MiR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy

Molecular and Cellular Endocrinology

Volumn 392, Issue 1-2, 2014, Pages 163-172

  Wang, Jin Yang ^a,b,c   Gao, Yan Bin ^a   Zhang, Na ^a   Zou, Da Wei ^a   Wang, Peng ^a   Zhu, Zhi Yao ^a   Li, Jiao Yang ^a   Zhou, Sheng Nan ^a   Wang, Shao Cheng ^b   Wang, Ying Ying ^b   Yang, Jin Kui ^b,c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c Beijing Key Laboratory of Diabetes Research and Care   (China)

Author keywords

Diabetic nephropathy; Epithelial to mesenchymal transition; MicroRNA(miR); Renal interstitial fibrosis; TGF 1

Indexed keywords

COLLAGEN FIBER; COLLAGEN TYPE 4; MICRORNA 21; SMAD3 PROTEIN; SMAD7 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; ACTA2 PROTEIN, HUMAN; ACTIN; BIOLOGICAL MARKER; CADHERIN; MICRORNA; MIRN21 MICRORNA, HUMAN; MIRN21 MICRORNA, MOUSE; SMAD7 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CREATININE CLEARANCE; DIABETIC NEPHROPATHY; DOWN REGULATION; DRUG TARGETING; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY STRUCTURE; LUCIFERASE ASSAY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL LINE; DRUG EFFECTS; GENETICS; KIDNEY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHOSPHORYLATION; ULTRASTRUCTURE;

ACTINS; ANIMALS; BASE SEQUENCE; BIOLOGICAL MARKERS; CADHERINS; CELL LINE; DIABETIC NEPHROPATHIES; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; KIDNEY; MALE; MICE, INBRED C57BL; MICRORNAS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84902528910     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.05.018     Document Type: Article

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