메뉴 건너뛰기




Volumn 71, Issue 1, 2009, Pages 145-153

Tissue mRNA expression of the glucocorticoid receptor and its splice variants in fatal critical illness

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; GLUCOCORTICOID RECEPTOR DELTA; HYDROCORTISONE; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 66949170606     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03443.x     Document Type: Article
Times cited : (27)

References (57)
  • 1
    • 0027168792 scopus 로고
    • The hypothalamic-pituitary-adrenal axis in critical illness: Response to dexamethasone and corticotropin-releasing hormone
    • Reincke, M., Allolio, B., Wurth, G. et al. (1993) The hypothalamic-pituitary-adrenal axis in critical illness: response to dexamethasone and corticotropin-releasing hormone. Journal of Clinical Endocrinology and Metabolism, 77, 151 156.
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.77 , pp. 151-156
    • Reincke, M.1    Allolio, B.2    Wurth, G.3
  • 2
    • 0021875976 scopus 로고
    • Variable adrenocortical function in acute medical illness
    • Drucker, D. Shandling, M. (1985) Variable adrenocortical function in acute medical illness. Critical Care Medicine, 13, 477 479. (Pubitemid 15063833)
    • (1985) Critical Care Medicine , vol.13 , Issue.6 , pp. 477-479
    • Drucker, D.1    Shandling, M.2
  • 3
    • 0022467065 scopus 로고
    • Adrenocortical dysfunction in acute medical illness
    • Drucker, D. McLaughlin, J. (1986) Adrenocortical dysfunction in acute medical illness. Critical Care Medicine, 14, 789 791. (Pubitemid 16003105)
    • (1986) Critical Care Medicine , vol.14 , Issue.9 , pp. 789-791
    • Drucker, D.1    McLaughlin, J.2
  • 4
    • 0023263030 scopus 로고
    • Spectrum of serum cortisol response to ACTH in ICU patients. Correlation with degree of illness and mortality
    • Jurney, T.H., Cockrell, J.L. Jr., Lindberg, J.S. et al. (1987) Spectrum of serum cortisol response to ACTH in ICU patients. Correlation with degree of illness and mortality. Chest, 92, 292 295. (Pubitemid 17125833)
    • (1987) Chest , vol.92 , Issue.2 , pp. 292-295
    • Jurney, T.H.1    Cockrell Jr., J.L.2    Lindberg, J.S.3
  • 6
    • 0029037126 scopus 로고
    • The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
    • Chrousos, G.P. (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. New England Journal of Medicine, 332, 1351 1362.
    • (1995) New England Journal of Medicine , vol.332 , pp. 1351-1362
    • Chrousos, G.P.1
  • 7
    • 0020627306 scopus 로고
    • Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin
    • Rivier, C. Vale, W. (1983) Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature, 305, 325 327.
    • (1983) Nature , vol.305 , pp. 325-327
    • Rivier, C.1    Vale, W.2
  • 8
    • 0033939971 scopus 로고    scopus 로고
    • Novel insights into the neuroendocrinology of critical illness
    • Van den Berghe, G. (2000) Novel insights into the neuroendocrinology of critical illness. European Journal of Endocrinology, 143, 1 13. (Pubitemid 30482194)
    • (2000) European Journal of Endocrinology , vol.143 , Issue.1 , pp. 1-13
    • Van Den Berghe, G.1
  • 9
    • 0033330663 scopus 로고    scopus 로고
    • Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: Neural and immune inputs
    • Bornstein, S.R. Chrousos, G.P. (1999) Clinical review 104. Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: neural and immune inputs. Journal of Clinical Endocrinology and Metabolism, 84, 1729 1736. (Pubitemid 30644284)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , Issue.5 , pp. 1729-1736
    • Bornstein, S.R.1    Chrousos, G.P.2
  • 10
    • 0028966732 scopus 로고
    • Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: Possible role of endothelin and atrial natriuretic hormone
    • Vermes, I., Beishuizen, A., Hampsink, R.M. et al. (1995) Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone. Journal of Clinical Endocrinology and Metabolism, 80, 1238 1242.
    • (1995) Journal of Clinical Endocrinology and Metabolism , vol.80 , pp. 1238-1242
    • Vermes, I.1    Beishuizen, A.2    Hampsink, R.M.3
  • 11
    • 0036431611 scopus 로고    scopus 로고
    • Dynamic neuroendocrine responses to critical illness
    • DOI 10.1016/S0091-3022(02)00006-7, PII S0091302202000067
    • Van den Berghe, G. (2002) Dynamic neuroendocrine responses to critical illness. Frontiers in Neuroendocrinology, 23, 370 391. (Pubitemid 35346212)
    • (2002) Frontiers in Neuroendocrinology , vol.23 , Issue.4 , pp. 370-391
    • Van Den Berghe, G.1
  • 14
    • 0026754132 scopus 로고
    • Adrenocortical function: An indicator of severity of disease and survival in chronic critically ill patients
    • Span, L.F., Hermus, A.R., Bartelink, A.K. et al. (1992) Adrenocortical function: an indicator of severity of disease and survival in chronic critically ill patients. Intensive Care Medicine, 18, 93 96.
    • (1992) Intensive Care Medicine , vol.18 , pp. 93-96
    • Span, L.F.1    Hermus, A.R.2    Bartelink, A.K.3
  • 18
    • 3042858950 scopus 로고    scopus 로고
    • Meta-analysis: The effect of steroids on survival and shock during sepsis depends on the dose
    • Minneci, P.C., Deans, K.J., Banks, S.M. et al. (2004) Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Annals of Internal Medicine, 141, 47 56.
    • (2004) Annals of Internal Medicine , vol.141 , pp. 47-56
    • Minneci, P.C.1    Deans, K.J.2    Banks, S.M.3
  • 19
    • 0036345304 scopus 로고    scopus 로고
    • Glucocorticoid receptor variants: Clinical implications
    • DOI 10.1016/S0960-0760(02)00062-6, PII S0960076002000626
    • DeRijk, R.H., Schaaf, M. de Kloet, E.R. (2002) Glucocorticoid receptor variants: clinical implications. Journal of Steroid Biochemistry and Molecular Biology, 81, 103 122. (Pubitemid 34879139)
    • (2002) Journal of Steroid Biochemistry and Molecular Biology , vol.81 , Issue.2 , pp. 103-122
    • DeRijk, R.H.1    Schaaf, M.2    De Kloet, E.R.3
  • 20
    • 0033600936 scopus 로고    scopus 로고
    • The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action
    • Oakley, R.H., Jewell, C.M., Yudt, M.R. et al. (1999) The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. Journal of Biological Chemistry, 274, 27857 27866.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 27857-27866
    • Oakley, R.H.1    Jewell, C.M.2    Yudt, M.R.3
  • 21
    • 0029056558 scopus 로고
    • Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
    • Bamberger, C.M., Bamberger, A.M., de Castro, M. et al. (1995) Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. Journal of Clinical Investigation, 95, 2435 2441.
    • (1995) Journal of Clinical Investigation , vol.95 , pp. 2435-2441
    • Bamberger, C.M.1    Bamberger, A.M.2    De Castro, M.3
  • 22
    • 27744432217 scopus 로고    scopus 로고
    • Expression of the human glucocorticoid receptor splice variants α, β, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism
    • DOI 10.1210/jc.2005-1042
    • Hagendorf, A., Koper, J.W., de Jong, F.H. et al. (2005) Expression of the human glucocorticoid receptor splice variants alpha, beta, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism. Journal of Clinical Endocrinology and Metabolism, 90, 6237 6243. (Pubitemid 41606550)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.11 , pp. 6237-6243
    • Hagendorf, A.1    Koper, J.W.2    De Jong, F.H.3    Brinkmann, A.O.4    Lamberts, S.W.J.5    Feelders, R.A.6
  • 26
    • 0020959670 scopus 로고
    • Therapeutic intervention scoring system: Update 1983
    • Keene, A.R. Cullen, D.J. (1983) Therapeutic intervention scoring system: update 1983. Critical Care Medicine, 11, 1 3.
    • (1983) Critical Care Medicine , vol.11 , pp. 1-3
    • Keene, A.R.1    Cullen, D.J.2
  • 27
    • 0029898011 scopus 로고    scopus 로고
    • Simplified therapeutic intervention scoring system: The TISS-28 items - Results from a multicenter study
    • Miranda, D.R., de Rijk, A. Schaufeli, W. (1996) Simplified therapeutic intervention scoring system: the TISS-28 items - results from a multicenter study. Critical Care Medicine, 24, 64 73.
    • (1996) Critical Care Medicine , vol.24 , pp. 64-73
    • Miranda, D.R.1    De Rijk, A.2    Schaufeli, W.3
  • 29
    • 0023105820 scopus 로고
    • Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin
    • DOI 10.1016/0022-4731(87)90071-9
    • Coolens, J.L., Van Baelen, H. Heyns, W. (1987) Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. Journal of Steroid Biochemistry, 26, 197 202. (Pubitemid 17040122)
    • (1987) Journal of Steroid Biochemistry , vol.26 , Issue.2 , pp. 197-202
    • Coolens, J.-L.1    Van Baelen, H.2    Heyns, W.3
  • 30
    • 0030008176 scopus 로고    scopus 로고
    • High primer concentration improves PCR amplification from random pools
    • DOI 10.1093/nar/24.5.985
    • Czerny, T. (1996) High primer concentration improves PCR amplification from random pools. Nucleic Acids Research, 24, 985 986. (Pubitemid 26076210)
    • (1996) Nucleic Acids Research , vol.24 , Issue.5 , pp. 985-986
    • Czerny, T.1
  • 31
    • 0036783767 scopus 로고    scopus 로고
    • Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues
    • Pujols, L., Mullol, J., Roca-Ferrer, J. et al. (2002) Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues. American Journal of Physiology. Cell Physiology, 283, C1324 C1331.
    • (2002) American Journal of Physiology. Cell Physiology , vol.283
    • Pujols, L.1    Mullol, J.2    Roca-Ferrer, J.3
  • 33
    • 0030691015 scopus 로고    scopus 로고
    • Evidence that the β-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor
    • DOI 10.1074/jbc.272.42.26659
    • Hecht, K., Carlstedt-Duke, J., Stierna, P. et al. (1997) Evidence that the beta-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor. Journal of Biological Chemistry, 272, 26659 26664. (Pubitemid 27458890)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.42 , pp. 26659-26664
    • Hecht, K.1    Carlstedt-Duke, J.2    Stierna, P.3    Gustafsson, J.-A.4    Bronnegard, M.5    Wikstrom, A.-C.6
  • 34
    • 0029993518 scopus 로고    scopus 로고
    • The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function
    • Oakley, R.H., Sar, M. Cidlowski, J.A. (1996) The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. Journal of Biological Chemistry, 271, 9550 9559.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 9550-9559
    • Oakley, R.H.1    Sar, M.2    Cidlowski, J.A.3
  • 36
    • 0033753883 scopus 로고    scopus 로고
    • Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia
    • Longui, C.A., Vottero, A., Adamson, P.C. et al. (2000) Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia. Hormone and Metabolic Research, 32, 401 406.
    • (2000) Hormone and Metabolic Research , vol.32 , pp. 401-406
    • Longui, C.A.1    Vottero, A.2    Adamson, P.C.3
  • 37
    • 0035809314 scopus 로고    scopus 로고
    • High constitutive glucocorticoid receptor β in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids
    • DOI 10.1084/jem.193.5.585
    • Strickland, I., Kisich, K., Hauk, P.J. et al. (2001) High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. Journal of Experimental Medicine, 193, 585 593. (Pubitemid 32539555)
    • (2001) Journal of Experimental Medicine , vol.193 , Issue.5 , pp. 585-593
    • Strickland, I.1    Kisich, K.2    Hauk, P.J.3    Vottero, A.4    Chrousos, G.P.5    Klemm, D.J.6    Leung, D.Y.M.7
  • 38
    • 0029807036 scopus 로고    scopus 로고
    • The non-ligand binding β-isoform of the human glucocorticoid receptor (hGRβ): Tissue levels, mechanism of action, and potential physiologic role
    • de Castro, M., Elliot, S., Kino, T. et al. (1996) The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role. Molecular Medicine, 2, 597 607. (Pubitemid 26353108)
    • (1996) Molecular Medicine , vol.2 , Issue.5 , pp. 597-607
    • De Castro, M.1    Elliot, S.2    Kino, T.3    Bamberger, C.4    Karl, M.5    Webster, E.6    Chrousos, G.P.7
  • 39
    • 0035810930 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance
    • DOI 10.1073/pnas.121455098
    • Webster, J.C., Oakley, R.H., Jewell, C.M. et al. (2001) Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proceedings of the National Academy of Sciences of the United States of America, 98, 6865 6870. (Pubitemid 32538308)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.12 , pp. 6865-6870
    • Webster, J.C.1    Oakley, R.H.2    Jewell, C.M.3    Cidlowski, J.A.4
  • 40
    • 0037372002 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid receptor mobility in living cells: The importance of ligand affinity
    • DOI 10.1128/MCB.23.6.1922-1934.2003
    • Schaaf, M.J. Cidlowski, J.A. (2003) Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity. Molecular and Cellular Biology, 23, 1922 1934. (Pubitemid 36278806)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.6 , pp. 1922-1934
    • Schaaf, M.J.M.1    Cidlowski, J.A.2
  • 41
    • 0035000828 scopus 로고    scopus 로고
    • Regulation of glucocorticoid receptor α and β isoforms and type I 11β-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: A key role in the pathogenesis of insulin resistance?
    • DOI 10.1210/jc.86.5.2296
    • Whorwood, C.B., Donovan, S.J., Wood, P.J. et al. (2001) Regulation of glucocorticoid receptor alpha and beta isoforms and type I, 11beta- hydroxysteroid dehydrogenase expression in human skeletal muscle cells: a key role in the pathogenesis of insulin resistance? Journal of Clinical Endocrinology and Metabolism, 86, 2296 2308. (Pubitemid 32472955)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.5 , pp. 2296-2308
    • Whorwood, C.B.1    Donovan, S.J.2    Wood, P.J.3    Phillips, D.I.W.4
  • 42
    • 0030774245 scopus 로고    scopus 로고
    • Expression and subcellular distribution of the β-isoform of the human glucocorticoid receptor
    • DOI 10.1210/en.138.11.5028
    • Oakley, R.H., Webster, J.C., Sar, M. et al. (1997) Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor. Endocrinology, 138, 5028 5038. (Pubitemid 27460944)
    • (1997) Endocrinology , vol.138 , Issue.11 , pp. 5028-5038
    • Oakley, R.H.1    Webster, J.C.2    Sar, M.3    Parker Jr., C.R.4    Cidlowski, J.A.5
  • 44
    • 0037456430 scopus 로고    scopus 로고
    • Corticosteroid insufficiency in acutely ill patients
    • DOI 10.1056/NEJMra020529
    • Cooper, M.S. Stewart, P.M. (2003) Corticosteroid insufficiency in acutely ill patients. New England Journal of Medicine, 348, 727 734. (Pubitemid 36237043)
    • (2003) New England Journal of Medicine , vol.348 , Issue.8 , pp. 727-734
    • Cooper, M.S.1    Stewart, P.M.2
  • 45
    • 0034762936 scopus 로고    scopus 로고
    • A review of the adrenal cortex and severe inflammation: Quest of the 'eucorticoid' state
    • Burchard, K. (2001) A review of the adrenal cortex and severe inflammation: quest of the 'eucorticoid' state. Journal of Trauma, 51, 800 814. (Pubitemid 33029310)
    • (2001) Journal of Trauma - Injury, Infection and Critical Care , vol.51 , Issue.4 , pp. 800-814
    • Burchard, K.1
  • 46
    • 0028843168 scopus 로고
    • Prediction of outcome in intensive care patients using endocrine parameters
    • Rothwell, P.M. Lawler, P.G. (1995) Prediction of outcome in intensive care patients using endocrine parameters. Critical Care Medicine, 23, 78 83.
    • (1995) Critical Care Medicine , vol.23 , pp. 78-83
    • Rothwell, P.M.1    Lawler, P.G.2
  • 47
    • 11444258512 scopus 로고    scopus 로고
    • Salivary cortisol concentration in the intensive care population: Correlation with plasma cortisol values
    • Cohen, J., Venkatesh, B., Galligan, J. et al. (2004) Salivary cortisol concentration in the intensive care population: correlation with plasma cortisol values. Anaesthesia and Intensive Care, 32, 843 845.
    • (2004) Anaesthesia and Intensive Care , vol.32 , pp. 843-845
    • Cohen, J.1    Venkatesh, B.2    Galligan, J.3
  • 48
    • 1842530882 scopus 로고    scopus 로고
    • Clinical review: Corticotherapy in sepsis
    • DOI 10.1186/cc2374
    • Prigent, H., Maxime, V. Annane, D. (2004) Clinical review: corticotherapy in sepsis. Critical Care Medicine, 8, 122 129. (Pubitemid 38436420)
    • (2004) Critical Care , vol.8 , Issue.2 , pp. 122-129
    • Prigent, H.1    Maxime, V.2    Annane, D.3
  • 49
    • 0023239471 scopus 로고
    • Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis
    • The Veterans Administration Systemic Sepsis Cooperative Study Group
    • The Veterans Administration Systemic Sepsis Cooperative Study Group (1987) Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. New England Journal of Medicine, 317, 659 665.
    • (1987) New England Journal of Medicine , vol.317 , pp. 659-665
  • 50
    • 0029090390 scopus 로고
    • Corticosteroid treatment for sepsis: A critical appraisal and meta-analysis of the literature
    • Cronin, L., Cook, D.J., Carlet, J. et al. (1995) Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Critical Care Medicine, 23, 1430 1439.
    • (1995) Critical Care Medicine , vol.23 , pp. 1430-1439
    • Cronin, L.1    Cook, D.J.2    Carlet, J.3
  • 53
    • 38049110809 scopus 로고    scopus 로고
    • Hydrocortisone therapy for patients with septic shock
    • Sprung, C.L., Annane, D., Keh, D. et al. (2008) Hydrocortisone therapy for patients with septic shock. New England Journal of Medicine, 358, 111 124.
    • (2008) New England Journal of Medicine , vol.358 , pp. 111-124
    • Sprung, C.L.1    Annane, D.2    Keh, D.3
  • 54
    • 0027942433 scopus 로고
    • Coordinate regulation of glucocorticoid receptor and c-jun mRNA levels: Evidence for cross-talk between two signaling pathways at the transcriptional level
    • DOI 10.1210/me.8.10.1336
    • Vig, E., Barrett, T.J. Vedeckis, W.V. (1994) Coordinate regulation of glucocorticoid receptor and C-jun mRNA levels: evidence for cross-talk between two signaling pathways at the transcriptional level. Molecular Endocrinology, 8, 1336 1346. (Pubitemid 24335077)
    • (1994) Molecular Endocrinology , vol.8 , Issue.10 , pp. 1336-1346
    • Vig, E.1    Barrett, T.J.2    Vedeckis, W.V.3
  • 55
    • 0028607388 scopus 로고
    • Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA down-regulation through multiple mechanisms
    • Burnstein, K.L., Jewell, C.M., Sar, M. et al. (1994) Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA down-regulation through multiple mechanisms. Molecular Endocrinology, 8, 1764 1773.
    • (1994) Molecular Endocrinology , vol.8 , pp. 1764-1773
    • Burnstein, K.L.1    Jewell, C.M.2    Sar, M.3
  • 56
    • 0032984227 scopus 로고    scopus 로고
    • In vivo modulation of glucocorticoid receptor mRNA by inhaled fluticasone propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma
    • DOI 10.1016/S0091-6749(99)70230-7
    • Andersson, O., Cassel, T.N., Gronneberg, R. et al. (1999) In vivo modulation of glucocorticoid receptor mRNA by inhaled fluticasone propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma. Journal of Allergy and Clinical Immunology, 103, 595 600. (Pubitemid 29295564)
    • (1999) Journal of Allergy and Clinical Immunology , vol.103 , Issue.4 , pp. 595-600
    • Andersson, O.1    Cassel, T.N.2    Gronneberg, R.3    Bronnegard, M.4    Stierna, P.5    Nord, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.