Atrial fibrosis and atrial fibrillation: The role of the TGF-β1 signaling pathway

International Journal of Cardiology

Volumn 143, Issue 3, 2010, Pages 405-413

  Gramley, Felix ^a   Lorenzen, Johann ^b   Koellensperger, Eva ^c   Kettering, Klaus ^a   Weiss, Christian ^a   Munzel, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Dortmund Hospital   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Atrial; Fibrillation; Fibrosis; Remodeling; TGF

Indexed keywords

COLLAGEN; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; FEMALE; FIBROSIS; GENE EXPRESSION; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART ATRIUM FIBROSIS; HEART RHYTHM; HEART RIGHT ATRIUM; HEART SURGERY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE STUDY; SIGNAL TRANSDUCTION; SINUS RHYTHM;

AGED; ATRIAL APPENDAGE; ATRIAL FIBRILLATION; BIOPSY; CHRONIC DISEASE; FEMALE; FIBROSIS; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77956620327     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2009.03.110     Document Type: Article

References (45)

1. W.B. Kannel, P.A. Wolf, E.J. Benjamin, and D. Levy Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates Am J Cardiol 82 8A 1998 2N 9N (Pubitemid 28507114)
2. A. Goette, U. Lendeckel, and H.U. Klein Signal transduction systems and atrial fibrillation Cardiovasc Res 54 2 2002 247 258
3. D. Li, S. Fareh, T.K. Leung, and S. Nattel Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort Circulation 100 1 1999 87 95
4. R. Khan, and R. Sheppard Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia Immunology 118 1 2006 10 24
5. F. Gramley, J. Lorenzen, and J. Plisiene Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation J Cardiovasc Electrophysiol 18 10 2007 1076 1082
6. F. Gramley, J. Lorenzen, C. Knackstedt, O. Rana, E. Saygili, D. Frenchen, S. Stanzel, F. Pezzella, E. Koellensperger, C. Weiss, T. Münzel, and P. Schauerte Age-Related Atrial Fibrosis Age 31 1 2009 27 38
7. K. Shinagawa, Y.F. Shi, J.C. Tardif, T.K. Leung, and S. Nattel Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs Circulation 105 22 2002 2672 2678
8. H. Nakajima, H.O. Nakajima, and O. Salcher Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-beta(1) transgene in the heart Circ Res 86 5 2000 571 579
9. D.W. O'Brien, Y. Fu, and H.R. Parker Differential morphometric and ultrastructural remodelling in the left atrium and left ventricle in rapid ventricular pacing-induced heart failure Can J Cardiol 16 11 2000 1411 1419
10. B. Burstein, E. Libby, A. Calderone, and S. Nattel Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences Circulation 117 13 2008 1630 1641
11. P.J. Lijnen, V.V. Petrov, and R.H. Fagard Induction of cardiac fibrosis by transforming growth factor-beta(1) Mol Genet Metab 71 1-2 2000 418 435
12. J. Hao, H. Ju, S. Zhao, A. Junaid, T. Scammell-La Fleur, and I.M. Dixon Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing J Mol Cell Cardiol 31 3 1999 667 678
13. K. Miyazono, K. Kusanagi, and H. Inoue Divergence and convergence of TGF-beta/BMP signaling J Cell Physiol 187 3 2001 265 276
14. M. Lutz, and P. Knaus Integration of the TGF-beta pathway into the cellular signalling network Cell Signal 14 12 2002 977
15. C.H. Heldin, K. Miyazono, and P. ten Dijke TGF-beta signalling from cell membrane to nucleus through SMAD proteins Nature 390 6659 1997 465 471
16. A.J. Sanfilippo, V.M. Abascal, and M. Sheehan Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study Circulation 82 3 1990 792 797
17. I.S. Jamall, V.N. Finelli, and S.S. Que Hee A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues Anal Biochem 112 1 1981 70 75
18. R.E. Neuman, and M.A. Logan The determination of collagen and elastin in tissues J Biol Chem 186 2 1950 549 556
19. D.E. Oken, and R.J. Boucek Quantitation of collagen in human myocardium Circ Res 5 4 1957 357 361
20. R. Bender, and S. Lange Adjusting for multiple testing-when and how? J Clin Epidemiol 54 4 2001 343 349
21. M. Wijffels, C. Kirchhof, R. Dorland, and M. Allessie Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats Circulation 92 7 1995 1954 1968
22. R. Gaspo, R.F. Bosch, M. Talajic, and S. Nattel Functional mechanisms underlying tachycardia-induced sustained atrial fibrillation in a chronic dog model Circulation 96 11 1997 4027 4035
23. V.L. Thijssen, J. Ausma, and M. Borgers Structural remodelling during chronic atrial fibrillation: act of programmed cell survival Cardiovasc Res 52 1 2001 14 24
24. U. Schotten, H.R. Neuberger, and M.A. Allessie The role of atrial dilatation in the domestication of atrial fibrillation Prog Biophys Mol Biol 82 1-3 2003 151 162
25. R.S. Phang, S.M. Isserman, and D. Karia Echocardiographic evidence of left atrial abnormality in young patients with lone paroxysmal atrial fibrillation Am J Cardiol 94 4 2004 511 513
26. C. Rostagno, G. Olivo, M. Comeglio, G. Bertini, G.F. Gensini, and G. Galanti Left atrial size changes in patients with paroxysmal lone atrial fibrillation. An echocardiographic follow-up Angiology 47 8 1996 797 801
27. W. Anne, R. Willems, and T. Roskams Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation Cardiovasc Res 67 4 2005 655 666
28. A. Goette, M. Arndt, and C. Rocken Regulation of angiotensin II receptor subtypes during atrial fibrillation in humans Circulation 101 23 2000 2678 2681
29. M.B. Jibrini, J. Molnar, and R.R. Arora Prevention of atrial fibrillation by way of abrogation of the renin-angiotensin system: a systematic review and meta-analysis Am J Ther 15 1 2008 36 43
30. E. Vermes, J.C. Tardif, and M.G. Bourassa Enalapril decreases the incidence of atrial fibrillation in patients with left ventricular dysfunction: insight from the Studies Of Left Ventricular Dysfunction (SOLVD) trials Circulation 107 23 2003 2926 2931 (Pubitemid 36736634)
31. A. Boldt, A. Scholl, and J. Garbade ACE-inhibitor treatment attenuates atrial structural remodeling in patients with lone chronic atrial fibrillation Basic Res Cardiol 101 3 2006 261 267
32. Y. Seko, H. Nishimura, N. Takahashi, T. Ashida, and R. Nagai Serum levels of vascular endothelial growth factor and transforming growth factor-beta1 in patients with atrial fibrillation undergoing defibrillation therapy Jpn Heart J 41 1 2000 27 32
33. X. Li, C. Ma, and J. Dong The fibrosis and atrial fibrillation: is the transforming growth factor-beta(1) a candidate etiology of atrial fibrillation Med hypotheses 70 2 2008 317 319
34. Y. Inaba, S. Yuda, and N. Kobayashi Strain rate imaging for noninvasive functional quantification of the left atrium: comparative studies in controls and patients with atrial fibrillation J Am Soc Echocardiogr 18 7 2005 729 736
35. N. Kokubu, S. Yuda, and K. Tsuchihashi Noninvasive assessment of left atrial function by strain rate imaging in patients with hypertension: a possible beneficial effect of renin-angiotensin system inhibition on left atrial function Hypertens Res 30 1 2007 13 21
36. N.D. Epstein, and J.S. Davis Sensing stretch is fundamental Cell 112 2 2003 147 150
37. B. Burstein, and S. Nattel Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation J Am Coll Cardiol 51 8 2008 802 809
38. J. Li, T. Hampton, J.P. Morgan, and M. Simons Stretch-induced VEGF expression in the heart J Clin Invest 100 1 1997 18 24
39. F. Kuwahara, H. Kai, and K. Tokuda Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats Circulation 106 1 2002 130 135
40. V. Polyakova, S. Miyagawa, Z. Szalay, J. Risteli, and S. Kostin Atrial extracellular matrix remodelling in patients with atrial fibrillation J Cell Mol Med 12 1 2008 189 208
41. M. Landstrom, N.E. Heldin, and S. Bu Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells Curr Biol 10 9 2000 535 538
42. A. Nakao, M. Afrakhte, and A. Moren Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling Nature 389 6651 1997 631 635
43. C.E. Pierreux, F.J. Nicolas, and C.S. Hill Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus Mol Cell Biol 20 23 2000 9041 9054
44. W. Balemans, and W. Van Hul Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators Dev Biol 250 2 2002 231 250
45. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2009 149 150