Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

Oncotarget

Volumn 7, Issue 8, 2016, Pages 8771-8782

  Perdicchio, Maurizio ^a,d   Cornelissen, Lenneke A M ^a   Streng Ouwehand, Ingeborg ^a   Engels, Steef ^a   Verstege, Marleen I ^a   Boon, Louis ^b   Geerts, Dirk ^c   van Kooyk, Yvette ^a   Unger, Wendy W J ^a,e  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b EPIRUS Biopharmaceuticals   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d Fred Hutchinson Cancer Research Center   (United States)

^e SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Immune regulation; Natural killer cells; Regulatory T cells; Sialic acid; Tumor

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MEMBRANE ANTIGEN; SIALIC ACID; TRANSCRIPTION FACTOR FOXP3; MESSENGER RNA; N ACETYLNEURAMINIC ACID; POLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CANCER CONTROL; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; EVOKED RESPONSE; GENE EXPRESSION; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MELANOMA B16; MOUSE; NATURAL KILLER CELL; NEOPLASM; NONHUMAN; REGULATORY T LYMPHOCYTE; SAMBUCUS NIGRA; SIALYLATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR ESCAPE; TUMOR GROWTH; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR SIALYLATION; TUMOR VOLUME; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL ADHESION; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; ENZYME IMMUNOASSAY; EXPERIMENTAL MELANOMA; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; FLOW CYTOMETRY; IMMUNOENZYME TECHNIQUES; KILLER CELLS, NATURAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; N-ACETYLNEURAMINIC ACID; POLYSACCHARIDES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TUMOR CELLS, CULTURED; TUMOR MICROENVIRONMENT;

EID: 84960406089     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6822     Document Type: Article

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