoreactivity in the preoptic brain, the diencephalon, and the amygdala in the rat J Comp Neurol 389 1997 81 93
34. P.J. Shughrue, C.D. Bushnell, and D.M. Dorsa Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: A comparison with ovariectomized females and intact males Endocrinology 131 1992 381 388
35. H. Ren, I.J. Orozco, Y. Su, and et al. FoxO1 target Gpr17 activates AgRP neurons to regulate food intake Cell 149 2012 1314 1326
36. F.E. Henry, K. Sugino, A. Tozer, and et al. Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss Elife 4 2015 10.7554/eLife.09800