Rapid atrial pacing induces myocardial fibrosis by down-regulating Smad7 via microRNA-21 in rabbit

Heart and Vessels

Volumn 31, Issue 10, 2016, Pages 1696-1708

  He, Xuyu ^a   Zhang, Kunyi ^b,c   Gao, Xiuren ^c   Li, Liwen ^a   Tan, Hong ^a   Chen, Jiyan ^a   Zhou, Yingling ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Atrial fibrillation; Atrial fibrosis; MicroRNA 21; Smad7; Transforming growth factor 1

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; MICRORNA 21; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; COLLAGEN; MICRORNA; MIRN21 MICRORNA, RAT; SMAD7 PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIAL FIBRILLATION; CONTROLLED STUDY; DOWN REGULATION; FEEDBACK SYSTEM; GENE EXPRESSION; HEART ATRIUM PACING; HEART FIBROBLAST; HEART MUSCLE FIBROSIS; MALE; NEW ZEALAND RABBIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CARDIAC MUSCLE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; FIBROBLAST; FIBROSIS; GENETICS; METABOLISM; RABBIT; SPRAGUE DAWLEY RAT;

ANIMALS; ATRIAL FIBRILLATION; COLLAGEN; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FIBROBLASTS; FIBROSIS; MALE; MICRORNAS; MYOCARDIUM; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84960402447     PISSN: 09108327     EISSN: 16152573     Source Type: Journal    
DOI: 10.1007/s00380-016-0808-z     Document Type: Article

References (46)

1. Burstein B, Nattel S (2008) Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 51:802–809
2. Matsuda H, Parwani AS, Attanasio P, Huemer M, Wutzler A, Blaschke F, Haverkamp W, Boldt LH (2015) Atrial rhythm influences catheter tissue contact during radiofrequency catheter ablation of atrial fibrillation: comparison of contact force between sinus rhythm and atrial fibrillation. Heart Vessels. doi:10.1007/s00380-015-0763-0
3. Tan AY, Zimetbaum P (2011) Atrial fibrillation and atrial fibrosis. J Cardiovasc Pharmacol 57:625–629
4. Hoshiyama T, Yamabe H, Koyama J, Kanazawa H, Ogawa H (2015) Left atrial electrophysiologic feature specific for the genesis of complex fractionated atrial electrogram during atrial fibrillation. Heart Vessels. doi:10.1007/s00380-015-0672-2
5. Aldhoon B, Melenovsky V, Peichl P, Kautzner J (2010) New insights into mechanisms of atrial fibrillation. Physiol Res 59:1–12
6. Csepe TA, Kalyanasundaram A, Hansen BJ, Zhao J, Fedorov VV (2015) Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction. Front Physiol 6:37
7. de Oliveira IM, Oliveira BD, Scanavacca MI, Gutierrez PS (2013) Fibrosis, myocardial crossings, disconnections, abrupt turns, and epicardial reflections: do they play an actual role in human permanent atrial fibrillation? A controlled necropsy study. Cardiovasc Pathol 22:65–69
8. Gramley F, Lorenzen J, Koellensperger E, Kettering K, Weiss C, Munzel T (2010) Atrial fibrosis and atrial fibrillation: the role of the TGF-beta1 signaling pathway. Int J Cardiol 143:405–413
9. Gao X, He X, Luo B, Peng L, Lin J, Zuo Z (2009) Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. Eur J Pharmacol 606:115–120
10. He X, Gao X, Peng L, Wang S, Zhu Y, Ma H, Lin J, Duan DD (2011) Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7. Circ Res 108:164–175
11. Yan X, Liu Z, Chen Y (2009) Regulation of TGF-beta signaling by Smad7. Acta Biochim Biophys Sin (Shanghai) 41:263–272
12. Meng XM, Tang PM, Li J, Lan HY (2015) TGF-beta/Smad signaling in renal fibrosis. Front Physiol 6:82
13. Jazbutyte V, Thum T (2010) MicroRNA-21: from cancer to cardiovascular disease. Curr Drug Targets 11:926–935
14. Yang Y, Yang JJ, Tao H, Jin WS (2015) MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation. J Physiol Biochem 71:59–68
15. Dong S, Ma W, Hao B, Hu F, Yan L, Yan X, Wang Y, Chen Z, Wang Z (2014) MicroRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2. Int J Clin Exp Pathol 7:565–574
16. Bhagat TD, Zhou L, Sokol L, Kessel R, Caceres G, Gundabolu K, Tamari R, Gordon S, Mantzaris I, Jodlowski T, Yu Y, Jing X, Polineni R, Bhatia K, Pellagatti A, Boultwood J, Kambhampati S, Steidl U, Stein C, Ju W, Liu G, Kenny P, List A, Bitzer M, Verma A (2013) MiR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling. Blood 121:2875–2881
17. Chung AC, Dong Y, Yang W, Zhong X, Li R, Lan HY (2013) Smad7 suppresses renal fibrosis via altering expression of TGF-beta/Smad3-regulated microRNAs. Mol Ther 21:388–398
18. Duygu B, Da CMP (2015) miR-21: a star player in cardiac hypertrophy. Cardiovasc Res 105:235–237
19. Lan HY, Chung AC (2011) Transforming growth factor-beta and Smads. Contrib Nephrol 170:75–82
20. Bonci D (2010) MicroRNA-21 as therapeutic target in cancer and cardiovascular disease. Recent Pat Cardiovasc Drug Discov 5:156–161
21. Buscaglia LE, Li Y (2011) Apoptosis and the target genes of microRNA-21. Chin J Cancer 30:371–380
22. Liang H, Zhang C, Ban T, Liu Y, Mei L, Piao X, Zhao D, Lu Y, Chu W, Yang B (2012) A novel reciprocal loop between microRNA-21 and TGFbetaRIII is involved in cardiac fibrosis. Int J Biochem Cell Biol 44:2152–2160
23. Orenes-Pinero E, Montoro-Garcia S, Patel JV, Valdes M, Marin F, Lip GY (2013) Role of microRNAs in cardiac remodelling: new insights and future perspectives. Int J Cardiol 167:1651–1659
24. Garcia R, Nistal JF, Merino D, Price NL, Fernandez-Hernando C, Beaumont J, Gonzalez A, Hurle MA, Villar AV (2015) p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling. Biochim Biophys Acta 1852:1520–1530
25. Wang JY, Gao YB, Zhang N, Zou DW, Wang P, Zhu ZY, Li JY, Zhou SN, Wang SC, Wang YY, Yang JK (2014) miR-21 overexpression enhances TGF-beta1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol Cell Endocrinol 392:163–172
26. Moriguchi M, Niwano S, Yoshizawa N, Kitano Y, Kojima J, Inuo K, Saitou J, Izumi T (2001) Inhomogeneity in the appearance of electrical remodeling during chronic rapid atrial pacing: evaluation of the dispersion of atrial effective refractoriness. Jpn Circ J 65:335–340
27. Sheeha C, Hrapchak B (1980) Theory and practice of histotechnology. Battelle Press, Columbus, pp 24–36
28. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(−∆∆ C(T)) Method. Methods 25:402–408
29. Bumrungthai S, Ekalaksananan T, Evans MF, Chopjitt P, Tangsiriwatthana T, Patarapadungkit N, Kleebkaow P, Luanratanakorn S, Kongyingyoes B, Worawichawong S, Pientong C (2015) Up-regulation of miR-21 is associated with cervicitis and human papillomavirus infection in cervical tissues. PLoS ONE 10:e0127109
30. Rosato P, Anastasiadou E, Garg N, Lenze D, Boccellato F, Vincenti S, Severa M, Coccia EM, Bigi R, Cirone M, Ferretti E, Campese AF, Hummel M, Frati L, Presutti C, Faggioni A, Trivedi P (2012) Differential regulation of miR-21 and miR-146a by Epstein-Barr virus-encoded EBNA2. Leukemia 26:2343–2352
31. Sheng H (1995) Study on the quantitative methods of immunohistochemistry. Chin J Histochem Cytochem 4:89–92
32. Kumarswamy R, Volkmann I, Thum T (2011) Regulation and function of miRNA-21 in health and disease. RNA Biol 8:706–713
33. Li Q, Zhang D, Wang Y, Sun P, Hou X, Larner J, Xiong W, Mi J (2013) MiR-21/Smad 7 signaling determines TGF-beta1-induced CAF formation. Sci Rep 3:2038
34. Fukaya H, Niwano S, Satoh D, Masaki Y, Niwano H, Kojima J, Moriguchi M, Izumi T (2008) Inhomogenic effect of bepridil on atrial electrical remodeling in a canine rapid atrial stimulation model. Circ J 72:318–326
35. Anne W, Willems R, Holemans P, Beckers F, Roskams T, Lenaerts I, Ector H, Heidbuchel H (2007) Self-terminating AF depends on electrical remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model. J Mol Cell Cardiol 43:148–158
36. Cha TJ, Ehrlich JR, Zhang L, Shi YF, Tardif JC, Leung TK, Nattel S (2004) Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure. Circulation 109:412–418
37. Kalman JM, Kumar S, Sanders P (2012) Markers of collagen synthesis, atrial fibrosis, and the mechanisms underlying atrial fibrillation. J Am Coll Cardiol 60:1807–1808
38. Kim GH (2013) MicroRNA regulation of cardiac conduction and arrhythmias. Transl Res 161:381–392
39. Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY (2011) TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J Am Soc Nephrol 22:1462–1474
40. Velu VK, Ramesh R, Srinivasan AR (2012) Circulating microRNAs as biomarkers in health and disease. J Clin Diagn Res 6:1791–1795
41. Kato M, Arce L, Wang M, Putta S, Lanting L, Natarajan R (2011) A microRNA circuit mediates transforming growth factor-beta1 autoregulation in renal glomerular mesangial cells. Kidney Int 80:358–368
42. Cardin S, Guasch E, Luo X, Naud P, Le Quang K, Shi Y, Tardif JC, Comtois P, Nattel S (2012) Role for microRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure. Circ Arrhythm Electrophysiol 5:1027–1035
43. Adam O, Lohfelm B, Thum T, Gupta SK, Puhl SL, Schafers HJ, Bohm M, Laufs U (2012) Role of miR-21 in the pathogenesis of atrial fibrosis. Basic Res Cardiol 107:278
44. Wei LH, Huang XR, Zhang Y, Li YQ, Chen HY, Heuchel R, Yan BP, Yu CM, Lan HY (2013) Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension. PLoS ONE 8:e70195
45. Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, Thannickal VJ, Kaminski N, Abraham E (2010) miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 207:1589–1597
46. Zhong X, Chung AC, Chen HY, Dong Y, Meng XM, Li R, Yang W, Hou FF, Lan HY (2013) miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes. Diabetologia 56:663–674