Visualizing forebrain-specific usage of an estrogen receptor α promoter for receptor downregulation in the rat

Molecular Brain Research

Volumn 139, Issue 1, 2005, Pages 42-51

  Hamada, Tomohiro ^a   Wada Kiyama, Yuko ^a   Sakuma, Yasuo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Downregulation; Estrogen receptor; Green fluorescent protein; Preoptic area; Promoter; Transgenic rat

Indexed keywords

ESTROGEN RECEPTOR ALPHA; GREEN FLUORESCENT PROTEIN;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FOREBRAIN; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARIECTOMY; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE; ZYGOTE;

ANIMALIA; MUS MUSCULUS; RATTUS NORVEGICUS; TERMINALIS;

EID: 27744531948     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2005.05.019     Document Type: Article

References (56)

1. S.A. Bayer, J. Altman, Neurogenesis and neuromigration, in: G. Paxinos (Ed.), The Rat Nervous System, 2nd ed., Academic Press, San Diego, CA, 1995, pp. 1041-1098.
2. C. Beyer, J. Pawlak, M. Karolczak, Membrane receptors for oestrogen in the brain, J. Neurochem. 87 (2003) 545-550.
3. J.D. Blaustein, M.N. Lehman, J.C. Turcotte, G. Greene, Estrogen receptors in dendrites and axon terminals in the guinea pig hypothalamus, Endocrinology 131 (1992) 281-290.
4. E. Choleris, J.A. Gustafsson, K.S. Korach, L.J. Muglia, D.W. Pfaff, S. Ogawa, An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-α and -β knockout mice, Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6192-6197.
5. L.L. Doncarlos, K. Malik, J.I. Morrell, Region-specific effects of ovarian hormones on estrogen receptor immunoreactivity, NeuroReport 6 (1995) 2054-2058.
6. G. Flouriot, C. Griffin, M. Kenealy, V. Sonntag-Buck, F. Gannon, Differentially expressed messenger RNA isoforms of the human estrogen receptor-α gene are generated by alternative splicing and promoter usage, Mol. Endocrinol. 12 (1998) 1939-1954.
7. B. Freyschuss, K. Grandien, The 5′ flank of the rat estrogen receptor gene: structural characterization and evidence for tissue- and species-specific promoter utilization, J. Mol. Endocrinol. 17 (1996) 197-206.
8. S.A. Hart, J.D. Patton, C.S. Woolley, Quantitative analysis of ER alpha and GAD colocalization in the hippocampus of the adult female rat, J. Comp. Neurol. 440 (2001) 144-155.
9. T. Hasegawa, Y. Sakuma, Developmental effect of testosterone on estrogen sensitivity of the rat preoptic neurons with axons to the ventral tegmental area, Brain Res. 611 (1993) 1-6.
10. S. Hirata, T. Koh, N. Yamada-Mouri, K. Hoshi, J. Kato, The untranslated first exon 'exon 0S' of the rat estrogen receptor (ER) gene, FEBS Lett. 394 (1996) 371-373.
11. S. Hirata, T. Koh, N. Yamada-Mouri, J. Kato, The novel untranslated first exon "exon ON" of the rat estrogen receptor gene, Biochem. Biophys. Res. Commun. 225 (1996) 849-854.
12. J. Kato, S. Hirata, T. Koh, N. Yamada-Mouri, K. Hoshi, S. Okinaga, The multiple untranslated first exons and promoters system of the oestrogen receptor gene in the brain and peripheral tissues of the rat and monkey and the developing rat cerebral cortex, J. Steroid Biochem. Mol. Biol. 65 (1998) 281-293.
13. M. Kato, K. Ui-Tei, M. Watanabe, Y. Sakuma, Characterization of voltage-gated calcium currents in gonadotropin-releasing hormone neurons tagged with green fluorescent protein in rats, Endocrinology 144 (2003) 5118-5125.
14. M.J. Kelly, E.R. Levin, Rapid actions of plasma membrane estrogen receptors, Trends Endocrinol. Metab. 12 (2001) 152-156.
15. Y. Kondo, T. Sudo, K. Tomihara, Y. Sakuma, Activation of accessory olfactory bulb neurons during copulatory behavior after deprivation of vomeronasal inputs in male rats, Brain Res. 962 (2003) 232-236.
16. M. Kos, G. Reid, S. Denger, F. Gannon, Genomic organization of the human ERα gene promoter region, Mol. Endocrinol. 15 (2001) 2057-2063.
17. M. Kos, S. Denger, G. Reid, F. Gannon, Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha, J. Biol. Chem. 277 (2002) 37131-37138.
18. G.G. Kuiper, P.J. Shughrue, I. Merchenthaler, J.A. Gustafsson, The estrogen receptor β subtype: a novel mediator of estrogen action in neuroendocrine systems, Front. Neuroendocrinol. 19 (1998) 253-286.
19. E.R. Levin, Cellular functions of plasma membrane estrogen receptors, Steroids 67 (2002) 471-475.
20. L. Li, M.P. Haynes, J.R. Bender, Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells, Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 4807-4812.
21. B.S. McEwen, S.E. Alves, Estrogen actions in the central nervous system, Endocr. Rev. 20 (1999) 279-307.
22. M.Y. McGinnis, L.C. Krey, N.J. Maclusky, B.S. McEwen, Steroid receptor levels in intact and ovariectomized estrogen-treated rats: an examination of quantitative, temporal and endocrine factors influencing the efficacy of an estradiol stimulus, Neuroendocrinology 33 (1981) 158-165.
23. D.D. Murphy, N.B. Cole, V. Greenberger, M. Segal, Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons, J. Neurosci. 18 (1998) 2550-2559.
24. S. Ogawa, V. Eng, J. Taylor, D.B. Lubahn, K.S. Korach, D.W. Pfaff, Roles of estrogen receptor-α gene expression in reproduction-related behaviors in female mice, Endocrinology 139 (1998) 5070-5081.
25. J.A. O'Keefe, R.J. Handa, Transient elevation of estrogen receptors in the neonatal rat hippocampus, Dev. Brain Res. 57 (1990) 119-127.
26. C. Orikasa, Y. Sakuma, Sex and region-specific regulation of oestrogen receptor beta in the rat hypothalamus, J. Neuroendocrinol. 16 (2004) 964-969.
27. C. Orikasa, K. Mizuno, Y. Sakuma, S. Hayashi, Exogenous estrogen acts differently on production of estrogen receptor in the preoptic area and the mediobasal hypothalamic nuclei in the newborn rat, Neurosci. Res. 25 (1996) 247-254.
28. C. Orikasa, Y. Kondo, S. Hayashi, B.S. McEwen, Y. Sakuma, Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge, Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 3306-3311.
29. M.K. Osterlund, K. Grandien, E. Keller, Y.L. Hurd, The human brain has distinct regional expression patterns of estrogen receptor α mRNA isoforms derived from alternative promoters, J. Neurochem. 75 (2000) 1390-1397.
30. D. Pareto, M. Alvarado, S.M. Hanrahan, A. Biegon, In vivo occupancy of female rat brain estrogen receptors by 17β-estradiol and tamoxifen, Neuroimage 23 (2004) 1161-1167.
31. I.S. Parhar, T. Soga, S. Ogawa, S. Ogawa, D.W. Pfaff, Y. Sakuma, Nonmammalian forms of gonadotropin-releasing hormone molecules in the brain of promoter transgenic rats, Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 2204-2209.
32. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 4th ed., Academic Press, San Diego, CA, 1998.
33. S.E. Perez, E.Y. Chen, E.J. Mufson, Distribution of estrogen receptor α and β immunoreactive profiles in the postnatal rat brain, Dev. Brain Res. 145 (2003) 117-139.
34. D. Pfaff, M. Keiner, Atlas of estradiol-concentrating cells in the central nervous system of the female rat, J. Comp. Neurol. 151 (1973) 121-158.
35. D.W. Pfaff, S. Schwartz-Giblin, M.M. McCarthy, L.-M. Kow, Cellular and molecular mechanisms of female reproductive behaviors, in: E. Knobil, J.D. Neill (Eds.), The Physiology of Reproduction, vol. 2, Raven Press, New York, 1994, pp. 107-220.
36. J. Prange-Kiel, U. Wehrenberg, H. Jarry, G.M. Rune, Para/autocrine regulation of estrogen receptors in hippocampal neurons, Hippocampus 13 (2003) 226-234.
37. M. Razandi, P. Oh, A. Pedram, J. Schnitzer, E.R. Levin, ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions, Mol. Endocrinol. 16 (2002) 100-115.
38. A. Rodriguez del Castillo, E. Battaner, M. Guerra, T. Alonso, M. Mas, Regional changes of brain Na+, K+-transporting adenosine triphosphatase related to ovarian function, Brain Res. 416 (1987) 113-118.
39. C.N. Rudick, R.B. Gibbs, C.S. Woolley, A role for the basal forebrain cholinergic system in estrogen-induced disinhibition of hippocampal pyramidal cells, J. Neurosci. 23 (2003) 4479-4490.
40. G.M. Rune, U. Wehrenberg, J. Prange-Kiel, L. Zhou, G. Adelmann, M. Frotscher, Estrogen up-regulates estrogen receptor α and synaptophysin in slice cultures of rat hippocampus, Neuroscience 113 (2002) 167-175.
41. Y. Sakuma, Influences of neonatal gonadectomy or androgen exposure on the sexual differentiation of the rat ventromedial hypothalamus, J. Physiol. 349 (1984) 273-286.
42. R.M. Seaberg, D. van der Kooy, Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors, J. Neurosci. 22 (2002) 1784-1793.
43. T.J. Shors, G. Miesegaes, A. Beylin, M. Zhao, T. Rydel, E. Gould, Neurogenesis in the adult is involved in the formation of trace memories, Nature 410 (2001) 372-376.
44. P.J. Shughrue, I. Merchenthaler, Evidence for novel estrogen binding sites in the rat hippocampus, Neuroscience 99 (2000) 605-612.
45. P.J. Shughrue, C.D. Bushnell, D.M. Dorsa, Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males, Endocrinology 131 (1992) 381-388.
46. P.J. Shughrue, M.V. Lane, I. Merchenthaler, Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system, J. Comp. Neurol. 388 (1997) 507-525.
47. D.T. Solum, R.J. Handa, Localization of estrogen receptor α (ERα) in pyramidal neurons of the developing rat hippocampus, Dev. Brain Res. 128 (2001) 165-175.
48. L. Tanzer, D.R. Sengelaub, K.J. Jones, Estrogen receptor expression in the facial nucleus of adult hamsters: does axotomy recapitulate development? J. Neurobiol. 39 (1999) 438-446.
49. S. Tashiro, Y. Kondo, Y. Sakuma, Temporal coincidence between the excitation of ventromedial hypothalamic efferents and the induction of lordosis reflex in ovariectomized estrogen-primed rats, Endocr. J. 45 (1998) 519-528.
50. C.D. Toran-Allerand, M. Singh, G. Setalo Jr., Novel mechanisms of estrogen action in the brain: new players in an old story, Front. Neuroendocrinol. 20 (1999) 97-121.
51. L.A. Towart, S.E. Alves, V. Znamensky, S. Hayashi, B.S. McEwen, T.A. Milner, Subcellular relationships between cholinergic terminals and estrogen receptor-α in the dorsal hippocampus, J. Comp. Neurol. 463 (2003) 390-401.
52. Y. Wada-Kiyama, K. Kuwabara, Y. Sakuma, Y. Onishi, E.N. Trifonov, R. Kiyama, Localization of curved DNA and its association with nucleosome phasing in the promoter region of the human estrogen receptor a gene, FEBS Lett. 444 (1999) 117-124.
53. C.K. Wagner, J.L. Pfau, G.J. de Vries, I.J. Merchenthaler, Sex differences in progesterone receptor immunoreactivity in neonatal mouse brain depend on estrogen receptor α expression, J. Neurobiol. 47 (2001) 176-182.
54. C.S. Watson, A.M. Norfleet, T.C. Pappas, B. Gametchu, Rapid actions of estrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of estrogen receptor-α, Steroids 64 (1999) 5-13.
55. N.G. Weiland, C. Orikasa, S. Hayashi, B.S. McEwen, Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats, J. Comp. Neurol. 388 (1997) 603-612.
56. T. Wells, D.A. Carter, Genetic engineering of neural function in transgenic rodents: Towards a comprehensive strategy? J. Neurosci. Methods 108 (2001) 111-130.