Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity

Critical Care Medicine

Volumn 44, Issue 6, 2016, Pages 1034-1041

  Cohen, Jeremy ^a   Pretorius, Carel J ^a   Ungerer, Jacobus P J ^b   Cardinal, John ^a   Blumenthal, Antje ^a   Presneill, Jeff ^a   Gatica Andrades, Marcela ^a   Jarrett, Paul ^a   Lassig Smith, Melissa ^a   Stuart, Janine ^a   Dunlop, Rachel ^a   Starr, Therese ^a   Venkatesh, Bala ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QUEENSLAND HEALTH   (Australia)

Author keywords

adrenal insufficiency; cortisol; glucocorticoid resistance; septic shock

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR BETA; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; GLUCOCORTICOID RECEPTOR; TUMOR NECROSIS FACTOR;

ADRENAL FUNCTION; ADULT; APACHE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; IN VITRO STUDY; INTENSIVE CARE UNIT; LEUKOCYTE; MALE; MIDDLE AGED; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPTIC SHOCK; ADRENAL GLAND; AGED; BLOOD; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; METABOLISM; PATHOPHYSIOLOGY; SHOCK, SEPTIC;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ADRENAL GLANDS; ADULT; AGED; APACHE; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; DRUG RESISTANCE; FEMALE; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; INTERLEUKIN-10; INTERLEUKIN-6; LEUKOCYTES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SHOCK, SEPTIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84960405418     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001633     Document Type: Article

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