Elevated plasma-free cortisol concentrations and ratios are associated with increased mortality even in the presence of statin therapy in patients with severe sepsis

Critical Care Medicine

Volumn 43, Issue 3, 2015, Pages 630-635

  Venkatesh, Balasubramanian ^a   Imeson, Lee ^b   Kruger, Peter ^a   Cohen, Jeremy ^a   Jones, Mark ^a   Bellomo, Rinaldo ^c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

^c Australian and New Zealand Intensive Care Research Centre   (Australia)

Author keywords

Free cortisol; Inflammation; Interleukin 6; Sepsis; Statins; Total cortisol

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; HYDROCORTISONE; INTERLEUKIN 6; PLASMA FREE CORTISOL; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GOLD STANDARD; HUMAN; HYDROCORTISONE BLOOD LEVEL; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MORTALITY; OUTCOME ASSESSMENT; PLASMA TOTAL CORTISOL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SURVIVOR; AGED; APACHE; BLOOD; CLINICAL TRIAL; CRITICAL ILLNESS; MIDDLE AGED; MULTICENTER STUDY;

AGED; APACHE; CRITICAL ILLNESS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROCORTISONE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-6; LENGTH OF STAY; MALE; MASS SPECTROMETRY; MIDDLE AGED; SEPSIS;

EID: 84924286329     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000750     Document Type: Article

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