Steroids, oh steroids, my kingdom for some answers

Critical Care Medicine

Volumn 40, Issue 10, 2012, Pages 2897-2898

  Greenberg, Steven B ^a   Coursin, Douglas B ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

glucocorticoid receptor; glucocorticoid resistance; sepsis; steroids

Indexed keywords

CORTICOSTEROID; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HYDROCORTISONE; MICRORNA;

CONTINUOUS INFUSION; CORTICOSTEROID THERAPY; CRITICALLY ILL PATIENT; DRUG INTERMITTENT THERAPY; EDITORIAL; GENE EXPRESSION REGULATION; HORMONE RESISTANCE; HORMONE RESPONSIVE ELEMENT; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEPSIS; SEPTIC SHOCK; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

DRUG TOLERANCE; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; MICRORNAS; RECEPTORS, GLUCOCORTICOID; SEPSIS;

EID: 84866553690     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182632af6     Document Type: Editorial

References (17)

1. Coursin DB, Wood KE: Corticosteroid supplementation for adrenal insuffciency. JAMA 2002; 287:236-240
2. Bernard GR, Luce JM, Sprung CL, et al: High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med 1987; 317:1565-1570 (Pubitemid 18014383)
3. Bone RC, Fisher CJ Jr, Clemmer TP, et al: A controlled clinical trial of high-dose meth-ylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987; 317:653-658 (Pubitemid 17138189)
4. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis: The Veterans Administration Systemic Sepsis Cooperative Study Group. N Engl J Med 1987; 317: 659
5. Briegel J, Forst H, Haller M, et al: Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study. Crit Care Med 1999; 27:723-732 (Pubitemid 29218204)
6. Annane D, Sébille V, Charpentier C, et al: Effect of treatment with low doses of hydro-cortisone and fudrocortisone on mortality in patients with septic shock. JAMA 2002; 288:862-871
7. Sprung CL, Annane D, Keh D, et al; CORTI-CUS Study Group: Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358:111-124
8. Marik PE, Pastores SM, Annane D, et al; American College of Critical Care Medicine: Recommendations for the diagnosis and management of corticosteroid insuffciency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008; 36:1937-1949
9. Venkatesh B, Cohen J: Adrenocortical (dys) function in septic shock\A sick euadrenal state. Best Pract Res Clin Endocrinol Metab 2011; 25:719-733
10. Barnes PJ: Mechanisms and resistance in glu-cocorticoid control of infammation. J Steroid Biochem Mol Biol 2010; 120:76-85
11. Marik PE: Mechanisms and clinical consequences of critical illness associated adrenal insuffciency. Curr Opin Crit Care 2007; 13:363-369 (Pubitemid 47015771)
12. Niu N, Manickam V, Kalari KR, et al: Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: Gene resequencing and functional genomics. J Clin Endocrinol Metab 2009; 94:3072-3084
13. Vottero A, Chrousos GP: Glucocorticoid Receptor beta: View I. Trends Endocrinol Metab 1999; 10:333-338
14. Encío IJ, Detera-Wadleigh SD: The genomic structure of the human glucocorticoid receptor. J Biol Chem 1991; 266:7182-7188 (Pubitemid 21906349)
15. Ledderose C, Möhnle P, Limbeck E, et al: Cor-ticosteroid resistance in sepsis is infuenced by microRNA-124-induced downregulation of glucocorticoid receptor-α. Crit Care Med 2012; 40:2745-2753
16. DeAngelis JT, Farrington WJ, Tollefsbol TO: An overview of epigenetic assays. Mol Bio-technol 2008; 38:179-183
17. Matthews JG, Ito K, Barnes PJ, et al: Defective glucocorticoid receptor nuclear transloca-tion and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004; 113:1100-1108 (Pubitemid 38857992)